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헬리코박터 파이로리 치료 실패 후 레보플록사신을 이용한 3차 구제요법의 기간에 따른 제균율
노형민 ( Hyung Min Noh ),홍수진 ( Su Jin Hong ),한재필 ( Jae Pil Han ),박경우 ( Kyung Woo Park ),이윤나 ( Yun Nah Lee ),이태희 ( Tae Hee Lee ),고봉민 ( Bong Min Ko ),이준성 ( Joon Seong Lee ),이문성 ( Moon Sung Lee ) 대한소화기학회 2016 대한소화기학회지 Vol.68 No.5
Background/Aims: This study evaluated the eradication rate of levofloxacin-containing rescue therapy by treatment duration in patients in whom previous first- and second-line treatment failed. Methods: Fifty-five patients with persistent Helicobacter pylori infection after first-line therapy and second-line therapy were studied in a single referral academic center. We compared the eradication rates by the treatment duration of third-line therapy. Results: Of 55 patients, 12 (21.8%) received rescue therapy for seven days, 24 (43.6%) received rescue therapy for 10 days, and 19 (34.5%) received rescue therapy for 14 days. The eradication rates of therapy with levofloxacin were 65.5% in the 55 enrolled patients and 73.5% in the 49 patients who underwent follow-up testing. In cases where follow-up testing was performed, the eradication rate of 7-day therapy was 58.3%, of 10-day 68.2%, and of 14-day therapy 93.3%. Eradication rate of 14-day therapy was higher than 7-day (p=0.06) and 10-day (p=0.108), but chance could not be ruled out in the difference among groups. Conclusions: This study showed somewhat increasing of H. pylori eradication rate by extending the duration of levofloxacin-containing rescue therapy to 14 days. (Korean J Gastroenterol 2016;68:260-264)