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김흥열 ( Heung Yeol Kim ) 대한폐경학회 2008 대한폐경학회지 Vol.14 No.3
Bisphosphonates are widely used, though gastrointestinal tolerance is a problem on daily administration. Intermittent regimen, from once weekly to once yearly, is now available in overseas and can overcome GI adverse events. New generation of anti-resorptive agents (anti-RANKL antibody and a new SERM, bazedoxifene) are promising and will be soon available for the treatment of osteoporosis. Anabolic agents such as teriparatide and strontium ranelate have marked effects on BMD and reduction on fracture risk. While none of these options is suitable for everyone, the range of future available therapies does mean that most patients can find an intervention that is effective and acceptable. Now I introduce new antiresorptive drugs (Denosumab, Integrin inhibitor, Cathepsin K inhibitor) and new bone formation drugs (PTH-Teriparatide, Strontium Ranelate, Antisclerostin Ab-Sclerostin inhibitor, 2MD, Other Wnt-signaling related drugs).
김흥열 ( Heung Yeol Kim ) 대한폐경학회 2007 대한폐경학회지 Vol.13 No.1
일반적으로 폐경여성에서 에스트로겐치료를 하면 열성홍조와 mood disturbances가 좋아지고 수면에 현저한 향상을 느끼지만 모든 객관적인 자료가 치료에 따른 증상의 개선과 항상 일치하지는 않는다. 따라서, 증상 개선의 원인으로 호르몬 치료 및 행동 조건 (behavioral conditioning)이 그 역할을 한 것으로 설명될 수 있으리라 생각되며, 폐경 여성이 수면 장애를 호소할 때 여성 호르몬 부족으로만 생각할 것이 아니라 다른 원인에 대해서도 고려해야 할 것이다.
김흥열 ( Heung Yeol Kim ),김한수 ( Han Soo Kim ),조은별 ( Eun Byul Cho ),박은주 ( Eun Ju Park ),김광호 ( Kwang Ho Kim ),김광중 ( Kwang Joong Kim ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.10
Blue nevus is a neoplasm composed of pigmented dendritic dermal melanocytic cells in the reticular dermis. The lesion clinically presents as a well dermacated cerulean-blue or bluish black colored papule or plaque that usually measure less than 1 cm in diameter. Pilar sheath acanthoma is a rare, benign follicular hamartoma commonly affecting middle-aged and elderly individuals. It is characterized by a small, solitary, skin colored papule situated on the head and neck, particularly around the upper lip. We report a rare case of a blue nevus associated with a pilar sheath acanthoma in a 26 year-old man presented with a bluish papule on the neck. (Korean J Dermatol 2013;51(10):814∼816)
김흥열 ( Heung Yeol Kim ),김병철 ( Byung Chul Kim ),박은주 ( Eun Ju Park ),권인호 ( In Ho Kwon ),김광호 ( Kwang Ho Kim ),김광중 ( Kwang Joong Kim ) 대한피부과학회 2011 大韓皮膚科學會誌 Vol.49 No.7
Squamous cell carcinoma on the lip is a common oral malignancy, and it is responsible for >30% of all oral squamous cell carcinomas. Numerous factors have been implicated in the development of squamous cell carcinoma on the lip, but the most frequently identified risk factors include chronic exposure to ultraviolet radiation. Squamous cell carcinoma on the lip is more prevalent in elderly men, with a male-to-female ratio of 5:1. We report an interesting case of squamous cell carcinoma mimicking herpes simplex on the lip in a 35-year-old woman who presented with erythematous grouped vesicles on the upper lip.
지루각화증과 유사한 임상 양상을 나타낸 안면부 병변의 임상 및 병리조직학적소견에 대한 연구
김흥열 ( Heung Yeol Kim ),김한수 ( Han Soo Kim ),조은별 ( Eun Byul Cho ),박은주 ( Eun Ju Park ),김광호 ( Kwang Ho Kim ),김광중 ( Kwang Joong Kim ) 대한피부과학회 2013 大韓皮膚科學會誌 Vol.51 No.7
Background: The most of typical seborrheic keratoses (SKs) can be clinically differentiated with ease from other dermatoses. However, its differential diagnosis can sometimes be difficult and recently reported cases clinically suggest that SKs with the skin biopsy result being some other diseases can bring on the need for further evaluations. Objective: The aim of this study is to examine the diagnostic yield in submitting clinically diagnosed SKs which showed single discoid lesions of the face for routine microscopic examinations. Methods: We conducted a retrospective review of cases for histological examinations with a clinical diagnosis of SKs or with a differential diagnosis that includes SKs which shows single discoid lesion of the face. A total of 94 pathology reports containing a diagnosis of SKs in the clinical information field were identified. The accuracy of the clinical diagnosis and clinic histopathological correlations were studied. Results: In this study, 45.7% of patients was clinically assumed to have SKs but turned out to be some other diseases according to the histopathology test results - a total of 19 cases (44.2%) with some considered to be precancerous (actinic keratosis 25.6%, benign lichenoid keratosis 16.3% or cancerous (basal cell carcinoma 9.3%, squamous cell carcinoma 4.7%). Conclusion: Lesions suggested to be SKs need more examinations and lesions of atypical clinical appearances which cannot completely exclude the possibility of precancerous or malignant lesions are strongly recommended for skin biopsies. (Korean J Dermatol 2013;51(7):494∼500)
김흥열 ( Heung Yeol Kim ),박새보미 ( Sae Bo Mi Park ),박은주 ( Eun Ju Park ),권인호 ( In Ho Kwon ),김광호 ( Kwang Ho Kim ),김광중 ( Kwang Joong Kim ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.8
Amelanotic maliganat melanoma is a comparatively rare disease. It accounts for 1.8∼8.1% of all malignant melanoma. It is sometime difficult to diagnose amelanotic malignant melanoma because there is no pigmentation, clinically. Polypoid melanoma is a variant of nodular melanoma, which in depth seldom reaches the reticular dermis. The main part of the tumor is located above the nearby epidermis, raised in the form resembling cauliflower. We report a rare case of amelanotic malignant melanoma with polypoid feature in a 78-year-old woman who presented a single bright red nodule on the left thigh.
김흥열 ( Heung Yeol Kim ),박경훈 ( Gyeong Hun Park ),박은주 ( Eun Ju Park ),권인호 ( In Ho Kwon ),김광호 ( Kwang Ho Kim ),김광중 ( Kwang Joong Kim ) 대한피부과학회 2013 大韓皮膚科學會誌 Vol.51 No.6
Background: Melasma has been shown to have a significant emotional and psychological effect on affected patients. Objective: The aim of this study is to evaluate the usefulness of the Melasma Quality of Life Scale (MELASQOL) as compared to Dermatology Life Quality Index (DLQI). Methods: A total of 74 female patients of melasma were asked to complete a questionnaire of MELASQOL, DLQI, and additional demographic data. The degree of melasma was determined on the basis of clinical photos by the investigator using the Melasma Area and Severity Index (MASI). Results: The mean age of these patients was 46.3±8.5 years. The mean MELASQOL score was 39.8±16.03 and the mean DLQI score 6.7±4.41. The MASI and MELASQOL scores showed statistically significant correlations (p<0.01, Pearson correlation=0.373). But, there was no statistically significant correlation between MASI and DLQI scores (p>0.05, Pearson correlation=0.129). Also, multiple linear regression model shows that the correlation of MASI and MELASQOL (standardized coefficient=0.367, p<0.001) is higher than the MASI and DLQI (standardized coefficient=0.139, p>0.05). Conclusion: We suggest that the MELASQOL could be more relevant and useful than DLQI when evaluating the quality of life for melasma patients. It is presumed that the MELASQOL might be helpful in guiding the patient to appropriate treatment methods and in tracking patient`s satisfaction levels.