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STANDARDS IN APRIL 보건의 날 - 의료기기 제조사에 대한 국가적 지원과 신뢰성 확보해야
맹은호,Maeng, Eun-Ho 기술표준원 2011 기술표준 Vol.110 No.-
4월 7일은 세계보건기구(WHO) 발족을 기념하는 '세계 보건의 날'이다. 고령화사회가 됨에 따라 의료기기 시장이 커지고 있다. 국제표준화 동향에 대한 조사 분석과 정보를 관련 산업체에 제공하는 등 의료기기 국제경쟁력 확보를 위한 지원이 필요하다.
상황버섯(Phellinus linteus) 자실체 분비물의 면역활성 및 항암효과
맹은호,이연태,조규봉,홍승희,Maeng, Eun-Ho,Lee, Yun-Tai,Cho, Kyu-Bong,Hong, Seung-Hee 대한면역학회 2002 Immune Network Vol.2 No.2
Background: The chemical characteristics of the exo-secretion from Phellinus linteus (referred to as exo-secretion) including the compositions of amino acids and monosaccharides were investigated. In addition, cytotoxicity of the exo-secretion on 5 tumor cell lines derived from human cancers and its antitumor activity against ascitic sarcoma-180 cells were examined. Methods: The antitumor activity of exo-secretion from Phellinus linteus was determined by measuring parameters including tumor weight, life span of mice, chemotatic activity of leukocytes, counts of immune cells, and activity of cytokines. Results: The exo-secretion from Phellinus linteus showed no direct cytotoxicity to the five tumor cell lines tested, but it had a strong antitumor activity against sarcoma-180 cells in ICR mice as measured by tumor weight and life span of mice. The exo-secretion stimulated the chemotaxis of leukocytes and production of immune cells and cytokines. Conclusion: These results suggest that the exo-secretion from Phellinus linteus do not act as a direct cytotoxic substance to cancer cells but as an immunomodulator.
04 포스터 발표 : 토양 환경 분야(PS) ; PS-12 : 서로 다른 토양에서 Imidacloprid의 흡착 및 탈착 특성
이창호 ( Chang Ho Lee ),남지윤 ( Ji Youn Nam ),권회군 ( Hoe Gun Kwon ),이제형 ( Je Hyeong Lee ),송은희 ( Eun Hee Song ),추환용 ( Hwan Yong Choo ),맹은호 ( Eun Ho Maeng ) 한국환경농학회 2015 한국환경농학회 학술대회집 Vol.2015 No.-
Imidacloprid는 chloronicotinyl계 침투성 살충제로서 흡입해충(sucking insects), 토양해충(soil insects),흰개미(termites), 저작해충(chewing insects) 등을 방제할 목적으로 사용되고 있다. 그러나, 꿀벌(Apismellifera)에 대하여 독성이 매우 높고, LD50이 8 ng/bee로 보고 되어 있다. 그리고, 토양내에서 imidacloprid의 수착(sorption) 정도는 유기탄소 및 무기물질 등의 영향을 많이 받는 것으로 알려져 있다. 따라서, 본 연구에서는 서로 다른 토양에서 imdacloprid의 흡/탈착특성을 알아보고, 토양내 거동형태를 파악하고자 하였다. HCB-SL-PF (silty loam, pH 6.8, OC 33.0 g kg-1), Iowa Soil (silty loam, pH6.2, OC 8.5 g kg-1)의 두 종류의 토양을 선정하였으며, 흡/탈착실험을 위하여 토양과 용액비율을 1:3(w/v)으로 하여 Imidacloprid를 0, 5, 10, 50, 100, 500 mg kg-1 수준으로 처리하여 상온에서 20 rpm의 속도로 4시간 진탕하였다. 산출된 결과를Freundlich equation에 적용한 일차식으로 나타내었고, 흡착실험에서 HCB-SL-PF 토양은 기울기 0.807 (R2 0.980), KadsF 1.897, Iowa Soil 토양은 기울기 0.950 (R20.998), KadsF 1.359로 나타났다. 탈착실험에서는 HCB-SL-PF 토양은 기울기 0.582 (R2 0.924), KadsF3.461, Iowa Soil 토양은 기울기 0.977 (R2 0.917), KadsF 1.390로 나타났다. 상대적으로 유기탄소함량이 높은 HCB-SL-PF (OC 33.0 g kg-1) 토양이 Iowa Soil (8.5 g kg-1) 토양보다 흡착계수가 높게 나타났다.
문지영 ( Ji Young Moon ),맹은호 ( Eun Ho Maeng ),박학수 ( Hak Soo Park ),권민 ( Min Kwon ),장동혁 ( Dong Hyouk Jang ),조영민 ( Young Min Cho ),고은옥 ( Eun Ok Koh ),성하정 ( Ha Jung Sung ),박철범 ( Cheol Beom Park ) 한국동물실험대체법학회 2007 동물실험대체법학회지 Vol.1 No.1
Reconstructed skin provides advantages to single cell culture testing and leads to promising results as shown by different validation studies. In this study we investigated the efficacy of "MCTT Skin model" compared with "EPI-200" and in vivo test. We conducted endpoint analysis including cell viability (MTT reduction, CCK-8) and IL-1 alpha release. Sodium lauryl sulfate(20%), Potassium hydoxide(5%), Heptanal, Methyl palmitate, 1,1,1-Trichloroethane, 2,4-Xylidine, 3,3`-Dithiodipropionic acid, 4-Amino-1,2,4-triazol and Benzyl chloroformate were selected for this comparison. Potassium hydoxide(5%) and Benzyl chloroformate were excluded from animal tests because of their pH. Sodium lauryl sulfate induced severe irritation, Heptanal induced moderate irritation. Methyl palmitate, 1,1,1-Trichloroethane induced mild irritation. 2,4-Xylidine, 3,3`-Dithiodipropionic acid, 4-Amino-1,2,4-triazole induced no irritation on rabbit skin irritation test. Results of MTT assay and CCK-8 assay were not different between EPI-200 MCTT Skin model but IL-lα levels of some test items different between EPI-200 and MCTT Skin model. We concluded that this MCTT Skin model is useful for alternative skin irritation test, although other tests should be conducted for many other chemicals in international validation study.
문지영 ( Ji Young Moon ),맹은호 ( Eun Ho Maeng ),박학수 ( Hak Soo Park ),권민 ( Min Kwon ),장동혁 ( Dong Hyouk Jang ),조영민 ( Young Min Cho ),고은옥 ( Eun Ok Koh ),성하정 ( Ha Jung Sung ),박철범 ( Cheol Beom Park ) 한국동물실험대체법학회 2007 동물실험대체법학회지 Vol.1 No.1
Reconstructed skin provides advantages to single cell culture testing and leads to promising results as shown by different validation studies. In this study we investigated the efficacy of MCTT Skin model compared with EPI-200 and in vivo test. We conducted endpoint analysis including cell viability (MTT reduction, CCK-8) and IL-1 alpha release. Sodium lauryl sulfate(20%), Potassium hydoxide(5%), Heptanal, Methyl palmitate, 1,1,1-Trichloroethane, 2,4-Xylidine, 3,3`-Dithiodipropionic acid, 4-Amino-1,2,4-triazol and Benzyl chloroformate were selected for this comparison. Potassium hydoxide(5%) and Benzyl chloroformate were excluded from animal tests because of their pH. Sodium lauryl sulfate induced severe irritation, Heptanal induced moderate irritation. Methyl palmitate, 1,1,1-Trichloroethane induced mild irritation. 2,4-Xylidine, 3,3`-Dithiodipropionic acid, 4-Amino-1,2,4-triazole induced no irritation on rabbit skin irritation test. Results of MTT assay and CCK-8 assay were not different between EPI-200 MCTT Skin model but IL-lα levels of some test items different between EPI-200 and MCTT Skin model. We concluded that this MCTT Skin model is useful for alternative skin irritation test, although other tests should be conducted for many other chemicals in international validation study.
송정민,백홍,이승영,장동혁,서무엽,박길종,맹은호,Song, J.M.,Baek, H.,Lee, S.Y.,Jang, D.H.,Seo, M.Y.,Park, G.J.,Maeng, Eun-Ho 대한의용생체공학회 2013 의공학회지 Vol.34 No.2
The goal of this study is to develop test method for evaluating the drug eluting properties of drug eluting stents (DES). PBS and the detergent solutions, presented by each DES manufacturer, were used for drug release of DES coated with paclitaxel, zotarolimus and everolimus. The drugs which are coating DES were not released by PBS but released by the detergent solutions, finally paclitaxel 83.38%, zotarolimus 103.85% and everolimus 115.78%. It seems that the use of the detergents is necessary in order to release the drugs because those drugs are extremely hydrophobic. In conclusion, using of detergent solutions presented by each manufacturer were suitable for evaluating the drug eluting property of drug eluting stent.
연구논문 : 유전독성 대체시험법(in vitro소핵시험)의 국내검증시험연구
이현걸 ( Hyun Kul Lee ),김종극 ( Jong Geuk Kim ),이우주 ( Woo Joo Lee ),맹은호 ( Eun Ho Maeng ),이종윤 ( Jong Yoon Lee ),정영신 ( Young Shin Chung ),김창환 ( Chang Hwan Kim ),김윤순 ( Yun Soon Kim ),장미해 ( Mi Hae Jang ),이석종 ( 한국동물실험대체법학회 2011 동물실험대체법학회지 Vol.5 No.1
This validation study was performed to introduce and set up the in vitro micronucleus test, as an alternative to the existing chromosome aberration test, in the test facilities in Korea, and to establish the competence of each facility to perform the in vitro micronucleus test independently. The 10 coded substances, including 6 positive and 4 negative in genotoxicity assay, were tested. Six facilities were divided into two subgroups, A and B. Three coded positive compounds and two negative compounds were sent to each test facility. The compounds were tested according to the facility`s GLP system. In group A, positive results were obtained from testing of the three positive compounds, and negative results were obtained from testing of the two negative compounds in all three facilities. In group B, positive results were also obtained from testing of the three positive compounds, and negative results were obtained from testing of the two negative compounds in all three facilities. For the Urethane, an in vitro equivocal compound tested by group B, negative results were obtained. These results suggested that the compound may be effectively activated only in in vivo environment. The results show that the six test facilities are capable of performing the in vitro micronucleus test independently and producing consistent results.
유전독성 대체시험법(in vitro소핵시험)의 국내검증시험연구
이현걸 ( Hyun Kul Lee ),김종극 ( Jong Geuk Kim ),이우주 ( Woo Joo Lee ),맹은호 ( Eun Ho Maeng ),이종윤 ( Jong Yoon Lee ),정영신 ( Young Shin Chung ),김창환 ( Chang Hwan Kim ),김윤순 ( Yun Soon Kim ),장미해 ( Mi Hae Jang ),이석종 ( 한국동물실험대체법학회 2011 동물실험대체법학회지 Vol.5 No.1
This validation study was performed to introduce and set up the in vitro micronucleus test, as an alternative to the existing chromosome aberration test, in the test facilities in Korea, and to establish the competence of each facility to perform the in vitro micronucleus test independently. The 10 coded substances, including 6 positive and 4 negative in genotoxicity assay, were tested. Six facilities were divided into two subgroups, A and B. Three coded positive compounds and two negative compounds were sent to each test facility. The compounds were tested according to the facility`s GLP system. In group A, positive results were obtained from testing of the three positive compounds, and negative results were obtained from testing of the two negative compounds in all three facilities. In group B, positive results were also obtained from testing of the three positive compounds, and negative results were obtained from testing of the two negative compounds in all three facilities. For the Urethane, an in vitro equivocal compound tested by group B, negative results were obtained. These results suggested that the compound may be effectively activated only in in vivo environment. The results show that the six test facilities are capable of performing the in vitro micronucleus test independently and producing consistent results.
김남준 ( Nam-jun Kim ),곽주현 ( Ju-hyun Kwak ),김지호 ( Ji-ho Kim ),이재형 ( Jae-hyung Lee ),황범구 ( Beom-goo Hwang ),맹은호 ( Eun-ho Maeng ),선일식 ( Yle-shik Sun ) 한국환경분석학회 2016 환경분석과 독성보건 Vol.19 No.2
In compliance with the Ministry of Environment’s Asbestos Safety Management Act (enforced on 4. 28. 2012), the building owners are required to carry out asbestos building survey. Depending on the results of the surveys, the owners of such buildings need to implement necessary measures such as repairs, sealing, or closure of the relevant areas. In this study, a test for asbestos scattering limit on asbestos head lining and scattering tests before and after applying a scattering inhibitor on a subject target were implemented. The result of the asbestos scattering limit test confirmed the possibility of asbestos scattering on both the front and back side of the interior material. Tests regarding the efficiency of the scattering inhibitor showed that in the absence of the scattering inhibitor, the detected asbestos concentration exceeded the limit prescribed as per the indoor air quality guidelines; however, with the application of two types of scattering inhibitors, the asbestos concentration in the indoor air was less than the prescribed limit. These results confirmed that the asbestos scattering inhibitor is effective in suppressing the spattering of asbestos; however, it will be necessary to have regulatory controls such as the obligatory use of scattering inhibitor after development of which can prevent all asbestos scattering inhibitor. The results of this study are expected to be utilized as base data for both the maintenance and development of various management programs aimed at an effective maintenance of asbestos building material.