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과립구 감소 환자의 감염시 Imipenem/cilastatin 단독요법의 치료효과 : Piperacillin-amikin 병합요법과의 무작위 비교
송재훈,최승원,박수길,고윤석,서철원,이규형,이정신,문희법,김상희 대한화학요법학회 1991 대한화학요법학회지 Vol.9 No.2
To evaluate the efficacy of the single agent therapy for the initial management of fever in neutropenic patients, we conducted a prospective randomized trial comparing imipenem/cilastatin alone with a combination of piperacillin and amikacin. Among 40 evauable episodes of fever, stratum A(hematologic malignancy, n=30) consisted of 15 imipenem group and 15 piperacillin plus amikacin group and stratum B consisted of 10 cases with solid tumor. There was no difference in age, sex, duration of neutropenia, initial granulocyte count and number of cases with severe neutropenia(<100/㎣) between two groups. Overall response rate to imipenem was higher(86.6%) than combination therapy group(53.5%) in stratum A, but statistical difference was not found. Overall response rate to imipenem in solid tumor was 100% whereas to combination therapy group was 40%. There was no serious toxicity on imipenem use. We conclude that imipenem monotherapy could be an effective & safe empirical therapy in the treatment of febrile neutropenic patients.