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전이성 신세포암의 보조 면역치료로써 자가종양백신의 적용
박동수,오도연,강명서,안희정,이선주,김남근 대한비뇨의학회 2005 Investigative and Clinical Urology Vol.46 No.10
About 50% of renal cell carcinoma patients initially present with a regional or distant metastatic disease. Attempts to treat metastatic renal cell carcinomas have been directed at cytokine-based immunotherapy. Response rates of interleukin-2-based immunotherapy of 5 to 29% have been reported in this disease. Immunization as a mechanism to recruit host antitumor responses is increasingly being described as a potentially effective and less toxic approach for the treatment of metastatic and high-risk primary cancers. An autologous renal cell cancer vaccine has been applied at our institution for the prevention of recurrence or metastasis in locally advanced cases for more than one year. Herein, two metastatic renal cell carcinoma cases, which failed to show a response to initial immunotherapy or chemoradiotherapy, which were successfully treated with IL-2(Aldesleukin) and interferon-alpha as autologous cancer vaccine adjuvants is reported.
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디지털 전환 기술이 조직행동에 미치는 영향: 업무자율성 및 혁신행동의 이중매개효과
김 연 수,허찬영 사회혁신기업연구원 2023 혁신기업연구 Vol.8 No.4
This study investigates the influence of digital transformation technologies on organizational behavior within public institutions. To empirically validate the findings, the study examined: the relationships between technological factors of digital transformation and sub-factors of organizational behavior; the relationships between technological factors of digital transformation, work autonomy, and innovative behavior; and whether work autonomy and innovative behavior act as dual mediators in these relationships. The independent variables were selected as the technological aspects of digital transformation, specifically focusing on data availability, data quality, scalability of data utilization, and system usability as measured by cloud transition technology. Meanwhile, the dependent variables were identified as key factors of organizational behavior, which include Education-Training, leadership, and organizational culture. The mediators were chosen as work autonomy and innovative behavior, with the relationships between these variables studied based on both domestic and international prior research. Firstly, the results for Research Hypothesis 1 showed that higher levels of digital transformation technologies within an organization were positively perceived in relation to sub-factors of organizational behavior. Secondly, Research Hypothesis 2 found that work autonomy served as a mediator between digital transformation technology and organizational behavior. Thirdly, Research Hypothesis 3 found that innovative behavior only partially mediated the relationship between digital transformation technology, leadership, and organizational culture. Lastly, Research Hypothesis 4 revealed that work autonomy and innovative behavior exhibited dual mediating effects only in the relationship between digital transformation technology and leadership. In conclusion, the adoption of digital transformation technologies within public institutions elevates work autonomy and stimulates innovative behavior, thereby strengthening leadership. The interplay between these variables contributes to changes in organizational behavior and roles from various aspects, ultimately benefiting organizational performance. Thus, there is a need for policy initiatives to support the development of digital and innovative capabilities within public organizations and to create more flexible working environments.
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