http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
신정활,정진화,남효영,김성원,조동우,임근배 한국바이오칩학회 2015 BioChip Journal Vol.9 No.1
Cartilage regeneration is a major challengefor researchers because cartilage tissue has limitedinnate regenerative ability. Encapsulation within analginate gel has been used widely for 3D scaffolds togenerate cartilage-like tissue, but alginate gels havelimitations such as poor mechanical properties. In thisstudy, we fabricated alginate microfibers for humanseptal chondrocyte (HSC) encapsulation and identifiedthe conditions that result in the optimal mechanicalproperties of the alginate microfibers. In vitro experimentsshowed that HSCs encapsulated within alginatemicrofibers maintained ¤90% viability for 7 days,and the 140 μm condition was more effective in termsof HSC proliferation than the 330 and 520 μm conditions. In vivo, HSCs differentiated gradually into cartilagetissue over 4 weeks in immunocompetent mice. Importantly, the alginate-encapsulated HSCs wereisolated and protected from the host immune responsedespite xenograft implantation.