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문재연,김원,김주한,안영근,정명호,김영학,홍명기,박성욱,박승정,박성하,고영국,최동훈,장양수 연세대학교의과대학 2008 Yonsei medical journal Vol.49 No.3
Purpose: This study was designed as a multicenter, randomized, open-label study to evaluate the efficacy and tolerability of Clotinab™. We expected to obtain same results as with ReoPro in improving ischemic cardiac complications in high-risk patients who were about to undergo percutaneous coronary intervention (PCI). Patients and Methods: Patients of 19 -80 years of age with acute coronary syndrome (ACS) who were about to undergo PCI were enrolled. After screening and confirmation of eligibility, patients were randomly assigned to different groups. Clotinab™ was given to 84 patients (58.7± 10.6 years, M:F=68:16) and ReoPro (59.0±10.5 years, M:F=30:10) was given to 40 patients before PCI. The primary efficacy endpoint was the onset of major adverse cardiac event (MACE) within 30 days from day 1. The tolerability endpoints were assessed based on bleeding, thrombocytopenia, change in Hb/Hct, human antichimetric antibody development, and adverse events. Results: The number of ClotinabTM patients experiencing MACE was 0 out of 76 per protocol (PP) patients. The MACE rate was 0%, and its 95% exact CI was [0.00- 4.74%]. A major bleeding event developed in 3 patients in the ReoPro group. The probability of MACE onset in Clotinab™ was estimated to be less than 5%. There was no clinically significant result in tolerability variables. Conclusion: ClotinabTM is an effective and safe medicine in preventing ischemic cardiac complications for high-risk patients who will receive PCI.
Increase of Metabolic Syndrome Score is an Independent Determinant of Increasing Pulse Pressure
문재연,박성하,안철민,조정래,박찬미,고영국,최동훈,정명호,장양수,정남식 연세대학교의과대학 2008 Yonsei medical journal Vol.49 No.1
Purpose: The objective of this study was to determine whether the progressive increase of metabolic syndrome (MetS) score, the number of components of MetS, is correlated significantly with increasing pulse pressure (PP). Materials and Methods: 4,034 subjects were enrolled from the Cardiovascular Genome Center of Yonsei University (M:F=2344: 1690, 55.2±10.5). Most of the study population were recruited from hypertension clinics, controlled with medications according to JNC7 guidelines. The Asian modified criteria of MetS were applied and MetS score was estimated. The HOMA index for insulin resistance, cholesterol profiles, and anthropometric measurements were assessed. Results: Among 4034 participants, 1690 (41.9%) were classified as MetS. Progressive increase in PP was demonstrated for increasing components of the MetS score. Multiple linear regression analysis with PP as the dependent variable showed that age (β=0.311, p<0.001), MetS score (β=0.226, p<0.001), male gender (β=-0.093, p <0.001) and HOMA index IR (β=0.033, p=0.03) are significantly associated with PP (R2=0.207, p<0.001). Conclusion: The present results from this study demonstrate that increasing MetS score is an independent determinant of increasing PP. The results also demonstrate the independent role of MetS in increasing arterial stiffness and PP.
문재연,정해창,심두선,박형욱,홍영준,김주한,안영근,정명호 대한심장학회 2008 Korean Circulation Journal Vol.38 No.7
The anomalous origin of the right coronary artery is a rare condition, but it has clinical importance because there have been reports of nonfatal or fatal myocardial infarction and sudden death associated with exercise for patients with this anatomy. We describe here a patient for whom 64 channel multi-detector row computed tomography was useful to identify this anomaly, and intravascular ultrasound was used to evaluate the myocardial ischemia by visualizing the coronary lumen. The anomalous origin of the right coronary artery is a rare condition, but it has clinical importance because there have been reports of nonfatal or fatal myocardial infarction and sudden death associated with exercise for patients with this anatomy. We describe here a patient for whom 64 channel multi-detector row computed tomography was useful to identify this anomaly, and intravascular ultrasound was used to evaluate the myocardial ischemia by visualizing the coronary lumen.
TAXUSTM 스텐트 시술 후 스텐트 혈전증 발생률과 임상경과
문재연,정명호,김인수,전충환,조정선,정종원,심두선,홍영준,김주한,안영근,조정관,박종춘,강정채 대한심장학회 2007 Korean Circulation Journal Vol.37 No.12
Background and Objectives : Findings from randomized controled trials have showed that there is no diference in the development of stent thrombosis (ST) -eluting stents (DES) as compared to the use of bare metal stents. The aim of this study was to evaluate the incidence, clinical characteristics, and cli-nical outcome of ST after implantation of TAXUSTM stents in routine clinical practice. Subjects and Methods : This was a retrospective, single center cohort study. The study included 1,584 patients that underwent sucessful TAXUSTM stent implantation (2,513 lesions treated) betwen May 2004 and Dec 2006. Results: ST developed in 18 patients (1.14%) (0.06%), subacute ST occured in nine patients (0.57%), and late ST developed in eight patients (0.51%). Sixteen patients that developed ST re-ceived medication with dual antiplatelet agents. The incidence of ST in patients with acute coronary syndrome (ACS) showed was higher than in patients with stable coronary disease. The mean folow-up duration for pa-tients was 13.3 months. There were 13 myocardial infarctions and 3 deaths attributable to ST. Conclusion : The TM stent implantation in consecutive real-world patients was substantially higher than the rate reported in clinical trials. Patients with ACS should be treated more aggressively as the risk of stent thrombosis is higher than for patients with stable angina. A large prospective study for the identification of predictors of DES thrombosis should be conducted. (Korean Circ J 2007 ;37:641-646) 배경 및 목적 최근 들어 실제 임상에서는 스텐트 혈전증의 빈도가 대규모의 계획된 임상연구들보다는 높다는 보고가 있으며 실제 임상에 계획된 임상연구의 결과들을 일률적으로 적용하는 것은 옳지 않다는 주장이 제기 되었다. 본 연구는 실제 임상에서 TAXUSTM스텐트를 삽입 받은 환자들을 대상으로 스텐트 혈전증의 빈도를 알아보고 이의 임상적 특징 및 치료 후의 경과에 대해서 알아보고자 진행되었다. 방 법 본 연구는 단일기관 후향적인 연구로 204년 5월부터 206년 12월까지 29개월간 전남대학교병원 심장센터에서 TAXUSTM스텐트를 성공적으로 시술 받은 총 1,584명 (2,51 병변)을 연구대상으로 하였다. 결 과 총 1,584명 중 18명 (1.14%)의 환자에서 스텐트 혈전증이 발생하였으며 병변의 수로는 0.72% (18/2511)의 빈도로 발 생하였다. 급성 스텐트 혈전증은 1명 (0.06%)에서, 아급성 스 텐트 혈전증은 9명 (0.57%)에서, 후기 스텐트 혈전증은 8명 (0.51%)에서 발생하였다. 스텐트 혈전증이 발생한 환자 중 16 명 (88.9%)에서 aspirin과 clopidogrel을 복용하고 있던 중에 발생하였다. 스텐트 혈전증의 임상적 발현 또한 심근경색증 으로 발현되는 경우가 13명 (72.2%)이었으며, 이 중 3명이 사망하였다. 결 론 TAXUSTM 스텐트 혈전증의 발생빈도는 실제 임상에서 1.14% 이었으며, 관상동맥 조영술로 확인을 하지 못한 채 사망한 경우 등 스텐트 혈전증이 의심되는 probable 혹은 possible stent thrombosis까지 고려한다면 실제 임상에서의 TAXUSTM 스텐트 혈전증의 빈도는 기존의 연구 결과 보다는 높을 것 으로 사료된다.
STAR FORMATION ACTIVITY OF GALAXIES UNDERGOING RAM PRESSURE STRIPPING IN THE VIRGO CLUSTER
문재연,황호성,Myung Gyoon Lee,정애리,Hyein Yoon,Jong Chul Lee 한국천문학회 2021 Journal of The Korean Astronomical Society Vol.54 No.1
We study galaxies undergoing ram pressure stripping in the Virgo cluster to examine whether we can identify any discernible trend in their star formation activity. We first use 48 galaxies undergoing different stages of stripping based on HⅠ morphology, HⅠ deficiency, and relative extent to the stellar disk, from the VIVA survey. We then employ a new scheme for galaxy classification which combines HⅠ mass fractions and locations in projected phase space, resulting in a new sample of 365 galaxies. We utilize a variety of star formation tracers, which include g - r, WISE [3.4]-[12] colors, and starburstiness that are defined by stellar mass and star formation rates to compare the star formation activity of galaxies at different stripping stages. We find no clear evidence for enhancement in the integrated star formation activity of galaxies undergoing early to active stripping. We are instead able to capture the overall quenching of star formation activity with increasing degree of ram pressure stripping, in agreement with previous studies. Our results suggest that if there is any ram pressure stripping induced enhancement, it is at best locally modest, and galaxies undergoing enhancement make up a small fraction of the total sample. Our results also indicate that it is possible to trace galaxies at different stages of stripping with the combination of HⅠ gas content and location in projected phase space, which can be extended to other galaxy clusters that lack high-resolution HⅠ imaging.