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Mivacurium 과 Nitroglycerin 의 상호작용
한인수,이철우,홍창수,심재철,전정우,윤준로,문장혁,문호식 대한마취과학회 2001 Korean Journal of Anesthesiology Vol.40 No.2
Background: The neuromuscular blocking effects of a nondepolarizing neuromuscular blocker (NDNM) during a nitroglycerin (NTG) infusion were significantly potentiated and prolonged. NTG reduced the requirement of a NONM in surgical patients, We investigated the influence of a NTG single bolus injection on a mivacurium nuromuscular blockade. Methods: We studied 36 adult surgical patients, ASA physical status I or II, between 15 and 53 years old. Neuromuscular monitoring was measured by TOF-GUARD?? (Biometer Co., Denmark). Anesthesia was induced by thiopental sodium 3-5 mg/kg and fentanyl 3 ㎍/kg, and maintained with 3 L/min N2O, 2 L/min O2 and 1 vol.% isoflurane. Patients were randomly assigned to 3 groups: 1) Control group (mivacurium 0.16 mg/kg),2) N100 group (mivacurium 0.16 mg/kg, NTG 100 ㎍),3) N200 group (mivacurium 0.16 mg/kg, NTG 200 ㎍). We measured the train-of-four (TOF) response from the beginning of recovery to the complete regaining of muscle twitch. Results: NTG produced a prolongation of the neuromuscular blocking effect by mivacurium. T1 (contro group: 12.1 ± 0.5, N100 group: 15,8 ± 0.4 and N200 group: 11.6 ± 0.4 min),T25 (16.4 ± 0.4, 20.5 ± 0.5 and 14.9 ± 1.0 min), T75 (22.5 ± 0.9, 29.4 ± 0.7 and 20.1 ± 1.0 min),T95 (27.3 ± 0.6, 39.6 ± 0.7 and 24.6 ± 1.5 min) and the recovery index (6.1 ± 0.6, 9.0 ± 0.4 and 5.3 ± 0.7 min) were significantly prolonged in the N100 and N200 groups (P < 0.05). Conrlusion: These results suggest that a NTG bolus injection prolonged the neuromuscular blocking effect of mivacurium, dose relatively. (Korean J Anesthesiol 2001; 40: 163 ~ 168)