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임상연구 : 고실유양동삭개술 시 Dexamethasone과 Ondansetron의 단독 또는 병용 투여가 수술 후 오심구토 예방에 미치는 효과
류우리 ( Woo Ri Ryu ),이정삼 ( Jung Sam Lee ),권재영 ( Jae Young Kwon ),김철홍 ( Chul Hong Kim ),장현수 ( Hyum Soo Jang ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.52 No.5
Background: Postoperative nausea and vomiting (PONV) is the major cause of patient`s discomfort after surgery. Dexamethasone and ondansetron have been known to have some preventive effects on PONV. The purpose of this study was to compare the effects combination therapy of these drugs in the prevention of PONV after tympanomastoidectomy which has been known to be a high risk factor of PONV. Methods: Ninty patients scheduled tympanomastoidectomy under general anesthesia were included. Patients were randomly divided into three groups and received dexamethasone 5 mg (group D), ondansetron 4 mg (group O), or dexamethasone 5 mg plus ondansetron 4 mg (group DO) at 30 min before the end of operation. The degree of PONV was assessed at 6 h, 12 h, 24 h, and 48 h after operation. Results: The degrees of nausea in group DO during 0-6 h and 6-12 h were lesser than those of other groups. The overall incidences of nausea were 73% (group D), 62% (group O), and 23% (group DO, P < 0.05). The degrees of vomiting in group O and DO during 0-6 h were lesser than those of group D. The overall incidences of vomiting were 37% (group D), 17% (group O), and 7% (group DO, P < 0.05). Conclusions: The combination of dexamethasone and ondansetron is more effective than single use of each drug for the prevention on PONV after tympanomastoidectomy. (Korean J Anesthesiol 2007; 52: 556~60)
어깨관절 내 Bupivacaine 주입 후 발생한 심정지 -증례 보고-
윤원기,이정삼,장현수,조영훈,류우리 대한마취통증의학회 2009 Anesthesia and pain medicine Vol.4 No.1
Intra-articular administration of local anesthetics such as bupivacaine can produce short-term postoperative analgesia in patients who are undergoing shoulder arthroscopy. Yet bupivacaine can result in cardiovascular toxicity that can lead to cardiac arrest. We experienced a case of 63-year-old male patient with severe cardiac toxicity that led to ventricular fibrillation 15 minutes after injecting 0.5% bupivacaine into the patient’s shoulder joint for shoulder arthroscopy.