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      • NIDDM 환자에서 경구당부하검사와 공복시 혈청 유리 지방산 농도와의 상관관계

        남경제,임경호 인제대학교 1999 仁濟醫學 Vol.20 No.2

        Background: NIDDM may have more to do with abnormalities in fat than carbohydrate metabolism. One possible mechanism would be elevation of free fatty acids. This study was conducted to evaluate the correlation between insulin secretory pattern in oral glucose tolerance test and serum free fatty acid concentrations in NIDDM patients. Methods: We performed 75 g oral GTT in 310 NIDDM patients. During oral GTT, we measured serum glucose, insulin, c-peptide, lipid concentrations (total cholesterol, triglycerride, HDL-cholesterol, Lp(a), free fatty acid) Results: 1) There was significant correlation between serum FFA concentrations and body mass index, serum total cholesterol concentrations and triglyceride concentrations. But we cannot find correlation between serum FFA concentrations and ages of patients, duration of disease, HbA1c, serum HDL-cholesterol concentrations and serum Lp(a) concentrations. 2) There was significant correlation between serum FFA concentrations and serum glucose levels on fasting, 30min, 60min. But there was no correlation between serum FFA concentrations and serum insulin concentrations and c-peptide concentrations. 3) There was significant correlation between serum FFA concentrations and serum glucose response area. But there was no correlation between serum FFA concentrations and insulin response area and C -peptide response area. 4) There was no correlation between serum FFA concentrations and fasting glucose/insulin ratio and glucose/C-peptide ratio. Conclusion: These results suggest that there was inadequate interrelation between serum FFA concentrations and parameters of insulin sensitivity derived from oral glucose tolerance test of NIDDM patients.

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