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신이식 후 호전을 보인 Nephrogenic Fibrosing Dermopathy
김훈수 ( Hoon Soo Kim ),김수한 ( Su Han Kim ),고현창 ( Hyun Chang Ko ),김문범 ( Moon Bum Kim ),송상헌 ( Sang Heon Song ),김정섭 ( Jung Sup Kim ),곽임수 ( Ihm Soo Kwak ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.2
Nephrogenic fibrosing dermopathy (NFD) is a rare cutaneous fibrosing disorder that primarily affects patients with a history of renal disease. NFD manifests with induration, thickening and hardening of the skin with brawny hyperpigmentation. Lesions are typically symmetrical and usually develop on the limbs and trunk. Flexion contractures of the joints may be a feature of the disease. Histopathological features of NFD include proliferation of dermal fibroblasts and dendritic cells, thickened collagen bundles, increased elastic fibers and focal mucin deposition. Although the pathogenesis remains largely unknown, some of the factors implicated in the pathogenesis include renal dysfunction, circulating fibrocytes, vascular injury, and gadolinium which is a contrast material used in magnetic resonance imaging. Currently, no definitive or uniformly effective therapies are available for the treatment of NFD. We herein describe the case of a 44-year-old female NFD patient who undergoes significant improvement of skin lesions and associated joint contracture after renal transplantation. (Korean J Dermatol 2010;48(2):143∼147)
안면부 피부 악성종양의 모즈 미세도식 수술 후 O-Z 피판과 Double O-Z 피판을 이용한 재건술
김훈수 ( Hoon Soo Kim ),정도상 ( Do Sang Jung ),서상희 ( Sang Hee Seo ),고현창 ( Hyun Chang Ko ),김문범 ( Moon Bum Kim ),오창근 ( Chang Keun Oh ),권경술 ( Kyung Sool Kwon ) 대한피부과학회 2009 大韓皮膚科學會誌 Vol.47 No.4
Background: The O-Z flap is a kind of rotational flap that consists of a combination of two opposing rotation flaps. The double O-Z flap is a variant of the O-Z flap applied in multiple adjacent surgical defects that can simplify closure by combining closure into one technique. Objective: To report our experience with the O-Z flap and double O-Z flap in the reconstruction of surgical defects of the face after Mohs` micrographic surgery (MMS), using postoperative clinical and cosmetic results. Methods: Sixteen patients diagnosed with non malignant melanoma skin cancer on the face were treated with MMS. The resultant surgical defects were reconstructed with an O-Z flap in 14 patients and with a double O-Z flap in 2 patients. Clinical outcomes were reviewed, and cosmetic results were scored as excellent, good, fair, poor, or very poor. Results: In the 14 patients using O-Z flap, 6 cases were located on the temple, 4 on the forehead, 2 on the cheek, and 1 of each on the nose and philtrum. Of the two patients using double O-Z flap, one had two adjacent basal cell carcinomas on the cheek, and the other had two adjacent squamous cell carcinomas on the forehead. The size of the primary defects ranged from 1.1 to 2.5 cm in greatest diameter (mean, 1.93 cm). There were no significant local complications. There was no tumor recurrence, and 14 of 16 patients showed satisfactory aesthetic outcomes scored as excellent or good. Conclusion: O-Z flap reconstruction was effective for the closure of surgical defects with limited skin laxity in the face. The double O-Z flap is ideally suited to combine closure of adjacent surgical defects into one technique without exerting undue tension or distorting the surrounding structures. We found these flaps were simple to construct and provided aesthetically pleasing results. Therefore, they could be useful reconstructive options in facial skin defects after MMS. (Korean J Dermatol 2009;47(4):411~418)
호흡기 상피세포에서 MUC5AC와 MUC5B 발현에 대한 Betulinic Acid의 효과
김훈성 ( Hoon Sung Kim ),최윤석 ( Yoon Seok Choi ),이준혁 ( Jun Hyeok Lee ),박나경 ( Na Kyung Park ),박창휘 ( Chang Hwi Park ),이영하 ( Young Ha Lee ),김귀옥 ( Gui Ok Kim ),송시연 ( Si Young Song ),배창훈 ( Chang Hoon Bae ),이승호 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0
Background and Objectives MUC5AC and MUC5B are representative secretory mucin genes in the human airway. MUC5AC and MUC5B expression are increased by a variety of inflammatory mediators. Betulinic acid, a naturally occurring pentacyclic triterpenoid, is known to have an anti-inflammatory property. However, the effects of betulinic acid on mucin secretion of airway epithelial cells still have not been reported. Therefore, in this study, the effect of betulinic acid on inflammatory mediators-induced MUC5AC and MUC5B expression was investigated in human airway epithelial cells. Materials and Method In the mucin-producing human NCI-H292 airway epithelial cells, the effects of betulinic acid on interleukin-1β (IL-1β)-, lipopolysaccharide (LPS)-, and phorbol myristate acetate (PMA)-induced MUC5AC and MUC5B expression were analyzed by reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay. Results Betulinic acid attenuated IL-1β-, LPS- and PMA-induced MUC5B mRNA and glycoprotein expression in NCI-H292 cells. Betulinic acid did not attenuate IL-1β-, LPS- and PMA-induced MUC5AC mRNA and glycoprotein expression in NCI-H292 cells. Conclusion These results suggest that betulinic acid attenuates IL-1β-, LPS- and PMA-induced MUC5B expression in airway epithelial cells. Therefore, betulinic acid may modulate a control of mucus-hypersecretion in airway inflammatory disease. Korean J Otorhinolaryngol-Head Neck Surg 2014;57(8):526-32
Surgical anatomy of head and neck
김훈수 ( Hoon-soo Kim ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.72 No.2
Regardless of beginners and experts, dermatologic surgeons should be well aware of surgical anatomy. Especially, because head and neck areas is closely related to procedures for not only cosmesis but also dermatologic oncology, the thorough knowledge of surgical anatomy of these areas is essential for us. In head and neck area, functionally and cosmetically important structures like eyes, nose and lips are concentrated in relatively small area, and there are several significant variations in the skin of respective anatomic subunits. Also, the relationship to underlying structures like adipose tissue, muscle, cartilage and bone as well as skin of head and neck has distinct features. Therefore, in this lecture, I would like to discuss the fundamental surgical anatomy of head and neck needed for beginners to perform dermatologic procedures.
무기 박막형 보호층을 이용한 고분자 유기발광 다이오드의 특성 평가
김훈,김광호,김재경,이윤희,한정인,도이미,주병권,Kim, Hoon,Kim, Kwang-Ho,Kim, Jae-Kyung,Lee, Yun-Hi,Han, Jeong-In,Do, Lee-Mi,Ju, Byeong-Kwon 한국전기전자재료학회 2003 전기전자재료학회논문지 Vol.16 No.1
In this study, the inorganic thin-film passivation layer was newly adopted to protect the organic layer from moisture and oxygen. Using the electron beam evaporation system, the various kinds of inorganic thin-films were deposited onto the organic layer and their interface properties between organic and inorganic layer were investigated. In this investigation, the MgO layer showed the most suitable properties, and based on this result, the time dependent emission properties were estimated for the OLED with and without passivation layer. In this experiment, we can see that the time-dependent emission properties of MgO passivated OLED had longer life-time compared to non-passivated OLED. Therefore, we can consider that the MgO thin film is one of the most suitable candidates for the thin-film passivation layer of OLED.