http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Mononeuropathy Multiplex in a Patient with Chronic Active Hepatitis B
남태승,이승한,박만석,최강호,김준태,최성민,김병채,김명규,조기현 대한신경과학회 2010 Journal of Clinical Neurology Vol.6 No.3
Background: Mononeuropathy multiplex is a rare complication during the course of chronic hepatitis B, despite various neuropathies following acute hepatitis B having been reported previously. Case Report: A 30-year-old man presented with sensorimotor symptoms in multiple peripheral nerves. The serological tests for hepatitis were consistent with chronic active hepatitis B. After treatment with oral prednisone combined with an antiviral agent, the sensory and motor symptoms improved and hepatitis B virus replication was reduced. Conclusions: We suggest that chronic immune-mediated neuropathy associated with hepatitis B virus infection should be considered in the differential diagnosis of patients with hepatitis B.
Clinical Characteristics and Analysis of CLCN1 in Patients with “EMG Disease”
남태승,정현정,최석용,김영옥,김명규,조기현 대한신경과학회 2012 Journal of Clinical Neurology Vol.8 No.3
Background and Purpose While the etiology and clinical features of “EMG disease” -which is characterized by diffusely increased insertional activity on needle electromyography (EMG) in the absence of neuromuscular disease - are not well known, some authorities believe it may be a form of myotonia congenita (MC). The aims of this study were to determine the clinical features of EMG disease and its relationship with CLCN1 mutations in patients. Methods The detailed clinical and electrophysiological features of EMG disease were evaluated in six patients. All 23 coding exons and exon-intron boundaries in CLCN1 gene were analyzed by direct sequencing to detect nucleotide changes. Results The common clinical symptoms of EMG disease were chronic muscle stiffness or generalized myalgia, which were aggravated in a cold environment. Four patients complained of action myotonia several times a year. Short trains of provoked positive sharp waves were documented on needle EMG, but myotonic discharges, fibrillation potentials, and fasciculations were not. Increased insertional activity was identified at the asymptomatic muscles studied. One novel heterozygous mutation was identified in one patient following genetic testing for CLCN1 mutations (c.1679T>C, p.Met560Thr). Conclusions The clinical features of EMG disease might be quite similar to those of MC,but CLCN1 mutation was found in only one subject. It is thus difficult to accept that EMG disease lies within the phenotypic spectrum of MC. Additional testing is needed to verify the pathogenetic cause of the diffusely increased insertional activity associated with this condition.
Te Overlap between Fibromyalgia Syndrome and Myotonia Congenita
남태승,최석용,박동진,이신석,김영옥,김명규 대한신경과학회 2015 Journal of Clinical Neurology Vol.11 No.2
Background Fibromyalgia syndrome (FMS) is a complex disorder characterized by chronic widespread pain (CWP), multiple areas of tenderness, sleep disturbance, fatigue, andmood or cognitive dysfunction. Myotonia congenita (MC) is an inherited myopathic disorder that is caused by mutations in the gene encoding the skeletal muscle chloride channel,which can infrequently manifest as generalized muscle cramps or myalgia. Case Report Te frst case was a 33-year-old woman who complained of CWP and chronic headache occurring during pregnancy, and the second case was a 37-year-old man withCWP and depression who sufered from cold-induced muscle cramps. Tese two patientswere initially diagnosed with FMS by rheumatologists, based on CWP of longer than 3months duration and mechanical tenderness in specifc body regions. However, these twoFMS patients were subsequently also diagnosed with MC. Conclusions Tese two cases are the frst report of an overlap of CWP between FMS and MC.
Myasthenia Gravis Aggravated by Steroid-Induced Isolated Mediastinal Tuberculous Lymphadenitis
남태승,박만석,최강호,정현정,윤금진,최성민,김병채,김명규,조기현 대한신경과학회 2010 Journal of Clinical Neurology Vol.6 No.4
Background:Myasthenia gravis (MG) is occasionally aggravated by chronic infection, of which there are many kinds. Case Report:We report herein the case of a 56-year-old woman with MG aggravated by the activation of isolated mediastinal tuberculous lymphadenitis (MTL) during corticosteroid administration. The possibility of MTL had been disregarded in the differential diagnosis of aggravation of MG weakness, because MTL without pulmonary manifestations is uncommon even in areas where tuberculosis is endemic. Conclusions:This case suggests that chronic infections such as tuberculosis should be considered in myasthenic patients with progressive exacerbation if definite evidence for aggravating factors of MG is not obtained.
남태승,정현정,김준태,박만석,김병채,김명규,조기현,최성민,최유덕 대한신경과학회 2009 대한신경과학회지 Vol.27 No.3
Churg-Strauss syndrome (CSS) is a rare systemic vasculitis that is accompanied by asthma and peripheral eosinophilia. We report herein a case of a 32-year-old man with untreated CSS complicated by intracerebral hemorrhage (ICH) in the right basal ganglia. On admission, a hematologic examination revealed eosinophilia and increased perinuclearantineutrophil cytoplasmic antibody levels. A thorough stroke risk-factor evaluation was conducted, but the only risk factor found was CSS. This is the first case of CSS complicated by ICH reported in Korea. Churg-Strauss syndrome (CSS) is a rare systemic vasculitis that is accompanied by asthma and peripheral eosinophilia. We report herein a case of a 32-year-old man with untreated CSS complicated by intracerebral hemorrhage (ICH) in the right basal ganglia. On admission, a hematologic examination revealed eosinophilia and increased perinuclearantineutrophil cytoplasmic antibody levels. A thorough stroke risk-factor evaluation was conducted, but the only risk factor found was CSS. This is the first case of CSS complicated by ICH reported in Korea.
중대뇌동맥 협착에 의한 급성 뇌경색 환자에서 경두개 초음파를 이용한 전대뇌동맥을 통한 측부혈액순환의 평가
남태승,김태학,최성민,이승한,박만석,김병채,김명규,조기현 대한신경과학회 2005 대한신경과학회지 Vol.23 No.2
Background: To investigate the optimal values of transcranial doppler (TCD) index in the evaluation of leptomeningeal collateral circulation (CC) in patients with middle cerebral artery (MCA) stenosis. Methods: Forty-one patients, with angiographically confirmed single stenosis or occlusion of the M1 segment of the MCA, were studied with TCD and brain MRI. Patients were divided into two groups according to the existence of CC though ipsilateral anterior cerebral artery on transfemoral cerebral angiography (TFCA). Mean flow velocities (mFV) of anterior and middle cerebral arteries (ACA, MCA) were analyzed. We then investigated the optimal values of TCD flow index: 1) ipsilateral mFV ACA/MCA (AMVR), 2) ACA velocity ratio (ACAVR), 3) mFVACA. We then correlated TCD flow index with TFCA results. Results: TFCA revealed single moderate to severe M1 stenosis (n=35) and occlusion (n=6). Presence of CC was found in 11 (27%), absence of CC in 30 (73%). The mean of AMVR, ACAVR and mFVACA differed between the two groups: 1.76±0.69, 1.43±36, 86.27±31.73 cm/s in the presence of CC; 0.48±0.24, 1.21±0.39, 65.93±23.24 in the absence of CC. The optimal cutoff values for detection of CC were found at AMVR≥0.9, ACAVR≥1.30 and mFVACA≥80 cm/s. The combination of individual TCD indexes had improved the specificity and positive predicted value in the detection of CC. Conclusions: TCD enables detecting the existence of CC in patients with MCA stenoocclusion. These optimal values may provide a noninvasive method for evaluate the pathomechanism of stroke and prospect the prognosis of these patients.
남태승,박종귀,최성민,이승한,박만석,김병채,김명규,조기현 대한신경과학회 2005 대한신경과학회지 Vol.23 No.2
Background: Behavioral and psychological symptoms (BPS) following acute middle cerebral artery (MCA) infarcts are not uncommon, but these have been considered to be less important than physical disability. The purpose of this study is to evaluate the characteristics of BPS following acute MCA infarcts by using the Korean version of neuropsychiatric inventory (K-NPI). Methods: Fifty-one patients with acute MCA infarcts were studied using the K-NPI scale. We investigated newly developed BPS after the onset of MCA infarcts by interviewing the primary caregiver of each patient. We then evaluated factors related to the BPS such as lesion laterality and various characteristics of the subjects. Results: The most common BPS following acute MCA infarcts was depression. It was present in 69% of the patients, followed by anxiety (61%), agitation (39%), apathy (29%) and irritability (25%). Depression and anxiety were associated with left MCA lesion, whereas apathy was associated with right lesion. Patients with recurrent MCA infarcts more often had depression and anxiety than those without (p=0.03, p=0.04, respectively). Patients with MCA infarcts caused by cardioembolism more often had irritability and disinhibition than those with other subtypes (p=0.01, p=0.02, respectively). Conclusions: BPS is frequently observed following acute MCA infarcts. Therefore, early and adequate assessment of post stroke BPS and appropriate therapy may be important in patients with MCA infarcts.