조사 (어문론총 제 6 집 , 김희윤)

김희윤 경북어문학회 1971 어문론총 Vol.6 No.1

Prescription Patterns for Patients with Schizophrenia in Korea: A Focus on Antipsychotic Polypharmacy

김희윤,김철응,배재남,이희원,정승호,이정섭,강민희 대한정신약물학회 2014 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.12 No.2

Objective: This study investigated the prescription patterns for Korean patients with schizophrenia with a particular focus onantipsychotic polypharmacy. All data were gathered from patients presenting at 41 tertiary university hospitals and 8 secondaryhospitals. Methods: Data from three multicenter studies conducted in Korea were retrospectively reviewed and integrated to identify patientswith schizophrenia who had their antipsychotic medication switched to paliperidone extended-release between 2008 and 2009. The rates for antipsychotic polypharmacy, combined use of different antipsychotic classes with a special focus on atypical antipsychotics,and psychotropic polypharmacy using benzodiazepines, mood stabilizers, and other relevant drugs were identified. Results: Of the 851 Korean patients analyzed in this study, 20.4% (n=173) had been prescribed antipsychotic polypharmacy. Of the 678 patients receiving antipsychotic monotherapy, 6.9% (n=47) were prescribed a typical antipsychotic and 93.1% (n=631)were prescribed an atypical antipsychotic. Of the 173 patients receiving a combination of antipsychotic drugs, only 6.4% (n=11)had been prescribed polypharmacy with typical antipsychotics, while 46.82% (n=81) were prescribed atypical+atypical antipsychoticsor typical+atypical antipsychotics. The highest co-prescription rates for other psychotropic drugs in conjunction withantipsychotics included benzodiazepines (30.3%), anticholinergic drugs (28.8%), antidepressants (13.3%), β-blockers (10.1%),and mood stabilizers (8.7%). Conclusion: The present findings demonstrate that the rate of antipsychotic polypharmacy is relatively low in Korea and thatKorean clinicians prefer to prescribe atypical, rather than typical, antipsychotic drugs. This suggests that there is a distinctprescription pattern in Korea that is focused on antipsychotic polypharmacy.

페놀 유출 사례

김희윤,서병성,김수근,박환진,김정호,손희승,손유일 대한직업환경의학회 2014 대한직업환경의학회 학술대회 논문집 Vol.2014 No.11

Montelukast delayed the gestational period in the LPS-induced preterm mouse model

김희윤,홍순철,이아영,안기훈 한국모자보건학회 2017 한국모자보건학회 학술대회 연제집 Vol.2017 No.2

Objective Montelukast is known as a cysteinyl leukotriene 1 receptor antagonist. However, the action of montelukast in preterm is unknown. We aimed to demonstrate the potential anti-inflammatory effect of montelukast. Methods All animal experiments were approved by the Committee for Care and Use of Laboratory Animal at Korea University. We used sexually mature female ICR mice. Gestational period was calculated by setting "mucus plug detection day" to day 1. The group was divided into three groups of control, lipopolysaccharide(LPS), and LPS plus Montelukast(MK). On day 16 of gestation ICR mice received lipopolysaccharide (LPS) intrauterine (100 ㎍)or Normal saline (100 μl) via laparotomy at right uterine between first and second fetus. The Montelukast group was orally administered 20mg/kg/day after LPS injection. The uterine cervix was collected immediately after delivery. The results were statistically analyzed by SPSS software. Results Mean duration of pregnancy from the injection to parturation were 91, 44.5, and 73 hours in control, lipopolysaccharide(LPS) injection, and LPS injection plus Montelukast group, respectively, LPS injection group showed a significant lower pregnancy period compared with control. Montelukst, however, showed delay in preterm delivery. Fetus born by preterm birth showed lower height and weight than control group. Fetal mortality was 0% in control group, whereas 55% in LPS and LPS plus MK group. Conclusion Our results show the effect of Montelukast when preterm birth occurs after LPS injection. Montelukast delay the duration of pregnancy in LPS-induced preterm birth, but does not significantly affect fetal mortality.

압력 수분 처리(Pressure Moisture Treatment, PMT)를 사용하여 제조한 물리적 변성 녹말의 물리화학적 특성 연구

김희윤,박진호,최성원,허남윤,김창남,김병용,백무열 한국산업식품공학회 2019 학술대회 및 심포지엄 Vol.2019 No.04

임산부 유해물질 취급 사업장의 임산부 산업보건관리 실태조사

김희윤,김수근,김원술,박소영,서병성,손유일,손희승,정한슬 대한직업환경의학회 2015 대한직업환경의학회 학술대회 논문집 Vol.2015 No.11

복합생균제의 첨가급여가 비육돈의 생산성과 육질특성에 미치는 영향

김희윤,김영직,박구부,Kim, Hee-Yoon,Kim, Young-Jik,Park, Gu-Boo 한국축산식품학회 2007 한국축산식품학회지 Vol.27 No.1

본 시험은 비육돈에 대한 복합 생균제의 사료적 가치를 평가하기 위하여 시판 생균제를(0, 0.2, 0.5 및 1.0%) 삼원 교잡종($Landrace{\times}Yorkshire{\times}Duroc$, 평균체중 $55.3{\pm}1.5 kg$) 비육돈 48두를 공시하여 58일간 급여하여 증체량, 사료섭취량, 도체등급과 도체율, 육의 pH, 육색, 지방색 및 지방산 함량을 분석하였다. 일당 증체량은 0.2%구가 0.95 kg으로서 대조구(0.85 kg)에 비하여 증가(p<0.05)하였으며, 일당 사료섭취량은 대조구를 포함한 모든 처리구에서 2.79-2.84 kg로서 차이는 없었다. 사료요구율은 0.2%구가 2.96으로서 대조구(3.28)에 비하여 개선효과(p<0.05)가 뚜렷하였다. 도체중량과 도체율 및 등지방 두께는 대조구를 포함한 모든 처리구에서 차이는 없었으며 A등급 출현율은 0.2%구가 46.67%로서 타구에 비하여 향상되었다. 육의 수분, 조단백질 및 조회분 함량은 대조구를 포함한 모든 처리구에서 차이는 없었지만 조지방 함량은 0.2%구가 다른 처리구에 비하여 낮은 경향이었다. 육의 pH는 대조구를 포함한 모든 처리구에서 차이는 없었다. 생균제를 첨가함으로서 육색의 명도($L^*$)값은 낮았으며, 적색도($a^*$) 값은 높게 나타났다. 포화지방산 함량은 0.2%구와 0.5%구에서 낮았으며, 불포화지방산 함량은 생균제를 급여한 모든 처리구에서 높게 나타났다(p<0.05). This study was conducted to determine the effects of dietary supplementation with probiotics on the growth and meat quality of finishing pigs. A total of forty eight ($Landrace{\times}Yorkshire{\times}Duroc$) pigs ($55.3{\pm}1.5 kg$ average initial body weight) were randomly assigned to four groups and fed on a diet supplemented with 0, 0.2, 0.5 or 1% probiotics for 58 days. The pigs were slaughtered at approximately 105 kg live weight. Supplementation with 0.2% probiotics significantly (p<0.05) increased daily gain compared to the control. The daily gain of pigs in the 0.2% probiotic group was 0.95 kg whereas that of the control was 0.85 kg. The average feed intake was 2.79-2.84 kg and there were no significant differences in feed intake between the control and test groups. The feed conversion of the 0.2% probiotic group was 2.96 kg whereas the control showed a feed conversion of 3.28 kg. The results of this study imply that supplementation with 0.2% probiotics may improve the feed conversion of pigs. There were significant differences in carcass weight, carcass ratio, backfat thickness, and frequency percentage of A grade carcasses between the control and probiotic test groups. In addition, the moisture, crude protein and crude ash contents of the probiotic treated groups did not differ significantly from the control group, however the crude fat values of the 0.2% probiotic test group was significantly tower than the other groups. The muscle pH levels of all samples ranged from 5.63-5.67 which is the normal pH of pork. The supplementation of probiotics resulted in decreased lightness ($L^*$) values and increased redness ($a^*$) values. Furthermore, the saturated fatty acid contents of the 0.2% and 0.5% probiotic test groups decreased and the unsaturated fatty acid contents increased relative to the control.

디지털홈 산업동향 및 구축방안

김희윤 한국정보통신기술협회 2003 TTA저널 Vol.88 No.-

Pressure moisture treatment and hydro-thermal treatment of starch

김희윤,백무열 한국식품과학회 2022 Food Science and Biotechnology Vol.31 No.3

Starch is often subjected to denaturation treat- ment to improve its useful properties and eliminate its shortcomings. Various methods have been developed to produce modified starches with different properties and for a variety of uses. Because physically modified starch can be produced without chemical substances or biological agents, the modification method is very simple and inex- pensive, and the resulting material can be used as clean label starch. Among these physical modification tech- nologies, heat moisture treatment (HMT) is a universally valid technology, but little is known about pressure mois- ture treatment (PMT)-related technology. Physical modi- fication of starch using PMT results in new functions and value-added characteristics required by industry, and PMT has the potential to produce starch with new functions. In this paper, PMT-related technologies for physically modi- fied starch, the difference between PMT and the hydro- thermal treatment, and clean label starch manufacturing using HMT and PMT were investigated.

생균제, Illite, 활성탄 및 목초액의 첨가가 육성-비육돈의 육질 특성에 미치는 영향

김희윤,김영직,Kim, Hee-Yoon,Kim, Young-Yik 한국축산식품학회 2007 한국축산식품학회지 Vol.27 No.1

We investigated the effects of dietary supplements such as probiotics, illite, active carbon and hardwood vinegar on growth performance and meat quality characteristics in finishing pigs. One hundred fifty pigs ($Landrace{\times}Yorkshire{\times}Duroc$; $32.3{\pm}1.3 kg$ average initial body weight) were used for a 100 day experiment. Pigs were randomly placed into one of five experimented diet groups (control, 0.2% probiotics, 1.0% illite, 1.0% active carbon, and 1.0% hardwood vinegar) and were slaughtered at approximately 110 kg live weight. The addition of 1.0% active carbon and hardwood vinegar caused a decrease in free water while, WHC (water holding capacity) was higher compared with controls. Drip loss in hog flesh was decreased by feeding probiotics, illite, active carbon and hardwood vinegar. Cooking loss was decreased when hogs were fed hardwood vinegar. Lightness ($L^*$) and redness ($a^*$) were no difference between the all treatment groups, yellowness ($b^*$) was higher when feeding active carbon and hardwood vinegar by 1.0%. When hogs were fed hardwood vinegar, drip loss was decreased, and meat color was higher in sensory evaluation of fresh meat. In cooked hog meat, meat color and juiciness were higher in hogs fed hardwood vinegar. These results showed that supplementing hog diets with 1.0% hardwood vinegar may noticeably improve the meat quality of finishing hogs. 본 시험은 육성-비육돈에 대한 생균제, illite, 활성탄 및 목초액이 육질에 미치는 영향을 평가하기 위하여 생균제 0.2%와, illite, 활성탄 및 목초액을 각각 1.0%를 삼원교잡종($Landrace{\times}Yorkshire{\times}Duroc$, 평균체중 $32.3{\pm}1.3 kg$) 육성-비육돈에게 100일간 급여하여 전단가, 보수력, 육즙감량 및 가열감량, 육색, 신선육과 조리육의 관능평가 및 조직감을 분석하였다. 목초액과 활성탄을 각각 1.0% 급여할 경우 유리수분은 대조구에 비하여 낮았으나, 보수력은 높게 나타났다. 육즙감량은 생균제, illite, 활성탄 및 목초액을 급여함으로서 유의적으로 적었으며, 가열감량은 목초액을 1.0% 급여할 경우 적었다. 육색의 명도($L^*$)와 적색도($a^*$) 값은 모든 처리구에서 차이가 없었으나, 황색도($b^*$) 값은 활성탄과 목초액을 1.0%급여할 경우 높았다. 목초액을 1.0% 급여할 경우 신선육의 관능평가에서 육즙감량은 적었으며, 육색은 높았다. 또한 가열육의 경우에도 육색과 육즙 함량은 목초액을 1.0% 급여할 경우 높았다. 따라서, 육성-비육돈 사료에 목초액을 1.0% 첨가 급여할 경우 경쟁력 있는 브렌드 돈육의 생산이 가능하며, 농가소득 증대에 크게 기여할 것으로 기대된다.