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담즙정체성 간섬유증에서 헬리코박터 파일로리균 감염의 병리효과
노윤석(Yoon Seok Roh),임채웅(Chae Woong Lim),김범석(Bum seok Kim) 대한약학회 2017 약학회지 Vol.61 No.1
Accumulating evidence implicates Helicobacter pylori (H. pylori) could be an exacerbating factors in liver diseases. However, local hepatic immune response induced by H. pylori infection is poorly understood. To clarify immunopathological effect of H. pylori infection on the progression of hepatic fibrosis, C57BL/6 mice were orally inoculated with H. pylori (1×108 CFU/100 μl) for 16 weeks and liver fibrosis was then induced by bile duct-ligation (BDL). H. pylori infection induced increased number of regulatory T cells (Tregs) in the liver, chronic hepatitis, and upregulation of profibrogenic cytokine (TGF-β and IL-6) levels in the liver. In addition, the expression of MCP-1, MIP-1α and RANTES, potent mediator of macrophage and T lymphocyte recruitment, were increased in H. pylori-infected liver. Consistently, we found that H. pylori+BDL-treated mice had enhanced hepatic fibrosis and fibrogenic immune responses compared to BDL-treated mice. Finally, H. pylori-induced profibrogenic responses were significantly suppressed in TLR4 knockout mice, indicating that H. pylori-induced liver fibrosis is dependent on TLR4 signaling. These results are in line with the conclusion that H. pylori-associated Treg and TLR4 responses are, at least in part, responsible for the development of liver fibrosis.
좀작살나무 잎 추출물의 Echinacoside, Poliumoside, Isoacteoside 및 Acacetin-diglucuronide 동시 함량분석
김은남(Eun-Nam Kim),이다은(Da Eun Lee),이원진(Won Jin Lee),김태연(Tae Yeon Kim),노윤석(Yoon-Seok Roh),정길생(Gil-Saeng Jeong) 한국생약학회 2023 생약학회지 Vol.54 No.4
Callicarpa dichotoma (Lour.) K. Koch has a number of ingredients that are recognized to have physiological activity in hematuria, rheumatism, inflammation, and other conditions. Although study on the contents of C. dichotoma has not yet been done, it is known that the principal constituents are chemicals from the flavonoid and phenylethanoid glycoside class. Consequently, in this work, the amounts of echinacoside, poliumoside, isoacteoside and acacetin-diglucuronide found in the C. dichotoma leaf extract were measured utilizing a diode array detector in high-performance liquid chromatography (HPLC). HPLC was used to carry out the content analysis of each component, and tests for accuracy, specificity, and precision were used to validate the analysis technique. The result showed that the calibration curves of the four compounds, echinacoside, poliumoside, isoacteoside and acacetin-diglucuronide, a large linearity with a correlation coefficient (R²) of 0.9935, 0.9909, 0.9906 and 0.9934. Intra and inter day measurement accuracy of the four compounds was 94.56 to 117.77% and showed precision was less than 3%. Therefore, content analysis showed that echinacoside (1.75±0.28%), poliumoside (4.82±0.66%), isoacteoside (1.40±0.18%) and acacetin-diglucuronide (6.38±0.11%).