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아토피피부염이 영유아의 식품알레르기 자연경과에 미치는 영향
박지선 ( Ji Sun Park ),문순정 ( Soon Jeong Moon ),임대현 ( Dae Hyun Lim ),장해지 ( Hae Ji Jang ),황선영 ( Sun Young Hwang ),박윤성 ( Yoon Sung Park ),김정희 ( Jeong Hee Kim ) 대한천식알레르기학회(구 대한알레르기학회) 2017 Allergy Asthma & Respiratory Disease Vol.5 No.5
Purpose: There have been studies showing that food allergy plays a role in the pathogenesis of atopic dermatitis. However, there have been few studies about the effect of atopic dermatitis on remission of food allergy. Thus, this study aimed to evaluate the dif-ference in remission according to the presence of atopic dermatitis in infants and young children with milk or egg allergy. Methods: A retrospective study was performed on 109 infants and young children with IgE-mediated food allergy in a tertiary hos-pital. They divided into food allergy with atopic dermatitis (FA with AD) and without atopic dermatitis (FA without AD). Results: In the milk allergy group, initial milk-specific IgE levels were 21.16±27.98 kU<sub>A</sub>/L and 11.36±22.88 kU<sub>A</sub>/L, respectively, in FA with AD and FA without AD under 12 months of age. The remission rates of milk allergy at 36 months of age were 64.9% and 90.0%, respectively, in FA with AD and FA without AD. In the egg allergy groups, initial egg-specific IgE levels were 34.48±36.72 kU<sub>A</sub>/L and 15.66±28.60 kU<sub>A</sub>/L, respectively, in FA with AD and FA without AD under 12 months of age. The remission rates of egg allergy at 36 months of age were 61.2% and 90.0% in children with FA with AD and FA without AD. Conclusion: Atopic dermatitis may play an important role in the natural history of food allergy in infants. Different strategies are needed for the management of food allergy in young children with atopic dermatitis. (Allergy Asthma Respir Dis 2017;5:256-261)
사염화탄소에 의하여 유발된 흰쥐의 간 독성에 미치는 비테인의 효과
김선여(Sun Yeou Kim),김홍표(Hong Pyo Kim),이미경(Mi Kyeong Lee),변순정(Soon Jeong Byun),김승희(Seung Hee Kim),문애리(A Ree Moon),한형미(Hyung Mi Han),허훈(Hoon Huh),김영중(Young Choong Kim) 대한약학회 1993 약학회지 Vol.37 No.5
Effects of betaine, a major component of Lycii Fructus, on carbon tetrachloride intoxicated rats were evaluated. Histological studies showed that betaine had improved the typical necrosis around centrilobular area in liver tissue due to the carbon tetrachloride intoxication. Betaine, whether it was administrated simultaneously or prior to carbon tetrachloride, prevented or retarded the elevation of liver-weight/body-weight ratio due to the carbon tetrachloride intoxication. Betaine also significantly elevated the reduced activities of some enzymes, cytochrome P-450, 7-ethoxycoumarin-O-deethylase and glutathione-S-transferase, involved in xenobiotic metabolism due to carbon tetrachloride intoxication. These results demonstrate a possible hepato-protective role of betaine against fatty liver that could be easily induced by carbon tetrachloride in rat.