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白鼠의 腦內 Opiate Receptor 日中 變動에 미치는 Scopolamine의 影響
마기환,고명규,김기원,조규박,한규송 전북대학교 의과학연구소 1986 全北醫大論文集 Vol.10 No.4
To investigate the influence of scopolamine on the diurnal variations of opiate receptor binding, the amount of specifically bound(3H)-morphine and β-endorphin were measured in the midbrain of rat at 4-hr intervals in a day. Animals were housed and adapted to a controlled cycle of either 12-hr light, 12-hr dark, or 240hr constant darkness. After 3 weeks of adaptation, vehicle or scopolamine(10mg/kg/day) or methscopolamine was administered intraperitoneally twice a day for 2 weeks. Highly significant rhythms of opiate receptor binding was found with peak at 22:00-hr and 06:00-hr in control group. Even in the absence of time cues these circadian rhythms persisted with peak at 02:00-hr and 14:00-hr and the rhythms were highly modified with respect to the wave forms as well as to the timing of peak and nadir. In the scopolamine-treated group, these diurnal rhythms were also modified in shape, phase and amplitude, as well as in timing of peak and nadir, In this group, 24-hr mean of opiate receptor binding was significantly increased and immunoreactive β-endorphin content was significantly decreased. But in the methscopolamine-treated group, 24-hr mean of maximum(3H)-morphine binding, β-endorphin content or other characteristics of circadian rhythm were not changed. However, Kd values, affinity index of receptors, were not changed in all experimental groups, indicating that the differences in binding were due not to changes in affinity but to changes in the number of binding sites. Statistical analysis of regression lines revealed a close inverse correlation between change of both receptor binding and β-endorphin content. These results indicate that scopolamine may affect the diurnal rhythm of opiate receptors by changing β-endorphin content and may influence the action of morphine by changing the number of opiate receptor in central nervous system.