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침윤성 자궁경부암에서의 Membranous Type1, 2, 3-Metalloproteinase 발현
문혜성 ( Hye Sung Moon ),성순희 ( Soon Hee Sung ),정혜원 ( Hye Won Chung ),김승철 ( Seoung Cheol Kim ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.6
Objective: Threre are several proteolytic enzymes such as Matrix Metalloproteinases (MMP), which are involved in tumor invasion and metastasis. The aim of this study was to determine the exprssion of Membranous Type MMPs (MT-MMPs) and investigate the relationship between their expression and questioned whether their expression is related to stages and other prognostic factors of cervical cancer. Methods: The cervical and cervical cancer tissues were taken from the patients; healthy women (n=14), and the patients with cervical cancer (n=35). The protein expression of MT1, 2, 3-MMP with MMP-2 was examined using immunohistochemical staining and western blotting. MMP-2 activity was measured by zymogram. Results: The expression of MT1, 2, 3-MMP was higher in cervical cancer than that of normal cervix (p<0.05). No significant association was found between MT-MMPs and clinicopathologic factors, such as age, grade, stage, tumor sizes, and Squamous cell carcinoma-Ag (SCC-Ag) (p>0.05). But there were significant correlations between MT1-MMP, MT3-MMP and lymph node involvemen t (p<0.05). There was significant correlation between MT-MMPs and MMP-2 (p<0.05), too. Conclusion: According to the results, MT-MMP expression could be associated with the pathogenesis of cervical cancer. In addition, the evaluation fo MT-MMPs expression might be helpful to predict lymph node metastasis in cervical cancer. Further prospective study with a large number of cases is needed in future.
문혜성(Hye Sung Moon),최은아(Eun Ah Choi),정혜원(Hye Won Chung) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.4
Objectives : Interleukin-6 is a pleiotrophic cytokine that is not only a mediator in major immunologic reactions but also a growth factor of keratinocytes. We studied IL-6 mRNA expression in cervical cancer, CIN and normal cervix. And we questioned whether its expression is related to cervical carcinogenesis and other prognostic factors. Methods : The normal cervical and cervical cancer tissues were taken from healthy women (n=16), and the patients with CIN (n=36) and cervical cancer (n=36). The IL-6 mRNA expression was examined by quantitative competitive PCR after polymerase chain reaction amplification of reverse transcriptase copies of RNA transcripts (RT-PCR). Results : There was no statistically different among cervical cancer, CIN and normal cervix (p>0.05). The IL-6 mRNA expression was not different according to the grades of CIN. Its expression was not correlated with the stage of cervical cancer, size of tumor, and histopathologic type (p>0.05). Conclusion : These results suggested that IL-6 mRNA expression might not be associated with the cervical carcinogenesis and prognosis of cervical cancer.
침윤성 자궁경부암에서의 Matrix metalloproteinase-2 & -9, Tissue inhibitor of metalloproteinase-1 & -2 mRNA 발현
문혜성(Hye Sung Moon),최은아(Eun Ah Choi),유민영(Min Young Yoo),정혜원(Hye Won Chung) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.3
Objective : Invasive cancer cells penetrate the extracellular matrix(ECM), including basement membrane during the metastatic cascades. Matrix metalloproteinases(MMPs) play a critical role in tumor invasion and metastasis and their activities are regulated by specific tissue inhibitors of metalloproteinase(TIMPs). Aberrant ECM degradation in tumor biology is attributed to an imbalance in local MMP and TIMP activity, resulting in the overexpression or enhanced activation of MMPs or reduced TIMP expression. The aim of this study was to compare the MMP-2 & -9, TIMP-1 & -2 mRNA expression in cervical cancer with those in normal cervix and to investigate that their expression is related to cancer stages and other prognostic factors. Methods : The normal cervix and cervical cancer tissues were obtained from healthy women(n=14), and the patients with cervical cancer(n=31), respectively. Total RNA was extracted and reverse transcribed into cDNA. The expression of MMP-2 & -9, TIMP-1 & -2 mRNA was examined by quantative competitive PCR(QC PCR) and each results were analyzed by t-test and univariate analysis. Results : The expression of MMP-2, TIMP-1 mRNA in cervical cancer was higher than that in nomal cervix(p<0.05). The TIMP-2 mRNA expression was elevated in cervical cancer while that was not shown in normal cervix. The MMP-9 mRNA expression was not statistically different between normal cervix and cervical cancer(p>0.05). Conclusions : These results suggested that increased MMP-2, TIMP-1 & -2 mRNA expression is an early event during malignant transformation of cervical cancer.
문혜성(Hye Sung Moon),정혜원(Hye Won Jung),김무희(Moo Hee Kim),김연정(Youn Jung Kim),한운섭(Woon Sup Han) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11
Choriocarcinoma is a malignant tumor arising from chorionic villi following normal or abnormal gestation. It rarely originates in the extragonadal region such as retroperitoneum and mediastinum. In these extragonadal choriocarcinomas, primary gastric choriocarcinoma is extremely rare. A 37-year old woman with primary choriocarcinoma of the stomach presented with amenorrhea and anemia. Serum level of β-hCG was moderately elevated. There was gastric choriocarcinoma with histologic pattern of adenocarcinoma. We wish to report the extremely rare finding of a choriocarcinoma occurring as a primary gastric neoplasm with gynecologic symptom.
침윤성 자궁경부암에서 β - & α - Catenin 과 focal Adhesion Kinase 발현에 관한 연구
문혜성(Hye Sung Moon),최은아(Eun Ah Choi),정혜원(Hye Won Chung),김승철(Seung Cheol Kim) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.8
Objective : E-cadherin/catenin adhesion complex is fundamentally involved in epithelial cancer invasion and metastasis. Focal adhesion kinase (FAK) is one of the molecules that may be involved in the regulation of focal adhesion integrity and the progression of cancer to invasion and metastasis. The present study was aimed to explore that the β- & α-catenin might be involved in the invasion and metastasis of cervical carcinoma, and their expression might be related with other clinicopathologic factors or associated with FAK in cervical cancer. Methods : The tissues were obtained from the 26 patients with cervical carcinoma and the 9 patients with normal cervix undergoing hysterectomy. The proteins were extracted and the expression of β- and α-catenin and FAK were studied with a western blot analysis. The coexpression of α-catenin and FAK was examined with an immunoprecipitation. The clinicopathologic factors were reviewed with the charts of patients and the results were analysed with the Chi-square test and Spearman`s correlation test. Results : The expression of β- and α-catenin in cervical carcinoma was lower than that in normal cervix (p<0.05). Their expression was not correlated with other clinicopathologic factors. The expression of FAK in cervical carcinoma was related with the expression of α-catenin. Conclusion : This study showed that the expression of β- & α-catenin is involved in the invasion of cervical carcinoma and the FAK expression might be associated with the a-catenin expression in cervical carcinoma.
문혜성(Hye Sung Moon),최진영(Jean Yung Chey) 대한노인정신의학회 2004 노인정신의학 Vol.8 No.2
Objectives:This study examined the effects of illiteracy on neuropsychological functions of older Korean adults. Illiteracy was evaluated with the Literacy Questionnaire which involved interview with the subjects. Methods:The participants were 206 healthy people, ages between 55 and 84, who were sampled in the Seoul-Kyungki region and Chungnam province. Results:The results revealed that verbal memory tests were not disadvantageous to illiterate people. Rather non-verbal tasks such as the copy condition of the Simple Rey Figure Test and the Clock Drawing Test proved disadvantageous. Conclusion:Literacy appears to be beneficial to the development of visuospatial abilities. Neuropsychological tests that involve visuospatial function may not be efficient in discriminating dementia patients who are illiterate.