악성 부신경절종의 유방 전이: 증례 보고

남상유,한부경 대한영상의학회 2013 대한영상의학회지 Vol.68 No.6

We report a case of metastatic breast cancer from paraganglioma and describe the radiologic findings in a 32-year-old woman who had a history of excision for carotid body paraganglioma. Breast metastasis from malignant paraganglioma showed a well-defined mass with hypoechogenicity, posterior acoustic enhancement and increased vascularity on ultrasonography, and strong enhancements on contrast-enhanced MRI and diffusion restriction on diffusion weighted image. 저자들은 경동맥 소체 부신경절종(carotid body paraganglioma)으로 진단받은 과거력이 있는 32세 여성에서 유방으로 전이된 전이암 1예의 영상 소견을 보고하고자 한다. 초음파에서 경계가 좋은 저에코성 병변으로 후방음향증가와 혈류 증가를 동반하였으며, 조영증강 자기공명영상에서 강한 조영증강을 보이고 확산강조영상에서 확산제한을 보였다.

Breast Imaging Reporting and Data System Category 3 Lesions Detected on Whole-Breast Screening Ultrasound

남상유,고은영,한부경,신정희,고은숙,한수연 한국유방암학회 2016 Journal of breast cancer Vol.19 No.3

Purpose: This study assessed the incidence and cancer rate of probably benign lesions detected on bilateral whole-breast screening ultrasound (US), which corresponded to US Breast Imaging Reporting and Data System (BI-RADS) category 3, and evaluated the proper management of those lesions. Methods: This study was approved by the Institutional Review Board in our institution, which waived informed patient consent. We retrospectively reviewed US images of 1,666 patients who underwent bilateral whole-breast screening US as a supplemental screening test to negative screening mammography or screening US only. The incidence, clinical course, and cancer rate of screening USdetected probably benign lesions corresponding to US BI-RADS category 3 were investigated, and the size and multiplicity of screening US-detected category 3 lesions were evaluated. Results: Probably benign lesions corresponding to US BI-RADS category 3 were detected in 689 of 1,666 patients (41.4%) who underwent screening US. Among them, 653 had follow-up US images for at least 24 months, and among these 653, 190 (29.1%) had multiple bilateral category 3 lesions. Moreover, 539 of 1,666 patients (32.4%) had lesions ≤1 cm in size and 114 of 1,666 (6.8%) had lesions >1 cm (median, 0.82 cm; range, 0.3– 4.2 cm). Four of the 653 patients (0.6%) showed suspicious interval changes and were categorized into BI-RADS category 4. Biopsy analysis confirmed only one lesion as invasive ductal carcinoma at the 6-month follow-up; another lesion was an intraductal papilloma and the remaining two were fibroadenomas. Overall cancer rate of the screening US-detected BI-RADS category 3 lesions was 0.2%. Conclusion: The incidence of category 3 lesions detected on screening US only was very high, but the cancer rate was very low. Therefore, in an average-risk population, routine screening US is preferable over short-term followup for BI-RADS category 3 lesions detected on whole-breast screening US.

MR Spectroscopy and Diffusion Weighted Imaging Findings of Primary Non-Hodgkin Lymphoma of the Breast: Two Case Reports

남상유,유은영,최혜영 대한자기공명의과학회 2014 Investigative Magnetic Resonance Imaging Vol.18 No.2

Primary non-Hodgkin lymphoma (NHL) of the breast is a very rare disease, and the mammographic and ultrasonographicfindings of breast lymphoma are variable. There are several reports of magnetic resonance (MR) imaging findings inpatients with breast lymphomas; however, few reports have described the findings observed on MR spectroscopy or thefeatures of diffusion weighted (DW) imaging. The authors report the findings of classical MR imaging, MR spectroscopyand DW imaging of a 48-year-old woman and a 40-year-old woman with primary non-Hodgkin’s lymphoma of breasts. Mammography and breast ultrasonography revealed a mass with circumscribed margin. The mass showed strongenhancement after contrast injection on MR imaging. DW imaging showed reduced diffusion and high-amplitude choline(Cho) peak at 3.22 ppm was detected by single voxel MR spectroscopy which was consistent with malignancy

유방 과오종의 자기공명영상 소견: 2예 보고

남상유,한부경,이선정,이광희 대한자기공명의과학회 2012 Investigative Magnetic Resonance Imaging Vol.16 No.3

유방의 과오종 (hamartoma)은 다양한 양의 유선조직, 지방 그리고 섬유결체조직으로 이루어진 양성 종양으로 수술로 확인되는 예는 상대적으로 드문 종양이며 자기공명영상에서 확인된 예는 많지 않다. 저자들은 영상에서 진단된 유방암이 있는 여자환자의 반대측 유방에서 우연히 발견된 증례와 만져지는 큰 종괴로 발견되어 수술로 진단된 과오종의 자기공명영상 소견을보고하고자 한다. Breast hamartoma is a relatively rare pathology, composed of various amount of mammary glandular, fatty and fibrous tissue. Here, we report MR findings of two cases of hamartomas; one of them was incidentally found in her left breast during preoperative MRI in a woman with right breast cancer, and the other was presented as a large palpable mass. Both of them were confirmed by surgical excision. Breast hamartoma shows a well-defined mass with mixed signal intensity on T2-weighted image MRI and a little or focal enhancement on contrastenhanced MRI.

Role of BRAFV600E Mutation Analysis for Thyroid Nodules Classified as Indeterminate on Ultrasonography

남상유,신정희,한부경,고은영,강석선,한수연,황지영,남미영,김종원,정재훈 대한초음파의학회 2010 ULTRASONOGRAPHY Vol.29 No.1

Purpose: We aimed to evaluate a possible role for BRAFV600E mutation analysis of aspiration specimens in the work up of thyroid nodules classified as indeterminate on US. Materials and Methods: A total of 122 nodules from 122 patients were prospectively classified as indeterminate nodules based on US findings. US-guided fine needle aspiration (FNA) was done for all 122 nodules. The presence of a BRAFV600E mutation in FNA specimens was determined by allele-specific PCR. Results: US-indeterminate nodules were confirmed as malignant in 20.5% (25/122)of cases and benign in 76.2% (93/122) after FNA or surgery. A few (3.3% (4/122),remained indeterminate. A BRAFV600E mutation was identified in 14.8% (18/122) of USindeterminate nodules. Of those 18 nodules, three were benign and 13 were malignant after the initial FNA. One (0.8%, 1/122) with an initially benign cytology and a BRAFV600E mutation was confirmed to be malignant after surgery. The remaining two benign nodules with a mutation were not followed-up. All 9 initial FNA-nondiagnostic nodules were mutation negative but 2 (11.8%) of 17 indeterminate nodules on initial FNAs were mutation positive. Conclusion: BRAFV600E mutation analysis prevents false negative cytology for only 0.8% of cases and reduces ambiguous diagnoses for 1.6% of all US-indeterminate thyroid nodules. Therefore, adding BRAFV600E mutation analysis to FNA for US-indeterminate nodules is of limited usefulness.

중학생을 위한 인공지능 교육내용 설계 및 분석

남상유,박승보 한국인공지능교육학회 2022 인공지능연구 논문지 Vol.3 No.1

Cystic Hypersecretory Carcinoma of the Breast: Sonographic Features with a Histological Correlation

남상유,한부경,신정희,조은윤,고은영 대한영상의학회 2010 대한영상의학회지 Vol.62 No.3

Purpose: To evaluate imaging findings of cystic hypersecretory carcinoma (CHC) of the breast, with an emphasis of the sonographic (US) features, and to correlate the US findings with the histology. Materials and Methods: During the last 13 years, six women with a mean age of 43 years were histologically confirmed with CHC of the breast. We retrospectively reviewed the clinical records, US images, and correlated them with histological findings. Results: US showed a large complex cystic mass lined by a thin wall (n = 2), multiple small cysts in focally heterogeneous background parenchyma without predominant mass (n = 3), and an irregular mass with an ill-defined margin and ductectasia (n = 1). The pathology revealed that the thin walls of the cysts were all cystic hypersecretory intraductal carcinomas, while the solid portions of the lesions varied from benign intraductal papillomas to minimal infiltrating ductal carcinoma in the background of the cystic hypersecretory intraductal carcinomas. Conclusion: The characteristic US findings of cystic hypersecretory carcinoma are either a large complex cystic and solid mass or multiple small cysts in the background of a focally heterogeneous parenchyma.

A comparison of lymphocytic thyroiditis with papillary thyroid carcinoma showing suspicious ultrasonographic findings in a background of heterogeneous parenchyma

남상유,신정희,고은영,한수연 대한초음파의학회 2015 ULTRASONOGRAPHY Vol.34 No.1

Purpose: The aim of this study was to compare ultrasonographic features in patients with lymphocytic thyroiditis (LT) and papillary thyroid carcinoma (PTC) having suspicious thyroidnodule(s) in a background of heterogeneous parenchyma and to determine the clinical and radiological predictors of malignancy. Methods: We reviewed the cases of 100 patients who underwent ultrasonography between April 2011 and October 2012, and showed suspicious thyroid nodule(s) in a background ofheterogeneous parenchyma. Eight patients who did not undergo ultrasonography-guided fineneedle aspiration cytology (FNAC) and 34 cases of follow-up ultrasonography after initial FNACwere excluded. We compared the benign and malignant nodules in terms of their clinical and radiological factors. Results: For the 58 nodules including 31 LTs (53.4%) and 27 PTCs (46.6%), the mean tumor sizes of the two groups were 0.96 cm for LT and 0.97 cm for PTC. A univariate analysis revealedthat PTCs were more frequent in patients younger than 45 years and having microcalcifications than was LT. An independent predictor of PTC after adjustment was an age of <45 years. Conclusion: LT mimics malignancy in a background of heterogeneous parenchyma on ultrasonography. A young age of <45 years is the most important predictor of malignancy in thiscondition.

해외저술 소개 : 임상 연구: 치료 ; 횡격막과 닿아 있는 간종양의 경피적 고주파열 치료: 인공 복수의 열감소 효과(heat-sink effect)의 임상적 평가(초)

남상유 ( S. Y. Nam ),임현철 ( H. Rhim ),강태욱 ( T. W. Kang ),이민우 ( M. W. Lee ),김영선 ( Y. S. Kim ),최동일 ( D. Choi ),이원재 ( W. J. Lee ),박율리 ( Y. Park ),장일수 ( I. Chang ),임효근 ( H. K. Lim ) 대한간암연구회 2010 대한간암학회지 Vol.10 No.-

Invasive Lobular Carcinoma: MRI Features and Clinicohistological Characteristics According to the ER, PR, and HER Statuses

유은영,남상유,최혜영,조현이 대한자기공명의과학회 2015 Investigative Magnetic Resonance Imaging Vol.19 No.3

Purpose: To investigate correlations of estrogen receptor (ER), progesterone receptor(PR), and human epidermal growth factor receptor type 2 (HER2) statuses withmagnetic resonance imaging (MRI) features and clinicohistological characteristics inpatients with invasive lobular carcinoma (ILC). Materials and Methods: Data from 64 histologically confirmed ILCs were analyzedretrospectively. Preoperative breast MRI was reviewed for morphology and dynamiccontrast-enhanced kinetics of the tumor. Pathologic reports were reviewed for ER,PR, and HER2 positivity, tumor size, lymph node metastasis, and the number ofmetastatic lymph nodes. Furthermore, there was an investigation of the MRI featuresand clinicohistologic characteristics, according to the ER, PR, and HER2 statuses. Results: A significant difference in MRI features and clinicohistological tumorcharacteristics were observed only in relation to PR status. Of the 64 ILCs, 10 (15.6%)were PR negative. PR negative cancers, compared with PR positive cancers, weremore likely to present as non-mass enhancement (P = 0.027); have a significantlylarger mean tumor size (5.00 ± 1.05 cm vs. 2.57 ± 0.21 cm, P = 0.021); and havesignificantly more metastatic lymph nodes (P = 0.010). Conclusion: PR negative ILC presented more frequently as non-mass enhancementon MRI, with larger tumors and increased numbers of metastatic lymph nodes. Therefore, the PR status plays an important role in determining MRI features andclinicohistological characteristics of ILC.