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몇 가지 항균제가 시험관내에서 내독소와 TNF-α, IL-6 분비에 미치는 영향
최정현,문건웅,김명훈,이동건,박윤희,김상일,김태연,유진홍,김양리,신완식,강문원 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.2
To evaluate antibiotic-induced endotoxin release(AIER) and its correlation with some cytokines, we measured endotoxin level and tumor necrosis factor alpha(TNF-α) and interleukin6(IL-6) production in mononuclear cells in vitro after exposure of Pseudomonas aeruginosa to antibiotics belonging to different class with two extreme concentrations. The tested concetration of antibiotics were set up according to peak serum level. The low concetration of ceftazidirne and low concentration of imiperiem increased AIER, but high concentration of ceftazideme, high concentration of ciprofloxacin, high concentration of cefoperazone/sulbactam, high concentration of amikacin, and high concentration of meropenem reduced AIER.Interestingly, combined treatment of these antibiotics markedly reduced AIER, But the major cyotkines, TNF-α and IL-6 were not affect by type and concettration of antibiotics, combined treatment of antibiotics, and level of endotoxin released by antiboitics. In this study, we observed AIER was different according to type of antibiotics, concentration of antibiotics, and combination of antibiotics, But AIER had poor correlation with TNF-α and IL-6 in Pseudomonas aeruginosa. It suggests that cytokine release is not solely dependent to endotoxin, but more complex cascade is needed. More invesfigations, such as endotoxin induced cytokine mRNA expression, relationship with penicillin-binding proteins and endotoxin-neutralizing effect of antibiotic itself, must be performed.
김성래,김석영,이영재,김태연,문건웅,윤성노,이종민,안석주,방병기,서광선 대한내과학회 1997 대한내과학회지 Vol.53 No.3S
저자들은 민물에 빠진후 4일간의 오심, 구토를 동반한 복통을 주소로 내원한 22세 남자 환자에서 조직 검사상 허혈성 급성 신부전으로 증명된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. A number of complications may arise in patients who survive episodes of near-drowing. After aspiration of fresh water, extensive hemolysis, anoxia and hypotension occur, and may predispose a patient to the development of acute tubular necrosis, which is a recognized complication of near drowning in fresh water. A 22-year-old man was admitted to hospital with abdominal pain for 4 days following an episode in which near drowning while swiming in the river. We determined that he was in acute renal failure. The renal biopsy revealed acute tubular necrosis (ATN) and we suspected that the cause of ATN was hypoxemia. To our knowledge, this is first report of ATN by near drowning in Korea. We report the case and the review of the literature.
이상준,박순민,이영석,한남익,윤종구,이종민,한석원,문건웅,윤인재,천지성,정정조,서백종 대한소화기학회 1998 대한소화기학회지 Vol.30 No.5
Background/Aims: The Krukenberg tumor is a metastatic or primary ovarian tumor of the signet-ring cell type. The incidence of this tumor are high in Korea, especially among relatively young age group, and the prognosis is poor. Therefore we tried to understand the relationship between the many factors and survival periods. Methods: We have observ d 12 cases of Krukenberg tumors from January 1984 to February 1997 in Holy Family Hospi:al and analyzed them. Results: The Krukenberg tumor accounts for 14.1% among the 85 malignat ovarian tumor and 3.5% among the 342 female gastric cancers found in our hospital during this period. The age distribution of the patients ranged from 25 to 50 years of age and the majority were under 40 years of age. The mean age was 34.2 years. Initial chief complaints were epiga.tric pain, lower abdominal pain, and lower abdominal mass. The sizes of Krukenberg tumors range from 7.2cm to 18.0cm and the tumors were usually bilateral. From diagnosis to death, the mean duration of survival was 6.7 months. But it was 9.0 months in cases where an operation on the ovaries and the primary site, were performed. In the group of ascites(8 cases), it was 2.6 months contrary to 14.8 months of ascites-free group. Conclusions: The prognosis of the Krukenberp tumor depends on early diagnosis and aggressive treatrnent.