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애엽추출물 , DA-9601 의 실험적 위궤양 모델에 대한 항궤양 효과 및 기전 연구
양중익(Junn Ick Yang),이상득(Sang Deuk Lee),이은방(Eun Bang Lee),오태영(Tae Young Oh),류병권(Byung Kweon Ryu),박정배(Jeong Bae Park) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.2
Antiulcer effects of Artemisia herbs extract (DA-9601) were evaluated in various types of experimental gastric ulcer induced in rats. And the effects of DA-9601 on mucus, basal and stimulated gastric acid secretion were also investigated in rats. DA-9601 (12.5∼400 ㎎/㎏, p.o.) prevented the formation of gastric ulcers induced by 60% EtOH in 150 mM HCl, restraint water immersion stress, platelet activating factor (PAF), aspirin in 150 mM HCl with Pylorus-ligation and indomethacin. DA-9601 (4∼400 ㎎/㎏, p.o.) significantly accelerated the healing rate of acetic acid-induced gastric ulcer and significantly stimulated mucus secretion in a dose-dependent manner. DA-9601 (20∼200 ㎎/㎏, i.d.), however, did not inhibit basal gastric acid secretion in pylorus ligated rats and DA-9601 (200 ㎎/㎏, i.d.) failed to influence histamine-, pentagastrin- and carbachol- stimulated gastric acid secretion. These results suggest that DA-9601 has inhibitory action on gastric lesion and ulceration through increasing mucus secretion in the stomach of rats without influencing basal and stimulated gastric acid secretion.
새로운 아드리아마이신유도체 DA-125 의 조혈기독성과 함암효과에 미치는 G-CSF 의 영향
안병옥(Byoung Ok Ahn),김원배(Won Bae Kim),양중익(Junn Ick Yang),이상득(Sang Deuk Lee),류병권(Byung Kweon Ryu) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.2
The present study was designed to evaluate the effects of a recombinant human granulocytecolony stimulating factor (G-CSF) on leukopenia and tumor growth in mice treated with DA-125, an adriamycin (ADM) derivative. In normal mice, single intravenous injection of DA-125 produced transient leukopenia accompanied with weight loss and splenic atrophy in a dose-related manner. However, subcutaneous administration of G-CSF (5 ㎍/head) for 5 consecutive days after DA-125 resulted in a significantly elevated nadir of leukocyte counts and facilitation of recovery from the leukopenia. To investigate the effect of G-CSF on antitumor effects of DA-125, ADM (12 mg/kg) or DA-125 (40 mg/kg) was administered to Colon-26 murine adenocarcinoma-bearing Balb/c mice with G-CSF. Regardless of treatment with G-CSF, DA125 and ADM markedly retarded the growth of implanted tumor, though they failed to increase mean survival time of tumor-bearing mice. These results suggest that G-CSF is able to not only ameliorate, but reconstitute DA-125-induced myelosuppression without affecting its antitumor potential.
에탄올 - 유발 위점막손상에 대한 애엽추출물 (DA-9601) 의 방어효과 및 기전에 관한 연구
안병옥(Byoung Ok Ahn),김원배(Won Bae Kim),김순회(Soon Hoe Kim),이은방(Eun Bang Lee),오태영(Tae Young Oh),류병권(Byung Kweon Ryu),고준일(Jun Il Ko),손미원(Mi Won Son) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.2
Protective effect of DA-9601, an extract of Artemisia Herb, against ethanol-induced gastric mucosal injury was evaluated in rats. In the prophylactic study, DA-9601 exhibited total protection (99.4%) against absolute ethanol-induced gastropathy. And the protective effect of DA-9601 lasted up to 2 hours, which was longer than those of other contemporary mucoprotectants. In the treatment study, DA-9601 significantly facilitated the healing of 70% ethanol-induced mucosal damage, which was superior to cetraxate, a commonly used anti-ulcer drug. The mechanisms of mucoprotection of DA-9601 were also assessed. DA9601 increased the release of prostaglandin E₂ from murine neutrophils in a dose-dependent manner in vitro. The cytoprotective effect of DA-9601 against ethanol-induced mucosal damage was significantly diminished by the concommitant injection of N_w-nitro-L-arginine methyl ester (L-NAME, 5 mg/kg, i.v.), a non-specific nitric oxide (NO) synthase inhibitor, while it was not affected by preinjection of indomethacin (5 mg/kg, s.c.), a prostaglandins-depletor. And it was found that DA-9601 significantly enhanced adaptive cytoprotective action of 10% ethanol against absolute ethanol (56.9±6.5 vs 23.0±3.3 mm², p<0.05, mean±SEM), though its exact underlying mechanism remains to be clarified. The present findings demonstrate that DA-9601 exerts gastroprotective actions for the stomach against ethanol through several different underlying mechanisms, in which prostanglandins and NO are involved. In conclusion, the results obtained suggest that DA-9601 can be useful both in prevention and treatment of ethanol-induced gastric damage.