단시간 허용농도의 toluene이 benzene대사에 미치는 영향

노재훈,신동천,박정균,문영한,정호근,Roh, Jae-Hoon,Shin, Dong-Chun,Park, Jung-Gyun,Moon, Young-Hahn,Chung, Ho-Keun 대한예방의학회 1988 Journal of Preventive Medicine and Public Health Vol.21 No.1

Benzene and toluene, which are widely used aromatic hydrocarbons in workplace, are recently proved to cause health hazards due to their toxic effects. This study investigated the influence of toluene on the urinary excretion of benzene metabolite by administering short term exposure limit(STEL) of these compounds(i.e., 13.8mg/kg of benzene and 108.8 mg/kg of toluene) intraperitoneally into Sprague-Dawley rats. After administration, urinary phenol concentration of rat was measured by gas chromatography for every three hours. Data were analyzed by non-parametric statistical methods using Kruskal-Wallis multi-sample test and Mann-Whitney U test. The following results were obtained : 1. Administration of STEL-benzene increased urinary phenol concentration in lats. 2. Urinary phenol concentration was increased logarithmically according to the dosage of benzene. 3. Excretion of phenol in urine was decreased when benzene and toluene were administered simultaneously compared with administering benzene alone. In summary, these results reveal that administration of STEL of toluene has antagonistic effect of urinary excretion of benzene metabolite in rats.

일부지역 탄광 착암 근로자의 진동증후군 유병율

노재훈,Roh, Jae-Hoon 대한예방의학회 1981 Journal of Preventive Medicine and Public Health Vol.14 No.1

Due to rapid industrialization and economic development, the occupational diseases have appeared as one of the social problems in Korea. Up until now little has been known about the prevalence rate, predisposing factors and symptomatology of the occupational disease due to localized vibration in Korea. The researcher intends to investigate the prevalence rate and affecting factors of the occupational disease due to localized vibration among rock-drillers in the anthracite mines. A total of 135 rock-drillers were interviewed and examined from May 15th to 31th, 1980. The results were revealed as follows; 1. The prevalence rate of the vibration syndrome among rock-drillers was 12.6%. 2. The latent period of the vibration syndrome was 6.8 years. 3. The prevalence rate of the vibration syndrome was not significantly different between smokers and non-smokers. 4. With the increase of total vibration exposure time, the prevalence rate of the vibration syndrome increased also. 5. The average vibration sensation threshold was high (6.4dB) in stage 1 of the vibration syndrome and low (-0.6dB) in stage 0. 6. The average pain sensation threshold was high (4.4g) in stage 1 of the vibration syndrome and low (2.5g) in stage 0.

소음이 백서 혈압 및 맥박수에 미치는 영향

노재훈,신동천,차봉석,문영한,Roh, Jae-Hoon,Shin, Dong-Chun,Cha, Bong-Suk,Moon, Young-Hahn 대한예방의학회 1984 Journal of Preventive Medicine and Public Health Vol.17 No.1

The vascular reaction such as the indirect blood pressure and the pulse rate of the tail to the noise were examined in 8 naive Sprague-Dawley rats of both sexes. The sounds used in the experiment were 1KHz and 4 KHz, 95dB pure tone generated by Nagashima Audiometry. The indirect blood pressure and the pulse rate were checked at the rat tail by Polygraph at 5 minutes interval. The results were as follows: 1. The blood pressure and the pulse rate increased maximally 5 minutes after the exposure to both sounds. 2. The blood pressure and the pulse rate returned normal range within 20 minutes after the exposure of both sounds. 3. The increment of the blood pressure and the pulse rate was greater after the sound of 4KHz than after that of 1KHz, but it wasn't statistically significant.

진동공구 사용근로자의 피부온도 변화

노재훈,문영한,신동천,차봉석,조수남,Roh, Jae-Hoon,Moon, Young-Hahn,Shin, Dong-Chun,Cha, Bong-uk,Cho, Soo-Nam 대한예방의학회 1988 Journal of Preventive Medicine and Public Health Vol.21 No.2

충청북도 단양지역 착암 근로자 79명과 착암기를 사용하지 않는 광산 근로자 39명을 대상으로 1987년 6월 10일부터 1987년 6월 19일까지 면접 조사 및 집단 검사를 시행하여 다음과 같은 결과를 얻었다. 1. 창백지(white finger)는 오른쪽 손에 더 많이 나타났다. 2. 창백지 발현에 진동 노출량, 연령, 음주 및 흡연 여부가 통계학적으로 유의한 변수로 선정되었다. 3. 진동 증후군 증상자의 수지부 통각역치가 대조군에 비해 증가되었다. 4. 냉수 침적후 진동 증후군의 피부온도가 대조군에 비해 낮았으며 회복은 대조군에 비해 지연되는 경향을 보였다. By implementing epoch-making policies for industrial promotion, the national economy has made a remarkable development. As a result of such economic growth, industrial accidents and occupational diseases have become a serious problem in Korean society. In the presidential order for the execution of the Korean Labor Standard Law, neuritis and other diseases stemming from health impairments due to vibrations in industrial processes are designated to be dealt with as vibration diseases. In the case of vibration disease, industrial accident compensation is not effectively paid. In order to investigate the vibration hazards of rock-drill operation, the authors studied the subjective symptoms and performed physical function tests on a total of 79 persons (vibration exposed group) who used rock-drills, and 39 persons (control group) who did not use rock-drills at anthracite mines. The results of the physical function test were as follosws : 1. The right hand was more affected by white finger than the left hand. 2. Independent variables such as duration of rock-drill operation, age, drinking and smoking were indentified as statistically significant factors for the occurrence of white finger. 3. In the pain sense threshold, the group with Raynaud's phenomenon showed a statistically higher level than that of the control group. 4. The skin temperature of the group with Raynaud's phenomenon was lower than that of the control group. The recovery time of skin temperature aftr cooling was delayed compared with the value of the control group.

Binary CDMA 센서 네트워크에 적합한 보안 프로토콜 설계

노재훈(Jae Hoon Roh),문호건(Ho Kun Moon) 한국통신학회 2009 한국통신학회 학술대회논문집 Vol.2009 No.6

n-Hexane 및 Benzene이 백서 경골신경에 미치는 영향

이영수,노재훈,문영한,Lee, Young-Soo,Roh, Jae-Hoon,Moon, Young-Hahn 대한예방의학회 1987 Journal of Preventive Medicine and Public Health Vol.20 No.2

n-Hexane and benzene are organic compounds which have been widely used as industrial solvents. However, they are also increasingly recognized as important pollutants in working environment. The purpose of this study is tp analyze neurotoxicity of benzene and n-hexane. In this study, tibial nerve of Sprague-Dawley rats were observed after exposing them to two different concentrations of these compounds (6000 ppm of n-hexane and 2000 ppm of benzene) which were known to be the levels to cause subacute toxicity for the three different periods; two weeks, four weeks, and six weeks. The following results were obtained from the analysis of variance, Duncan's multiple comparison test, and regression analysis: 1) Myelin sheath thickness of nerve fiber for two n-hexane exposed groups (four weeks and six weeks) were both reduced compared with the control group and the benzene exposed group. 2) There were positive relationships between nerve fiber diameter and myelin sheath thickness for both exposed and control groups. 3) There was no significant difference in myelin sheath thickness from equal diameter nerve fibers between benzene exposed group and control group, but the greater number of thin myelin sheath were observed for n-hexane exposed group compared with control group. Thus, it is concluded that n-hexane tends to reduce the rate of growth of nerve fiber more than the benzene and control group. While these results shed light on understanding the effects of benzene and n-hexane, the duration of exposure was not long enough to apply these results to real working environments. In addition, to further understand the mechanims of nerve degeneration caused by organic solvents, both epidemiological and biochemical studies should accompanied by this kind of study.

건강진단 대상질환 선정 및 건강진단의 정확성 평가

유승흠,노재훈,이해종,정상혁,Yu, Seung-Hum,Roh, Jae-Hoon,Lee, Hee-Jong,Jung, Sang-Hyuk 대한예방의학회 1989 Journal of Preventive Medicine and Public Health Vol.22 No.1

The purpose of this study was to select the manageable diseases which are prevalent in Korea for periodic health examinations and to evaluate the sensitivity and specificity of periodic health examination in detecting these diseases. The data was derived from reimbursement data of the Korea Medical Insurance Corporation over a two year period (April 15, 1986 to April 14,1988) and interviews with Yonsei Medical School professors. This study demonstrated that: 1. The manageable diseases which were selected for periodic health examinations are pulmonary tuberculosis, viral hepatitis, diabetes mellitus, syphilis groups, essential hypertension, renal disease groups, and iron deficiency anemia. 2. The sensitivity of the health screening for each disease was as follows: pulmonary tuberculosis 51.5%, viral hepatitis 60.3%, diabetes mellitus 64.7%, syphilis groups 63.3%, essential hypertension 49.9%, renal disease groups 44.0%, and iron deficiency anemia 80.9%. We conclude that peiodic health esaminations should focus on the manageable diseases that we have defined. The number of items in periodic health screening tests and hospital quality control should be increased for the diseases with a demonstrated low sensitivity.

톨루엔 취급 근로자의 건강장해

문영한,노재훈,Moon, Young-Hahn,Roh, Jae-Hoon 대한예방의학회 1986 예방의학회지 Vol.19 No.2

Subjective symptoms, counts of blood cells and liver function test were conducted on 198 male workers who were exposed to toluene in Kyungin area from September to November, 1986. According to the level of urinary hippuric acid concentration, the total sample was classified into the high exposure group ($concentration{\geqq}3g/1$) and the low exposure group(concentration<3g/1). The following findings were obtained by comparing the two group: 1) Contrary to the previous findings. the urinary hippuric acid concentration of toluene exposed workers showed bimodal distribution. It meant that the toluene exposed workers were mixed with the non-exposed or minimal exposed workers. 2) The high exposure group showed a lower level of leucocytes counts ($6,630{\pm}1,860{\mu}l$) than the low exposure group ($6,340{\pm}1,960/{\mu}l$). 3) The high exposure group showed a higher level of SGOT, SGPT and r-GTP than the low exposure group (p<0.05). 4) The high exposure group complained much more subjective symptoms (e. g. skin rash, loss of appetite, palpitation) than the low exposure group.

의과대학 예방의학 성적의 비교 분석

유승흠,노재훈,정상혁,남정모,Yu, Seung-Hum,Roh, Jae-Hoon,Jung, Sang-Hyuk,Nam, Chung-Mo 대한예방의학회 1989 Journal of Preventive Medicine and Public Health Vol.22 No.2

The purpose of this study was to find a better evaluation methody by comparison and analysis of the subdivision-score for preventive medicine with other subjects and the total score. Among the 475 students who were second grade in 1983, 1984 and 1985, we analyzed the stores for all subjects at Yonsei University College of Medicine obtained by 443 students, with the exception of 32 students who had had a temporary absence from school, failed or had been expelled. And we analyzed the score for preventive medicine of 162 students who were second grade in 1987 and 179 students who were second grade in 1988. Statistical analysis of the above data was done using the correlation analysis, chi-square test and discriminating index. The results were as fellows: 1. The correlations of the subdivision of preventive medicine in 1984, 1987 and 1988 were statisticall significantly high(r=0.36-0.56). 2. The grades obtained for preventive medicine and for other subjects except pediatrics (clerkship) were not independent. 3. The discriminating indices that determined whether or not a pertinent evaluation was made were 0.42 in 1983, 0.52 in 1984 and 0.54 in 1985. These results were classified as excellent. These results suggest that the score of a subject is determined not by the characteristics of the subject, but by the amount of personal study.

인천지역 중소규모 사업장들의 보건관리대행제도에 대한 인식 및 태도

박종연,노재훈,김규상,이경종,문영한,Park, Chong-Yon,Roh, Jae-Hoon,Kim, Kyoo-Sang,Lee, Kyung-Jong,Moon, Young-Hahn 대한예방의학회 1993 Journal of Preventive Medicine and Public Health Vol.26 No.1

To investigate perception and attitude toward Group Health Management and Service System for Small and Medium Industries, a survey using self-administered questionnaire was conducted to a part of industries in Inchon, at October 1992. Major dependent variables were perception, attitude, and practice related with Group Health Management and Service System; these variables were measured by 3-point Likert like scale consisted of 7, 5, and 5 items, respectively. Data were collected in 149 industries,72.7% out of 205. Perception nab slightly high, 1.25; attitude was some positive, 1.46; and practice was some passive,0.94. Major determinants of perception, attitude, and practice were sex and age of industry's health manager; perception influenced upon attitude, and perception and attitude had positive effect upon practice. To activate Group Health Management and Service System, it is necessary to develop education and promotion programs for industry's health managers of small and medium industries.