외래 천식 환자의 polypharmacy 현황 분석을 통한 약물 사용의 적정성 평가

문용현,안혜림,한옥연,나현오 한국병원약사회 2011 病院藥師會誌 Vol.28 No.1

Since 2001, the Health Insurance Review & Assessment Service(HIRA) analyzed the ratio of prescriptions more than 6 medications and assessed overprescribing of medications, however, there has been some controversies on its validity as the contents of the assessment was based on the total amount. Therefore, the objective of this study is to analyze polypharmacy status and evaluate appropriateness of prescriptions in asthma patients, one of chronic diseases with the highest ratio of prescriptions more than 6 medications, and to suggest some recommendations to improve current evaluation criteria. Based on the prescriptions for asthma outpatients from department of pulmonology since April 1, 2009 to June 30, we’ve classify the data into prescriptions more than 6 medications and those less than 6 medications and compared appropriateness by ratio of reliever prescription, which are advised for all patients according to GINA guideline, ratio of inappropriate prescription of controller, and ratio of therapeutic duplications. A total number of prescription was 371 and the average number of medications per prescription was 4.9 and 35.6% had more than 6 medications. The reliever prescribed ratio was 56.8% in prescription more than 6 items and 49.0% with less than 6 items(p=0.1467), accordingly, and the ratio of inappropriately prescribed controller is 13.6% and 8.8%(p=0.1448), so there is no any significant differences between these two groups. The ratio of therapeutic duplications for prescriptions with more than 6 items are 40.2% and for those less than 6 items are 9.6%(p<0.0001), mostly expectorants, antihistamines, and cough remedy. In addition, asthma medications, respiratory symptomatic medications, digestive medicines, and other disease medications appeared higher for prescriptions more than 6 medications(p<0.0001), so all items appeared as a reason for increased number of medications. In conclusion, the appropriateness of asthma prescriptions more than 6 medications is not different from that with less than 6 medications, except therapeutic duplication. Therefore, they’re suggested to develop criteria which based on not only the quantity of medications, but also the quality of pharmacotherapy. And they should consider the severity of the disease and co-morbidity of other disease when evaluating medications for asthma patient and must improve a way to avoid those duplicated prescription such as expectorants, antihistamines, and cough remedy.

스마트팩토리에서 시뮬레이션을 하기 위한 가상 데이터 생성기 연구

문용현,황승연,신동진,김정준 한국인터넷방송통신학회 2021 한국인터넷방송통신학회 논문지 Vol.21 No.1

스마트팩토리는 4차 산업혁명에서 가장 대두되는 분야라고 말할 수 있다. 스마트팩토리에 필요한 공정이나 알고 리즘을 개발하는 데에는 필수적으로 스마트팩토리에서 나오는 데이터값들이 필요하지만 그러한 데이터를 얻기 위해서는 현실적으로 많은 어려움이 있다. 따라서 본 연구에서는 스마트팩토리에 관한 연구를 돕기 위해 스마트팩토리 속 여러 공정의 데이터들을 보다 현실적으로 시뮬레이션할 수 있는 데이터 생성기를 개발하였다. 추가로, 설정 프리셋과 직관적 인 UI 구성 등, 데이터 생성자의 편의를 위한 기능들도 개발하였다. 이 데이터 생성기를 이용함으로써, 스마트팩토리 환경에 필요한 여러 시스템을 만들 때 현실적인 데이터를 손쉽고 간단하게 생성하여 스마트팩토리 환경을 시뮬레이션하 는 데 많은 도움을 받을 수 있을 것이다. It can be said that smart factory is the most prominent area in the fourth industrial revolution. Developing processes or algorithms required for smart factory requires data values from smart factory, but there are many real challenges in obtaining such data. Therefore, this study developed a data generator that can more realistically simulate data from different processes in smart factory to help research on smart factory. In addition, functions such as setting presets and intuitive UI configurations were developed for the convenience of data creators. This data generator will help you simulate smart factory environments by providing more realistic data easily and simply when you create the different systems needed for smart factory environments.

영상정보와 도시정보체계 : 주제강연 / 국토모니터링체계 구축계획

문용현 한국지형공간정보학회 2001 2001 학술발표 세미나 Vol.- No.-

유일식별자 부여를 위한 건물객체의 효율적인 중첩방안 연구

문용현(Moon Yong Hyun),박기석(Park Ki Surk),최석근(Choi Seok Keun) 대한공간정보학회 2011 대한공간정보학회지 Vol.19 No.2

1995년 이후 국가지리정보구축사업의 일환으로 전국적으로 구축되었던 공간정보시스템의 통합과 연계에 대한 연구가 끊임없이 이어지고 있다. 하지만 공간정보연계와 통합을 위한 체계적인 기준이 모호할 뿐만 아니라 각각의 구축기관마다 공간정보에 대한 식별 ID가 상이하게 구축되어 있어 연계에 어려움을 주고 있는 실정이다. 본 연구에서는 국가표준의 공간정보참조체계를 기반으로 하는 UFID를 부여하기 위해 공간정보객체의 중첩방안을 제시하고 이에 대한 중첩률을 분석하고자 한다. After 1995, as a part of national geographic information system project, there are a lot of researches about combinations and connections of national geographic information system. However, systematic standard for combinations and connections of geographic information is uncertain, and each organization has different identification system which leads to difficulties in connection of geographic information system. This study suggests repeating method about geographic information objects to grant UFID based on national standards of geographic information system, and analyzes the repeating rate.

수도재배시 담수심 처리에 따른 배출부하량 비교

문용현 ( Moon Yong Hyun ),윤춘경 ( Yoon Chun Gyeng ),황하선 ( Hwang Ha Sun ) 한국농공학회 2002 한국농공학회 학술대회초록집 Vol.2002 No.-

The purpose of this study was to investigate the effects of ponding depth treatment on water balance in paddy fields. Three ponding depth treatment, shallow, traditional, and deep were used. Daily values of rainfall amount, ponding depth, irrigation water, drainage water, evapotranspiration, and infiltration were measureed in the field. The results showed that irrigation water depths were 198mm, 195mm, and 355mm in shallow, traditional, and deep ponding, respectively. The three treatments did not show any statistical difference in growth and yields. Shallow depth treatment showed the largest yield.

공간매칭을 이용한 수치지도의 속성정보 생성

문용현(Moon, Yong Hyun),김명석(Kim, Myoung Suk),조의환(Jo, Eui Hwan),최석근(Choi, Seok Keun) 대한공간정보학회 2012 대한공간정보학회지 Vol.20 No.3

수치지도는 국가에서 시행하고 있는 도로명주소를 포함 하지 못하고 있으며, 타 기관에서 직접 활용하기에는 문제점이 있어 연계 구축이 필요하나, 기 구축된 수치지도와 도로명 주소의 양이 방대하여 매칭을 수작업으로 진행할 경우 많은 예산 및 시간이 필요한 실정이다. 본 연구는 공간매칭을 이용하여 수치지도와 도로명주소의 자료 연계를 통하여 속성정보를 생성 하는 시스템을 개발하고, 이에 대한 매칭률을 분석하고자 한다. 대상지역에 대한 매칭율을 분석한 결과 수원시는 1:1000수치지도에서 건물이 84%, 도로가 67%로 좋은 매칭율을 나타냈고, 서귀포시는 건물 18%, 도로 21%로 나타났다. The construction of data connection is required due to the digital map do not have the new address data which is implemented by the Korea government and it cannot use between government and other agency. The manually matching of digital map and new address data is time and money consuming process due to the huge amount of data. In this research, new system is developed for data generation of attribute data by the data connection method of digital map and new address data using spatial matching and matching rate of data connection is analyses. The results of data matching rate in the research area are 84% in building case and 67% in road case in 1:1000 digital map at Suwon and 18% in building case and 21% in road at Seogwipo.

약물의 폐 전달을 위한 염화 벤제토늄 기반 리포좀의 제조 및 평가

문용현, 유소열, 안지선, 이한솔, 김혜림, 이은주, 이재영 충남대학교 약학대학 의약품개발연구소 2021 藥學論文集 Vol.36 No.-

Benzethonium chloride-containing egg phosphatidylcholine-based liposomes (BC/EPC-LIPOs) were developed for lung-targeted drug delivery. BC/EPC-LIPOs were fabricated via thin-film hydration method with various BC-to-EPC molar ratios of 1:4 (F1), 1:1 (F2), and 4:1 (F3). Cyanine5.5 (Cy5.5) was loaded as a fluorescent probe for the biodistribution study during the film-forming step. BC/EPC-LIPOs were evaluated by using dynamic light scattering analysis, where the mean diameter and zeta-potential values of F1, F2, and F3 were observed to be 69.5 ± 3.1 nm and 50.06 ± 1.00 mV, 59.0 ± 2.3 nm and 51.30 ± 2.98 mV, and 694.2 ± 243.3 nm and 55.01 ± 3.16 mV, respectively. To evaluate the lung distribution efficiency of the developed liposomes, F1 and F2, which possess suitable particle sizes for the intravenous administration, were injected into the tail vein of ICR mice. At 6 h post-injection, the lung, liver, kidney, heart, spleen, and brain were dissected, and the radiant efficiency (RE) values of the or- gans were measured using the near-infrared fluorescence imaging method. The lung RE value of F2 was 1.69-fold higher than that of F1, indicating a more efficient lung targetability of F2. This phenomenon can be attributed to the higher content of BC in F2 than F1. Considering the lung-targetability, as well as the biocompatible natures of BC and EPC, the developed BC/EPC-LIPOs can be used as an efficient lung-targeted drug delivery system.

HPLC를 이용한 백삼,홍삼,홍삼농축액의 유리당 성분 및 함량 확인

맹주양;이용구;이숙재;정진아;황규찬;김태희;문용현 순천향대학교 기초과학연구소 2010 순천향자연과학연구 논문집 Vol.16 No.2

Free sugars-Fructose, Glucose, Sucrose, Maltose-were isolated from white ginseng, red ginseng, and red ginseng concentrate by HPLC. The results for the content of sugar was as follows: in white ginseng, Sucrose(30.70ppm) > Maltose (7.45ppm) > Fructose(0.42ppm) > Glucose(0.22ppm), in red ginseng, Maltose(33.65ppm) > Sucrose(8.84ppm) > Fructose (0.81ppm) > Glucose(0.43ppm), and in red ginseng concentrate, Sucrose(14.12ppm) > Fructose(9.23ppm) > Maltose(6.86ppm) > Glucose(5.87ppm). Overall results suggest that, in the contents of sugar, monosaccharide(Glucose) is lowest and disaccharide(Sucrose, Maltose) is highest, in all of ginseng.

실존적 건축공간의 결정화에 관한 연구

박한규,문용현 대한건축학회 1994 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.14 No.2

LDA 기반 사용자 감정분석을 위한 문서 토픽 추출 시스템에 대한 연구

안윤빈,김학영,문용현,황승연,김정준 한국인터넷방송통신학회 2021 한국인터넷방송통신학회 논문지 Vol.21 No.2

최근 IT 분야의 주요 기술인 빅데이터는 다양한 산업 분야로 확장되고 있으며 활용 방안에 대한 연구가 활발하게 진행 중이다. 대부분의 인터넷 산업 분야에서 사용자 리뷰는 이용자가 상품 구매를 결정하는 데 많은 도움을 준다. 그러 나 방대한 제품 리뷰에서 긍정, 부정적 의미와 도움이 되는 리뷰를 선별하는 과정은 제품 구매 결정에 있어 많은 시간을 요구한다. 따라서 본 논문에서는 빅데이터 분석 기술인 LDA를 이용해 키워드를 분석 및 종합하여 사용자에게 의미 있는 정보를 제공하는 시스템을 설계하고 구현한다. 문서 토픽 추출을 위해 본 연구에서는 국내 도서 산업을 도메인으로 데이 터를 크롤링하고, 빅데이터 분석을 실시한다. 이를 통해 사용자 리뷰의 토픽 및 감정단어를 바탕으로 상품에 대한 종합적 인 정보를 제공함으로써 구매자에게 도움을 주고 나아가 리뷰 현황 분석을 통해 상품의 전망 또한 파악할 수 있다. Recently, big data, a major technology in the IT field, has been expanding into various industrial sectors and research on how to utilize it is actively underway. In most Internet industries, user reviews help users make decisions about purchasing products. However, the process of screening positive, negative and helpful reviews from vast product reviews requires a lot of time in determining product purchases. Therefore, this paper designs and implements a system that analyzes and aggregates keywords using LDA, a big data analysis technology, to provide meaningful information to users. For the extraction of document topics, in this study, the domestic book industry is crawling data into domains, and big data analysis is conducted. This helps buyers by providing comprehensive information on products based on user review topics and appraisal words, and furthermore, the product's outlook can be identified through the review status analysis.