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- 저자 : 민경윤(Kyung Yoon Min) (검색결과 3 건)
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Tc-99m-MAA 를 이용한 간세포암의 경동맥 관류스캔
김강득,손광준,민경윤,권영미,김창근,노병석,원종진 ( Gang Deuk Kim,Kwang Joon Sohn,Kyung Yoon Min,Young Mi Kwon,Chang Guhn Kim,Byung Suk Noh,Jong Jin Won ) 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.3
Puryose : Hepatic arterial perfusion scintigraphy with Tc 99m macroggregated albumin (HAPS) study was carried out in 16 patients with hepatocellular carcinoma(HCC) and in six patients without liver tumor to evaluate HAPS findings of hepatocellular carcinoma and usefullness of HAPS, Materials and Methods : HAPS with planar and SPECT study were performed in 22 patients after conventional hepatic or celiac arteriography. For HAPS study, 4 5 mCi of MAA mixed with 2ml of saline was injected into proper hepatic artery or its distal branches at the rate of approximately 1ml/sec. We anatysed 21 HCCs over 2cm in diameter(average diameter : 6.4cm) and 17 of 21 HCCs were over 4cm in diameter(Table 1). CT, sonography and angiography were performed within two week in all 16 patients and liver scan was performed in 12 patients. Results : Three different pattern of tumor perfusion were observed in 16 pat.ients with HCC (Table 2), 1) diffuse increased perfusion in 16 of 21(76%)(Fig. 1) 2) increased peripheral perfusion in 4 of 21(19%)(Fig. 2) 3) diffuse decreased perfusion in 1 of 21(5%) Arteriovenous shunt indicated by lung uptake of MAA were observed in 9 of 16(56% ) (Fig. 4). In contrast, angiography demonstrates arteriovenous shunt in 2 of 16(13%). There was no accumulation of radioactivity on RRC blood pool scan in all six patients with HCC examined (Fig. 1). Conclusion : HAPS is useful study in evaluation of perfusion pattern or vascularity of HCC and in detection of arteriovenous shunt.
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Iodine - 131 - Iodomethyluridine을 이용한 종양세포증식의 영상화에 관한 실험적 연구
김창근(Chang Guhn Kim),원종진(Jong Jin Won),김현정(Hyun Jeong Kim),임형근(Hyung Guhn Lim),민경윤(Kyung Yoon Min),노지영(Ji Young Rho),정선관(Seon Kwan Juhng),양경문(David J . Yang) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.3
N/A Purpose: Noninvasive imaging of tumor cell proliferation could be helpful in the evaluation of tumor growth potential and could provide an early assessment of treatment response. Radiolabeled thymidine, uridine and adenosine have been used to evaluate tumor cell proliferation. These nucleoside analogs are incorporated into DNA during proliferation. Iodine-131-Iodomethyluridine, an analog of Iodine-131-Iododeoxyuridine, is also involved in DNA/RNA synthesis. The purpose of this study was to develop Iodine-131-Iodomethyluridine and image tumor proliferation using Iodine -131-Iodomethy-luridine. Materials and Methods: Radiosynthesis of Iodine-131-5-Iodo-2'-O- methyluridine(Iodine-131-Iodomethyluridine) was prepared from 10 mg of 2'-O-methyluridine (Sigma chemical Co., St. Louis, Missouri)-and 2.1 mCi(SP. 10Ci/mg) of Iodine-131-labeled sodium iodide in 100 μl of water using iodogen reaction. Female Fischer 344 rats were inoculated in the thigh area with breast tumor cells (13765 NF, 105 cells/rat S.C.). After 14 days, the Iodine-131- Iodomethyluridine 10μCi was injected to three groups of rats(3/group). The percent of injected dose per gram of tissue weight was detennined at 0.5-hours, 2-hours, 4-hours, and 24-hours respectively. Tumor bearing rats after receiving Iodine-131-Iodomethyluridine(50μCi/rat, IV) were euthanized at 2 hours after injection. Autoradiography was done using freeze-dried 50 μ m coronal section. After injection of Iodine-131-Iodomethyluridine (100μCi/rat, IV) in three breast tumor-bearing rats, planar scintigraphy was taken at 45 minutes, 90 minutes and 24 hours. Results: Iodine-131-Iodomethyluridine was conveniently synthesized using iodogen reaction. The biodistribution showed fast blood clearance and the tumor-to-tissue uptake ratios showed that optimal imaging time was at 2 hours postinjection. Autoradiogram and planar scintigram indicated that tumor could be well visualized. Conclusion: The findings suggest that Iodine-131- Iodomethyluridine, a new radio-iodinated nucleoside, has potential use for evaluation of active regions of tumor growth.
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상변화를 갖는 다공물질내의 유동 및 열전달 특성에 관한 연구
이진호,김홍제,민경윤 연세대학교 대학원 1987 延世論叢 Vol.23 No.1
An experimental investigation has been made to study the two-phase phenomena and heat transfer characteristics in porous media heated at the top and cooled at the bottom at one dimensional steady state. Experiment is conducted using glass beads and sand of mean diameter 0.9mm and 0.3mm respectively contained in a 22cm long, 5cm inner diameter Pyrex glass tube. Distilled water is used as a working fluid. Result of experiment shows that the two-phase zone is very sensitive to the system insulation and its length increases with the increasing heat flux, which is contrary to a pre-researcher. At this stage, this contradiction is supposed due to the variation of capillary pressure with the varying heat flux. The two·phase zone length of the lower permeability sand system is larger than that of the higher permeability system filled with glass beads. The total effective thermal conductivity of the system is enhanced with an increasing two phase zone length.
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