COX 억제제에 의해 유도되는 구강편평세포암종 세포주의 성장 억제 효과

박광진,한세진,이재훈,Park, Gwang-Jin,Han, Se-Jin,Lee, Jae-Hoon 대한악안면성형재건외과학회 2008 Maxillofacial Plastic Reconstructive Surgery Vol.30 No.4

The objectives of this study was to explore the growth pattern of the oral squamous cell carcinoma when overexpressed COX was inhibited, explore the pathway that COX inhibitors suppressed the proliferation of cancer cells, and then hereafter investigate the potential of COX as chemopreventive target for oral squamous cell carcinoma. For confirming the COX-dependent effect and mechanisms on growth of the oral cancer cells, we treated the nonselective NSAID, Mefenamic acid and COX-2 selective inhibitor, Celecoxib in HN4 cell line. And then the cell line was evaluated with MTT assay and growth curve, the production of PGE2, total RNA extraction and RT-PCR analysis, and TEM The results were obtained as follows: 1. After administration of medication, in the result of MTT assay, Celecoxib inoculated group inhibit the cell growth rather than Mefenamic acid inoculated group. 2. The growth curve of cell line showed as time passes by there was a dramatic cell growth in the control group, and gradual growth inhibition was found in medication inoculated group and, in Celecoxib inoculated group there was more inhibition of cell growth. 3. After the administration of medication, Celecoxib tend to inhibit the synthesis of PGE2 more than Mefenamic acid. Mefenamic acid inhibit the synthesis of PGE2 more as the concentration gets high, but Celecoxib inhibited the synthesis of PGE2 even in low concentration. 4. After the administration of medication, the revelation of COX mRNA in cell line, there was a 50% decrease in COX-1, 60% decrease in COX-2 as in $50{\mu}M$ Mefenamic acid, and in Celecoxib $50{\mu}M$ there was not much difference in COX-1 and 90% decrease in COX-2 was found. 5. HN4 cell line showed broken nucleus and tangled cytoskeleton bundles in cytoplasm which meant apoptotic features after the treatment of Celecoxib in TEM view. Depending on the above results, we estimate that the inhibition of the expression of COX-2 cause the growth suppression of the oral squamous cell carcinoma, and it get achieved through pathway of reduced PGE2 production and increased apoptosis. In addition to, because COX-2 selective inhibitor specifically act to COX-2, it is considered that COX-2 selective inhibitor has the adequate potential as chemopreventive agent for oral squamous cell carcinoma.

저소음 고효율 시로코 홴 개발에 관한 연구

박광진,이상환,손병진,Park, Kwang-Jin,Lee, Sang-Hwan,Son, Byung-Jin 한국유체기계학회 1999 한국유체기계학회 논문집 Vol.2 No.2

This study is on the performance prediction and design of a sirocco fan. Slip coefficient is very important factor for the performance analysis of a centrifugal-type fan. Because generally used slip coefficient equations of backward curved centrifugal fan are not appropriate for forward curved sirocco fan, in this study a proper slip coefficient equation for a sirocco fan is suggested. Using this equation performance prediction program for sirocco fan is composed of and also included the total noise prediction that include the turbulent noise at the fan inlet and boundary layer noise. A comparison between the values obtained from performance prediction program and experimental values shows that the program predicts the sirocco fan performance in a practical rate.

한우에 있어서 농후사료 급여 수준이 비육효과에 미치는 영향

박광진,지설하 ( Kwang Jin Park,Sul Ha Chee ) 한국축산학회 1977 한국축산학회지 Vol.19 No.5

This study was carried out to find out the optimum level of concentrates to be allowed for the fattening Korean native bulls. Twenty five bulls were used for this trials at Yesan, Chungnam province for 7 months from July. 1976 to February, 1977. Rughages were fed ad libitum and concentrates was allowed at the levels of 0, 0.5, 1.0, 1.5 and 2.0% on body weight. The results obtained from this study were as follows: 1. The final weight of fattened bulls were 303.4, 361.2, 398.5, 422.3 and 456.0㎏ by the different levels of concentrates as 0, 0.5, 1.0, 1.5 and 2.0% of body weight, respectively. The finished body weights were significantly different from the different level of concentrates (P$lt;0.01). 2. The amount of DCP required for 1㎏ of body gain were 0.94, 0.73, 0.80, 0.87 and 0.85㎏ with the concentrates levels of 0, 0.5, 1.0, 1.5 and 2.0%, respectively. The amount of TDN required for 1㎏ of body gain were 12.40, 7.15, 7.23, 8.27 and 7.20㎏, respectively, in order of concentrates levels to be allowed. There was a tendency that feeds efficiency was the highest at the 0.5% of concentrates level among the different levels of concentrates to be fed. 3. The chilled carcass percentages were 52.4, 54.7, 57.1, 59.2 and 60.2% respectively with the levels of concentrates to be fed as 0, 0.5 10, 1 1.5 and 2.0% on live weights. The chilled carcass percentages were increased by the high levels of concentrates to be allowed. This study was carried out to find out the optimum level of concentrates to be allowed for the fattening Korean native bulls. Twenty five bulls were used for this trials at Yesan, Chungnam province for 7 months from July. 1976 to February, 1977. Rughages were fed ad libitum and concentrates was allowed at the levels of 0, 0.5, 1.0, 1.5 and 2.0% on body weight. The results obtained from this study were as follows: 1. The final weight of fattened bulls were 303.4, 361.2, 398.5, 422.3 and 456.0㎏ by the different levels of concentrates as 0, 0.5, 1.0, 1.5 and 2.0% of body weight, respectively. The finished body weights were significantly different from the different level of concentrates (P$lt;0.01). 2. The amount of DCP required for 1㎏ of body gain were 0.94, 0.73, 0.80, 0.87 and 0.85㎏ with the concentrates levels of 0, 0.5, 1.0, 1.5 and 2.0%, respectively. The amount of TDN required for 1㎏ of body gain were 12.40, 7.15, 7.23, 8.27 and 7.20㎏, respectively, in order of concentrates levels to be allowed. There was a tendency that feeds efficiency was the highest at the 0.5% of concentrates level among the different levels of concentrates to be fed. 3. The chilled carcass percentages were 52.4, 54.7, 57.1, 59.2 and 60.2% respectively with the levels of concentrates to be fed as 0, 0.5 10, 1 1.5 and 2.0% on live weights. The chilled carcass percentages were increased by the high levels of concentrates to be allowed.

중.저온형 고체산화물 연료전지에서 연료로 공급되는 CO 와 H₂ 가 성능에 미치는 영향

박광진,배중면,Park, Kwang-Jin,Bae, Joong-Myeon 대한기계학회 2008 大韓機械學會論文集B Vol.32 No.12

The performance behavior of solid oxide fuel cell using $H_2$ and CO as fuels was investigated. The power densities and impedance results showed a little variation as the ratio of $H_2$ and CO changed. However, when the pure CO was used as a fuel, area specific resistance (ASR), especially low frequency region, was increased. This might be due to carbon deposition on anode. The maximum power density was 60% lower using CO than using $H_2$. Carbon deposition reduced after constant current was applied. The SOFC performance was recovered from the carbon deposition after applying constant current during 100h.

인터넷사이트의 개인정보보호 대책

박광진,Park, Gwang-Jin 한국정보통신집흥협회 2000 정보화사회 Vol.142 No.-

중저온형 SOFC를 위한 PSCF3737(Pr_0.3Sr_0.7Co_0.3Fe_0.7O₃) 공기극 물질의 특성 및 최적화께 관한 연구

박광진,이창보,김정현,백승욱,배중면,Park, Kwang-Jin,Lee, Chang-Bo,Kim, Jung-Hyun,Baek, Seung-Wook,Bae, Joong-Myeon 한국전기화학회 2007 한국전기화학회지 Vol.10 No.3

IT-SOFC(중저온형 고체산화물 연료전지)의 공기극으로 적합한 PSCF3737의 물질 특성을 파악하고 그 특성을 이용하여 낮은 ASR을 갖기 위한 소결 온도 및 두께 최적화에 관한 연구를 수행하였다. 분말 사이즈 및 상형성을 고려할 때 GNP 방법으로 합성된 분말의 하소 온도는 $1000^{\circ}C$가 적합함을 알 수 있었다. 산소 분압에 따른 ASR 변화 실험을 통하여 PSCF3737의 저항 성분을 전극 자체의 특성과 관련된 중간 주파수 대역(${\sim}10^2Hz$)과 산소의 확산에 영향 받는 낮은 주파수 대역(${\sim}10^{-1}Hz$) 2가지로 분류할 수 있었다. 공기극의 특성 실험을 통하여 소결 온도는 $1200^{\circ}C$가 가장 적합하며 공기극의 두께는 2번 스크린 프린팅 된 $27\;{\mu}m$가 가장 적합함을 알 수 있었다. 이를 토대로 EIS 측정을 하면 $700^{\circ}C$에서 $0.115\;{\Omega}cm^2$의 낮은 ASR값을 얻을 수 있었다. [ $PSCF3737(Pr_{0.3}Sr_{0.7}Co_{0.3}Fe_{0.7}O_3)$ ] is a good candidate cathode material for IT-SOFC(intermediate temperature solid oxide fuel cell) because of high MIEC(mixed ionic electronic conductor) conductivity. In this study, the characteristics of PSCF3737 was investigated and optimizations of sintering temperature and thickness for $PSCF3737(Pr_{0.3}Sr_{0.7}Co_{0.3}Fe_{0.7}O_3)$ was carried out. Impedance responses were divided into two parts by frequency region. Middle frequency part (${\sim}10^2\;Hz$) was concerned with oxygen reduction reaction on surface and low frequency part (${\sim}10^{-1}\;Hz$) was related with oxygen diffusion. The reasonable sintering temperature and thickness of cathode were $1200^{\circ}C$ and about $27\;{\mu}m$ with regard to EIS(electrochemical impedance spectroscopy). ASR(areas specific resistance) of optimized cathode is $0.115\;{\Omega}\;cm^2$ at $700^{\circ}C$.

중.저온형 고체 산화물 연료전지의 공기극 물질로 사용되는 Pr_0.3Sr_0.7Co_xMn_(1-x)O₃ (x=0, 0.3, 0.5, 0.7, 1)에 관한 연구

박광진,김정현,배중면,Park, Kwang-Jin,Kim, Jung-Hyun,Bae, Joong-Myeon 한국세라믹학회 2007 한국세라믹학회지 Vol.44 No.4

The decrease of polarization resistance in cathode is the key point for operating at intermediate temperature SOFC (solid oxide fuel cell). In this study, the influence of Co substitution in B-site at complex perovskite on the electronic conductivity of PSCM ($Pr_{0.3}Sr_{0.7}Co_xMn_{(1-x)}$) was investigated. The PSCM series exhibits excellent MIEC (mixed ionic electronic conductor) properties. The ASR (area specific resistance) of PSCM3773 was $0.174{\Omega}{\cdot}cm^2\;at\;700^{\circ}C$. The activation energy of PSCM3773 was also lower than other compositions of PSCM. The TEC(thermal expansion coefficient) was decreased by addition of Mn. The ASR values were increased gradually during the thermal cycling test of PSCM37773 due to the delamination between electrolyte and cathode materials. The delamination was caused by the difference of TEC.

중·저온형 고체 산화물 연료전지의 공기극 물질로 사용되는 Pr_0.3Sr_0.7CO_xFe_(1-x)O_3-δ (x=0, 0.3, 0.5, 0.7, 1) 에 관한 연구

박광진(Park, Kwang-Jin),김정현(Kim, Jung-Hyun),이창보(Lee, Chang-Bo),배중면(Bae, Joong-Myeon) 한국신재생에너지학회 2007 한국신재생에너지학회 학술대회논문집 Vol.2007 No.06

The influence of Co substitution in B-site at perovskite PSCF(Pr_0.3Sr_0.7CO_xFe_(1-x)O₃) was investigated in this study. The PSCF series exhibits excellent MIEC(mixed ionic electronic conductor) properties. ASR(area specific resistance) of PSCF3737 was 0.137 ω·cm² at 700?C. The activation energy of PSCF3737 was also lower than other compositions of PSCF. ASR of PSCF3737 was analysed as two parts at different part of frequency region. Responses at middle frequency part ({sim}10² Hz) were concerned with oxygen reduction reaction and those at low frequency part ({sim}10^-1 Hz) were related with oxygen diffusion.

승용차 내장용 에어 밴트 부품 사출 금형 개발에 관한 연구

박광진(Park, Kwang-Jin),임태양(Lim, Tae-Yang),박태현(Park, Tae-Hyun),김기선(Kim, Key-Sun),김송화(Kim, Song-Hwa) 한국산학기술학회 2010 한국산학기술학회 학술대회 Vol.- No.-

본 논문은 자동차의 부품 중 에어 밴트를 효율적으로 개발하기 위하여 제품의 형상, 사출 해석, 변형과 그 제품이 완성차에 설치 시 열유동에 관한 해석 및 개발에 관한 논문이다. 이를 위하여 3차원 설계를 한 후, 사출성형 공정에 대한 충전시간, 웰드 라인, 에어트랩 등 사출 성형 공정에 대한 분석 하였다. 다음으로 완성차에 조립된 상태에서 열유동 해석을 통하여 제품 윤곽선의 적합성을 확립하였으며 이를 바탕으로 하여 금형을 제작할 수 있는 설계조건을 확립 하였다.

프로 경륜선수의 직업 전환 인과모형 분석

박광진 ( Kwang Jin Park ),이강헌 ( Kang Hun Lee ) 한국스포츠심리학회 2011 한국스포츠심리학회지 Vol.22 No.2

본 연구는 프로 경륜선수를 대상으로 직업 전환에 영향을 미치는 요인들 간의 인과관계를 설명하는 구조모형을 개발하기 위해 프로 경륜선수 448명을 분석대상으로 하였다. 통계분석 방법으로는 기술통계분석, 신뢰도분석, 탐색적 요인분석, 확인적 요인분석, 상관관계 분석, 구조방정식 모형분석, 잠재평균분석, 다중집단분석 등을 SAS 9.1과 SPSS 18.0, AMOS 18.0을 사용하였으며, 분석한 결과는 다음과 같다. 첫째, 신뢰성과 타당성이 인정된 최종 4개의 측정모형을 바탕으로 설정한 구조모형의 적합도 지수들은 모두 기준치를 만족시켰으며, 인과효과를 분석한 결과, 진로자기효능감에는 자아정체성(γ = .730)의 영향력이 가장 크고, 사회정체성(γ = .017)은 매우 작은 것으로 나타났으며, 직업 전환에는 진로자기효능감(β = .552)의 영향력이 가장 크고, 다음은 자아정체성(γ = .591), 사회정체성(γγ = -.002) 순으로 나타났다. 또한, 최종 구조모형의 교차타당성이 인정되었다. 둘째, 집단 간의 차이를 알아보기 위하여 잠재평균분석을 실시한 결과, 고연령 집단이 저연령 집단에 비해 직업 전환이 높은 것으로 나타났으며(p < .001), 비 선수출신 집단이 선수출신 집단에 비해 직업 전환이 높은 것으로 나타났다(p < .001). 또한 고경력 집단이 저경력 집단에 비해 직업 전환이 높은 것으로 나타났으며(p < .001), 은퇴 전 계획이 있는 집단이 없는 집단보다 자아정체성, 진로자기효능감, 직업 전환이 높은 것으로 나타났다(p < .001). 셋째, 최종모형의 적용성 검토를 위해 다중집단분석을 실시한 결과, 경력별에 따라 자아정체성에서 진로자기효능감과 사회정체성에서 직업 전환에 이르는 경로에서 고경력 집단이 저경력 집단에 비해 보다 강력한 영향을 미치고 있는 것으로 나타났으며, 은퇴 전 계획 유무별 집단에서는 자아정체성에서 진로자기효능감과 진로자기효능감에서 직업 전환에 이르는 경로에서 은퇴 전 계획이 있는 집단이 은퇴 전 계획이 없는 집단에 비해 보다 강력한 영향을 미치고 있는 것으로 나타났다. This study, which targeted professional cycle racers, aimed to develop a structural model explaining causal between factors having an effect on career transitions. It was conducted by 448 cycle racers in order to design a structural model. Methods of statistical analysis are: descriptive statistics, reliability statistics, exploratory factor analysis, confirmatory factor analysis, correlational relationship analysis, structural equation modeling analysis, latent mean analysis, multi-group analysis, etc. This study used SAS 9.1 and SPSS 18.0 AMOS 18.0 statistical analysis software program. the analytical results of this study are as follows. 1. As a result of an analysis about measurement model, career exploration behavior was deleted in the process of model modification by modification index and career maturity failed to reach inspection standard of reliability and validity, and was removed. Finally, the result of confirmatory factor analysis of 4 measurement models corresponding with reliability and validity met the requirement of most standards and thus this measurement model has been confirmed as valid. 2. Set goodness-of-fit-indexes of structural model based on 4 final measurement models which have been proven in reliability and validity came up to all the standards. As an analytical result of causal effect, career self-efficiency was the most powerful in self-identity(γ = .730) and was very small in social identity(γ = .017). In career transitions, career self-efficacy(β = .552), the most influential, followed by self-identity(γ = .591), and social identity(γ = -.002) were present in sequence. Also, final structural model was accepted as cross-validation. 3. For the search of differences between groups, a latent mean analysis was conducted. As a result, First, it showed that possibilities of older age athletes group were higher than those of younger age athletes group in career transition(ρ < .001). Secondary, chances of non-people of athletes group were higher than those of people of athletes group in career transition(ρ < .001). Thirdly, athletes group with much experience showed higher possibilites than athletes group with lack of experience in career transitions(ρ < .001). Fourth, athletes group with pre-retirement planning showed higher chances than athletes group without the plan in self-identity and career self-efficacy, and career transitions(ρ < .001). 4. The outcome of multi group analysis conducted for the review of application about final model revealed that by experience, in view of self-identity, career self-efficacy and in social-identity, the process of career transitions powerfully affected those who have much career compared with those who have less career. By groups of checking whether pre-retirement planning is or not, in terms of self-identity, career self-efficacy, and in career self-efficacy, the process of career transitions are much more influential for groups with pre-retirement planning than groups without one.