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      • 초고속 정보통신망을 통한 3차원 영상 정보의 가상현실 관리에 관한 연구

        진호(Kim Jin Ho),지인(Kim Jee In),장천(Chang Chun Hyon),송상훈(Song Sang Hoon) 한국정보처리학회 1998 정보처리학회논문지 Vol.5 No.12

        In this paper, we describe a Medical Image Information System. Our system stores and manages 3 dimensional medical image data and provides the 3 dimensional medical data via the Internet. The Internet standard VR format, VRML(Virtual Reality Modeling Language) is used to represent the 3D medical image data. The 3D images are reconstructed from medical image data which are generated by medical imaging systems such as CT(Computerized Tomography), MRI(Magnetic Resonance Imaging), PET(Position Emission Tomography), SPECT(Single Photon Emission Computed Tomography). We implemented the medical image information system which uses a surface-based rendering method for the reconstruction of 3D images from 2D medical image data. In order to reduce the size of image files to be transferred via the Internet. The system can reduce more than 50% for the triangles which represent the surfaces of the generated 3D medical images. When we compress the 3D image file, the size of the file can be reduced more than 80%. The users can promptly retrieve 3D medical image data through the Internet and view the 3D medical images without a graphical acceleration card, because the images are represented in VRML. The image data are generated by various types of medical imaging systems such as CT, MRI, PET and SPECT. Our system can display those different types of medical images in the 2D and the 3D formats. The patient information and the diagnostic information are also provided by the system. The system can be used to implement the "Tele-medicine" systems.

      • KCI등재

        의과대학 강의실의 좌석 선호도와 학업성취도 관계 분석

        유효,박지해,정수,형태,영전,동찬 한국의학교육학회 2012 Korean journal of medical education Vol.24 No.2

        Purpose: This study aimed to explore the relationship between students' seating preferences and academic achievement in medical school. Methods: The subjects of this study were 109 second-year students in C medical school. The pattern of seat selection of 109 students was surveyed by participant observation for 48 days, and a questionnaire was administered to determine the factors that were considered by students. Using SPSS version 12.0, we analyzed the factors that students considered with regard to seat selection and seat preference and the frequency of seat movements between areas. We performed one-way ANOVA to analyze the differences in academic achievement between students who moved seats versus those who did not. Results: The most common reasons for seat selection were to focus better on the lecture (60 students), to focus better on lecture, and to feel familiar with the same seat (60 students). Students' preferred seats were in rows A4, A7, A5, and A3 (in descending order), which are primarily the central sections, and columns B15, B1, B14, B19 (in descending order), which are primarily both ends of the division. The difference in academic achievement between students who moved seats and those who did not was not significant (p>0.05). Among students who did not move seats, the difference in academic achievement between 9 seating areas was not significant in 6 subjects (p>0.05). Conclusion: The results of this study suggest that we should reconsider a professor's general perception regarding academic achievement according to seat location.

      • KCI등재

        산수유 추출물에 의한 testosterone으로 유발된 양성 전립선 비대증의 개선

        선영,민영,황보,이혜숙,홍수,태희,윤선혜,현진,정하은,성연,태중,,성옥,최영,Ji, Seon Yeong,Kim, Min Yeong,Hwangbo, Hyun,Lee, Hyesook,Hong, Su Hyun,Kim, Tae Hee,Yoon, Seonhye,Kim, Hyun Jin,Jung, Ha Eun,Kim, Sung Yeon,Kim, 한국생명과학회 2021 생명과학회지 Vol.31 No.6

        양성 전립선 비대증(BPH)의 발병은 노화에 따른 남성 호르몬 수치의 변화와 연관된 내분비 기능 저하와 밀접한 관련이 있는 것으로 알려져 있다. 현재 BPH 치료를 위해 임상적으로 사용되는 약물은 다양한 부작용을 나타내므로 효과적인 대체 식의약 소재의 개발을 시급히 요구된다. 산수유나무의 열매인 산수유(Fructus Corni)는 오랫동안 다양한 질병의 예방 및 치료에 사용되어왔으며 최근 BPH의 진행을 억제할 수 있음이 밝혀졌다. 본 연구에서는 BPH에 대한 산수유 열수 추출물(CF)의 추가 효능을 평가하기 위해 비거세 및 거세 동물 모델에서 TP에 의한 BPH 유도에 미치는 효과를 조사하였으며, BPH 억제를 위한 양성대조군으로 FINA를 사용하였다. 본 연구의 결과에 의하면 CF 투여는 대조군 및 FINA 처리 그룹에 비하여 비거세 및 거세군 모두에서 전립선의 과도한 발달을 억제하였다. BPH에 대한 CF의 억제 효과는 BPH 유도에 관여하는 testosterone과 DHT의 발현 감소뿐만 아니라 HIF-1α, 5α-reductase type 2, SRC1, AR 및 PSA 발현의 과도한 발현 억제와 관련이 있었다. 또한, 스트레스 호르몬인 cortisol의 혈청 수준은 비거세 및 거세군 모두에서 TP에 의한 BPH 유도 동안 증가하였지만 CF 투여에 의하여 유의하게 감소되었다. 그러나 BPH 유도군에서 insulin 및 IGF-1은 증가되지 않았으며 CF에 의한 효과적인 결과는 나타나지 않았다. 이러한 결과는 AR 신호 전달 경로 활성의 억제를 통해 BPH에 대한 CF의 유익한 효과를 시사하며, 산수유가 BPH의 예방과 치료에 잠재적인 가능성을 가지고 있음을 시사한다. Fructus Corni, the fruit of Cornus officinalis, has long been used for the prevention and treatment of various diseases. We recently suggested that it was effective against benign prostatic hyperplasia (BPH). In this study, we investigated the inhibitory effect of Corni Fructus (CF) water extract on BPH induced by testosterone propionate (TP) in noncastrated and castrated animal models. BPH was induced in Sprague Dawley rats by an intramuscular injection of TP in castrated or noncastrated rats. Finasteride (FINA) treatment was used as a positive control for inhibition of BPH. According to our results, CF administration inhibited excessive enlargement of development of the prostate in both the noncastrated and castrated groups compared to the control and FINA-treated groups. The inhibitory effect of CF on BPH was associated with inhibition of expression of hypoxia-inducible factor-1α, 5α-reductase type 2, steroid receptor coactivator-1, androgen receptor (AR), and prostate-specific antigen. Serum levels of the stress hormone cortisol increased during BPH induction by TP in both the noncastrated and castrated groups, but they were attenuated significantly by CF administration. However, insulin and IGF-1 levels were not increased in the BPH-induced groups and CF, and no effective results were found by CF administration. These results point to a beneficial effect of CF on BPH through inhibition of AR signaling pathway activity and imply that CF shows excellent potential as a therapeutic agent for the prevention and treatment of BPH.

      • KCI등재

        산수유의 채취 부위에 따른 기능 성분 분석과 항산화 및 항염증 효과에 관한 연구

        황보(Hyun Hwangbo),정지숙(Ji-Suk Jeung),민영(Min Young Kim),선영(Seon Yeong Ji),윤선혜(Seonhye Yoon),태희(Tae Hee Kim),성옥(Sung Ok Kim),최영(Yung Hyun Choi) 한국생명과학회 2021 생명과학회지 Vol.31 No.3

        산수유 나무는 그 열매인 산수유와 함께 동아시아의 많은 국가에서 식용 및 약용으로 오랫동안 널리 사용되고 있다. 선행 연구들에 의하면 산수유 나무 추출물 및 구성 성분은 다양한 약리학적 잠재력을 가지고 있음에도 불구하고 부위별 추출물에 대한 체계적인 성분 분석은 아직 충분하지 않은 실정이다. 본 연구에서는 산수유 나무의 각 부위(청산수유, 적산수유, 씨앗, 줄기, 잎, 건피)의 유효 성분 함량을 분석하여 항산화 활성을 검증하였다. 본 연구의 결과에 따르면 조사된 3가지 지표 성분 중 morroniside은 청산수유와 적산수유에 가장 많이 함유하고 있었으며, loganin은 청산수유와 씨앗에 많았다. 잎, 적산수유, 건피의 함량은 비슷한 수준이었다. Cornin은 잎에 가장 많았으며, 청산수유, 적산수유 건피 순이었다. 또한 총 폴리페놀 함량은 적산수유, 청산수유, 잎 순으로 높았으며, 총 플라보노이드 함량은 잎이 가장 높았다. 그리고, DPPH radical 소거능은 잎, 씨앗, 적산수유 추출물 순으로 높은 소거 활성을 나타냈다. 따라서 항산화 활성이 가장 높은 잎 추출물의 항염증 효능을 조사하였으며, 이를 위하여 LPS로 자극된 RAW 264.7 대식세포에서 NO와 같은 염증성 매개 인자와 IL-1β와 IL-6를 포함한 염증성 사이토카인의 생성에 미치는 잎 추출물의 영향을 평가하였다. 본 연구의 결과에 의하면 세포독성이 없는 조건에서 잎 추출물은 LPS에 의하여 증가된 iNOS의 발현과 NO의 생성을 유의적으로 억제하였다. 또한 잎 추출물은 LPS에 의한 IL-1β 및 IL-6의 생성 및 발현을 현저하게 감소시켰다. 따라서 산수유 나무의 잎 추출물은 항산화제와 항염증 제의 개발을 위한 천연 재료로서 잠재력이 있음을 시사하며, 관련 기전 연구가 추가로 진행되어야 할 것이다. Cornus officinalis Siebold & Zucc. is traditionally used as an edible and medicinal plant in many countries in East Asia. Previous studies have shown the pharmacological potential of extracts and components of C. officinalis, but comparative analysis of the composition of the leaf, stem, and fruit extracts has been insufficient to date. In the present study, the content of active antioxidant and anti-inflammatory ingredients was verified in different C. officinalis parts (under-ripe sansuyu, ripe sansuyu, seed, leaf, stem, and dried sansuyu). One active component, morroniside, was high in fruit (under-ripe and ripe sansuyu), while loganin was high in fruit (under-ripe sansuyu) and cornin was high in seeds. Total polyphenol contents were highest in fruit (ripe sansuyu) and flavonoids were highest in leaves. DPPH radical scavenging activity was highest in leaves, followed by seeds and then ripe sansuyu extract. The anti-inflammatory efficacy of leaf extracts of C. officinalis (LCO) was further investigated by measuring their effects on levels of nitric oxide (NO) and the pro-inflammatory cytokines interleukin (IL)-1β and IL-6 in RAW 264.7 macrophages. Non-cytotoxic concentrations of LCO effectively decreased the lipopolysaccharide (LPS)-induced expression of inducible NO synthase, resulting in decreased NO production. LCO also significantly suppressed LPS-induced production and expression of IL-1β and IL-6. Taken together, the present findings suggest that C. officinalis leaves have potential as natural materials for the development of antioxidant and anti-inflammatory agents.

      • KCI등재

        지역주민의 지역사회참여에 미치는 영향요인에 관한 실증연구: 글로벌새마을정신과 공동체의식 그리고 세계시민의식을 중심으로

        지인,이호 충북대학교 국제개발연구소 2018 사회적경제와 정책연구 Vol.8 No.1

        Community participation is a crucial factor that contributes to individual's wellbeing and social development. Government, international organizations, academia and other stakeholders have emphasized community member's participation in development context. Community member's engagement and participation in community activities has increased throughout the past years in Korea. However, local people's participation is still an ongoing issue that should be prompted and emphasized for present and future development, as civic engagement has recorded the least important topic among 11 well-being topics in Korea according to OECD Better Life Index. In this perspective, this research was conducted to verify its effects and relationship between community participation and its independent variables set. As a result, the core values of Global Saemaul Undong has an impact on community participation, and sense of community and global citizenship has a mediating effect in the relationship between the core values of Global Saemaul Undong and community participation. 본 연구는 대학생을 대상으로 지역주민의 지역사회참여에 미치는 영향을 검증하는 데 그 목적이 있으며, 글로벌새마을정신, 공동체의식, 세계시민의식을 중심으로 지역사회참여에 미치는 영향을 분석하고자 구조방정식모형과 매개효과분석을 실시하였다. 분석결과, 글로벌새마을정신은 지역사회참여에 유의한 정(+)의 영향을 미치는 것으로 나타났으며, 공동체의식과 세계시민의식은 글로벌새마을정신과 지역사회참여 간의 관계에서 매개효과를 가지는 것으로 나타났다. 본 연구의 결과는 사회심리학적 관점에서 지역사회참여 증진 방안을 살펴본 데 의의를 가지며 지역사회참여 제고에 중요한 자료로 활용될 것으로 기대한다.

      • KCI등재
      • KCI등재

        2011 Clinical Practice Guidelines for Type 2 Diabetes in Korea

        고승,성래,동준,오승준,이혜진,심강희,우미혜,준영,난희,재택,종화,혜진,정인경,홍은경,조재형,목지오,윤건호 대한당뇨병학회 2011 Diabetes and Metabolism Journal Vol.35 No.5

        As in other countries, type 2 diabetes is major health concern in Korea. A dramatic increase in the prevalence of type 2 diabetes and its chronic complications has led to an increase in health costs and economic burdens. Early detection of high risk individuals,hidden diabetic patients, and improvement in the quality of care for the disease are the first steps to mitigate the increase in prevalence. The Committee of Clinical Practice Guidelines of the Korean Diabetes Association revised and updated the ‘3rd Clinical Practice Guidelines’ at the end of 2010. In the guidelines, the committee recommended active screening of high risk individuals for early detection and added the hemoglobin A1c level to the diagnostic criteria for type 2 diabetes based on clinical studies performed in Korea. Furthermore, the committee members emphasized that integrating patient education and self-management is an essential part of care. The drug treatment algorithm based on the degree of hyperglycemia and patient characteristics were also updated.

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