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삼출성 나이관련황반변성에서 빛간섭단층계와 선택적 초시력 시야계와의 연관성
이승찬,남우호,유승영,곽형우,Seung Chan Lee,Woo Ho Nam,Seung Young Yu Hyung Woo Kwak 대한안과학회 2006 대한안과학회지 Vol.47 No.3
Purpose: Preferential hyperacuity perimeter (PHP) is a device that measures metamorphopsia in the central 14° of the macular visual field which is presented by hyperacuity defect. We elucidated a hyperacuity defect lesion of PHP in exudative age-related macular degeneration (AMD) by Optical coherence tomography (OCT). Methods: Nineteen eyes of 18 patients with exudative AMD diagnosed by fundus examination and fluorescein angiography (FA) underwent PHP. We then elucidated any hyperacuity defect lesion of PHP by fundus photography, FA and OCT. For a control, 20 eyes of 10 age-matched persons who had no ophthalmological abnormality underwent PHP and OCT to determine if hyperacuity defect would appear. Results: Hyperacuity defect lesion appeared in 18 eyes (95%) of AMD patients. There was good locational correlation between the hyperacuity defect lesions and lesions in the fudoscopic examination in 16 eyes of 18, but there was a counterpart relation at the superior-inferior and left-right in 2 eyes. Hyperacuity defect lesion in PHP was of smooth or irregular elevation of the retinal pigment epithelium (RPE) in OCT. In the control, hyperacuity defect lesion appeared in 1 eye (5%) and it was normal in OCT. Conclusions: PHP showed a highly positive rate in detecting AMD-related lesion. The hyperacuity defects that are noted by the PHP are produced from elevation of the RPE.
황혜정,남수경,박현진,박유준,고지원,나희영,곽윤진,김우호,이혜승 대한병리학회 2020 Journal of Pathology and Translational Medicine Vol.54 No.5
Background: Recently, molecular classifications of gastric cancer (GC) have been proposed that include TP53 mutations and their functional activity. We aimed to demonstrate the correlation between p53 immunohistochemistry (IHC) and TP53 mutations as well as their clinicopathological significance in GC. Methods: Deep targeted sequencing was performed using surgical or biopsy specimens from 120 patients with GC. IHC for p53 was performed and interpreted as strong, weak, or negative expression. In 18 cases (15.0%) with discrepant TP53 mutation and p53 IHC results, p53 IHC was repeated. Results: Strong expression of p53 was associated with TP53 missense mutations, negative expression with other types of mutations, and weak expression with wild-type TP53 (p < .001). The sensitivity for each category was 90.9%, 79.0%, and 80.9%, and the specificity was 95.4%, 88.1%, and 92.3%, respectively. The TNM stage at initial diagnosis exhibited a significant correlation with both TP53 mutation type (p = .004) and p53 expression status (p = .029). The Kaplan-Meier survival analysis for 109 stage II and III GC cases showed that patients with TP53 missense mutations had worse overall survival than those in the wild-type and other mutation groups (p = .028). Strong expression of p53 was also associated with worse overall survival in comparison to negative and weak expression (p = .035). Conclusions: Results of IHC of the p53 protein may be used as a simple surrogate marker of TP53 mutations. However, negative expression of p53 and other types of mutations of TP53 should be carefully interpreted because of its lower sensitivity and different prognostic implications.
황반부이상을 나타내는 여러 망막질환에서 선택적초시력시야계 결과분석
김응석,남우호,유승영,곽형우,Eung Suk Kim,Woo Ho Nam Seung Young Yu,Hyung Woo Kwak 대한안과학회 2006 대한안과학회지 Vol.47 No.3
Purpose: The Preferential Hyperacuity Perimeter (PHP) is a device designed to monitor the development of choroidal neovascularization in age-related macular degeneration (AMD) patients. Recent studies have reported the efficacy of the PHP in early detection of AMD. To evaluate hyperacuity, a dot deviation signal is flashed to the central 14 degrees of the macular visual field and the patient`s perceived hyperacuity defect is recorded. The purpose of our study was to identify the role of the PHP in analyzing visual functions of patients with maculopathy caused by retinal diseases other than AMD. Methods: Seventy-four eyes of 55 patients with macular abnormalities caused by various retinal diseases (44 eyes of diabetic retinopathy, 6 eyes of central serous chorioretinopathy, 24 eyes of other retinal diseases) underwent PHP, Optical Coherence Tomography (OCT) and fluorescein angiography (FAG). Results: Of the 74 eyes with maculopathy, 60 eyes (81%) were positive on the PHP. By disease, 40 eyes (40/44, 91%) with diabetic retinopathy, 3 eyes (3/6, 50%) with central serous chorioretinopathy and 17 eyes (17/24, 71%) with other retinal diseases were positive. Among them, the location of hyperacuity defect lesions determined by PHP correlated well with the location shown on OCT and FAG in 6 eyes (6/40, 15%) with diabetic retinopathy, 1 eye (1/3, 33%) with central serous chorioretinopathy and 5 eyes (5/17, 29%) with other retinal diseases. Conclusions: Many retinal diseases that lead to maculopathy revealed a hyperacuity defect on PHP when the lesion was located not only in the retinal pigment epithelium but also in the outer retinal layer. Special attention to the patient`s visual acuity and visual field defects is required when analyzing PHP results since these factors can influence the PHP evaluation.
증식당뇨망막병증에서 유리체절제술 전 베바시주맙 유리체주입술의 유용성
전강석,한재룡,남우호,김하경 대한안과학회 2009 대한안과학회지 Vol.50 No.8
Purpose: To evaluate the efficacy of preoperative intravitreal bevacizumab (AvastinⓇ; Genetech, San Francisco, CA, USA) injections of pars plana vitrectomy (PPV) for proliferative diabetic retinopathy (PDR). Methods: Thirty patients (30 eyes) who underwent PPV for treatment of PDR and received a preoperative intravitreal bevacizumab injection of 1.25 mg were retrospectively analyzed. The study group (group 1, 30 patients, 30 eyes) was compared with a control group (group 2, 29 patients, 30 eyes and matched with the study group for preoperative parameters) who underwent PPV without preoperative intravitreal bevacizumab injection. Results: In both groups, visual acuity improved but there was no statistical significance. Intraoperative vitreous hemorrhage occurred in 14 eyes (46.7%) from group 1 and 11 eyes (36.7%) from group 2. There was no statistical significance of intraoperative bleeding occurrence (p=0.3). Postoperative vitreous hemorrhage occurred in 4 eyes from group 1 and 14 eyes from group 2. The group 1 had a lower incidence of postoperative hemorrhage than group 2 (p=0.005). Conclusions: Preoperative intravitreal bevacizumab injection appears effective in decreasing early postoperative vitreous hemorrhage and maybe technically helpful in PPV for PDR. 목적: 증식당뇨망막병증의 유리체절제술 전 베바시주맙(AvastinⓇ; Genetech, San Francisco, CA, USA) 유리체주입술의 유용성에 대 하여 알아보고자 하였다. 대상과 방법: 증식당뇨망막병증으로 동일한 수술자에 의해서 유리체절제술을 시행 받은 환자를 대상으로 후향적으로 조사하였다. 수술 2일 전 유리체강내 베바시주맙을 주입한 30명 30안을 1군, 주입하지 않은 29명 30안을 2군으로 수술 전후 시력, 수술 중 유리체출혈, 수술 후 유리체출혈 및 합병증 발생 여부를 비교하였다. 결과: 수술 후 두 군 모두 시력은 호전되었으나 두 군 간의 호전 정도의 차이는 없었다(p=0.913). 수술 중 발생한 유리체출혈은 두 군에서 비슷하였다(p=0.3). 수술 후 유리체출혈이 생긴 경우는 1군에서 4안으로, 2군에서 14안으로 1군에서 유의하게 작았다(p=0.005). 결론: 증식당뇨망막병증에서 유리체절제술 전 유리체강내 베바시주맙 주입술은 수술 후 유리체 재출혈을 감소시키는 효과가 있었다. 이는 신생혈관 복합체의 활동력 감소와 섬유화로 섬유혈관증식조직, 견인막 등의 제거에 기술적으로 수술을 더욱 용이하게 하였다.
나이관련황반변성에서 발생한 맥락막신생혈관 환자에서 반복 시행한 광역학치료의 효과
유형곤,강세웅,남우호,고형준,곽형우,권오웅,김시열,김인택,김하경,김현웅,노영정,문준웅,박규형,변석호,송수정,안재균,엄부섭,오재령,유승영,윤일한,이성철,이원기,이재흥,이정희,이지은,이태곤,최광주,함돈일,허걸,정흠 대한안과학회 2007 대한안과학회지 Vol.48 No.6
Purpose: To investigate the effects of repeated photodynamic therapy (PDT) for subfoveal choroidal neovascularization secondary to age-related macular degeneration (AMD) in Korean patients. Methods: Clinical data of patients who were treated with repeated (3 times or more) PDT for subfoveal choroidal neovascularization secondary to AMD and followed up for more than 6 months were collected from 17 hospitals around the country. Visual outcomes at 12 and 24 months, follow-up were compared between subtypes of choroidal neovascularization. The factors related to final visual prognosis and PDT-related adverse effects were evaluated. Results: 244 patients (244 eyes) were recruited (male: 60%, age: 67.7±9.1 years). The portion of patients with predominantly classic, minimally classic, and occult without classic choroidal neovascularization was 57%, 13%, and 24%, respectively and that of patients with visual improvements or less than moderate visual loss at 24 months follow-up were 28%, 38%, 30% and 47%, 56%, and 65%, respectively. Baseline visual acuity and age were significantly related to the final visual prognosis (p<0.05). PDT-related adverse events developed in 15 (6.1%) patients, but most were mild and transient. Conclusions: Repeated PDT for subfoveal choroidal neovascularization secondary to AMD has effects comparable to those of previous prospective, controlled trials without any significant safety concerns in Korea.