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      • KCI등재

        백내장 수술 후 후낭혼탁 발생 억제에 대한 트라닐라스트의 유용성

        김호영,이헌일,전연숙,김재찬,Ho Young Kim,Hyeon Il Lee,Yeoun Sook Chun,Jae Chan Kim 대한안과학회 2008 대한안과학회지 Vol.49 No.12

        Purpose: To evaluate the inhibitory effect of tranilast on the formation of posterior capsular opacity (PCO) after a cataract operation ex vivo and in a rabbit model. Methods: A human lens epithelial cell line (B3) was treated with 0.005-0.1 mM tranilast. Cytotoxicity assessment and effective dosage determination of tranilast were performed using MTT assays. B3 cell lines were cultured in Eagle's minimal essential medium (EMEM) containing 20% FBS with different concentrationsof tranilast, and morphological differences were observed. To investigate the effect of tranilast on cytokine production in B3 cell lines, cells were treated with 0.01 mM tranilast and expression profiles of cytokines were analyzed by RT-PCR. After performing phacoemulsification and intraocular lens implantation in 10 white rabbits, 0.5% tranilast eye drops were given 4 times per day, and the severity of PCO was evaluated bi-weekly using POCOman for 8 weeks after the operation. Results: Cell death was observed in the 0.05 mM tranilast-treated B3 cell lines, and inhibition of epithelial- mesenchymal transition (EMT) was also observed in the 0.01 mM tranilast-treated B3 cell lines. TGF-β1/2, IL-18, and CDK7 mRNA expression decreased in the 0.01 mM tranilast-treated B3 cell lines. Significant suppression of PCO formation was observed in rabbits treated with 0.5% tranilast eye drops 5 weeks post operative (p<0.05). Conclusions: The results from this study show that tranilast suppresses EMT through inhibition of TGF-β, IL-18,and CDK7 expression. The results suggest that tranilast can be used toprevent PCO formation after cataract surgery.

      • SCOPUSKCI등재

        열 기포에 의한 고체 박막의 변형 해석

        김호영,이윤표,Kim, Ho-Young,Lee, Yoon-Pyo 대한기계학회 2003 大韓機械學會論文集B Vol.27 No.2

        Thermal bubbles find their diverse application areas in the MEMS (MicroElectroMechanial Systems) technology, including bubble jet printers, microactuators, micropumps, etc.. Especially, microactuators and micropumps, which use a microbubble growing by a controlled heat input, frequently involve mechanical and thermal interaction of the bubble with a solid structure, such as a cantilever beam and a membrane. Although the concept is experimentally verified that an internal pressure of the bubble can build up high enough to deflect a thin solid plate or a beam, the physics of the entire process have not yet been thoroughly explored. This work reports the experimental study of the growth of a thermal bubble while deflecting a thin cantilever beam. A physical model is presented to predict the elastic response of the cantilever beam based on the experimental measurements. The scaling law constructed through this work can provide a design guide for micro- and nano-systems that employ a thermal bubble for their actuation/pumping mechanism.

      • 20d<sub>b</sub> 정착길이를 가지는 SD700 갈고리철근과 확대머리철근의 정착성능 실험

        김호영,심혜정,Kim, Ho Young,Sim, Hye Jung 인천대학교 도시과학연구원 2018 도시과학 Vol.7 No.2

        With the increase of the skyscraper center, the development of large-diameter and high-strength reinforcing bars is being carried out to solve the dense reinforcement. In case of the steel reinforced concrete with a small cross section such as beam-column joints, the development length becomes short when straight bars are used. Therefore, it is possible to solve the problem that the development length becomes short by using the bearing strength of the hooked bar and headed bar. In this study, the exterior beam-column joint test of SD700 hooked bar and headed bar with anchorage length of 20db was conducted to extend the development length limitation of hooked bar and headed bar. As a result of the evaluation of the anchorage strength using the design equation by KCI, the average of the [measured value]/[predicted value] ratio was 1.31 for the hooked reinforcing bars. In the case of headed bars, the average of the [measured value]/[predicted value] ratio was 1.12. In addition, in order to compare the anchorage performance of the hooked bar and the headed bar, the measured values were divided by the square root of the compressive strength of the concrete to compare the anchorage strength. Under the same conditions, the anchorage strength of headed bars was 8.5% higher than the hooked bars.

      • 물 위에 뜬 소금쟁이 다리의 탄성 변형

        박건중(Kun Joong Park),이덕규(Duck-Gyu Lee),김호영(Ho-Young Kim) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.5

        Water strider legs, capable of enduring much heavier load than their body weight, are flexible. As a model for the legs, we study how floating flexible sheets in static equilibrium are deformed by hydrostatic pressure and surface tension using the linear theory of elasticity and the Young-Laplace equation. We also consider the maximum load supported by the sheets. The predictions agree well with experimental measurements.

      • KCI등재

        문화,문학 : 영화 <아바타>에 나타난 육체성 연구

        김호영 ( Ho Young Kim ) 경희대학교 비교문화연구소 2012 비교문화연구 Vol.29 No.-

        This paper aims to look into various symbolic meanings of the body shown in the film, Avatar (2009, James Cameron), and to ponder over a variety of media strategies carried by the pursuit of the corporality shown in this film. In a nutshell, the body in Avatar is a symbol of primitiveness rather than civilization, and the body language is a fundamental and effective means of communication much better than verbal language. A variety of physical contacts that appeared in many scenes of the movie emphasizes the role of the body as a means of real communication. Also, in the composition of the film dominated by the confrontation of civilization, numerous creatures in the planet Pandora with a variety of colors as well as a number of agencies and large body sizes express primitive richness. The narrative of the film telling the story of a ``moving`` body ultimately emphasizes the superiority of the body with respect to consciousness, unlike the narrative of conventional movies dealing with the problems of the body. In addition, the corporality pursued by this film implies several important media strategies. It may reveal a self-reflection of the material civilization and the imperialism, or, on the contrary, an attempt to conceal or dilute them. It may also represent a self-reflection of the overdeveloped media technology, or simply the dilution of it. Finally, it may be an attempt to recover the feeling of "presence", not fully supported by the 3D technology, by the identification of the spectator`s body and the character`s body.

      • KCI등재
      • KCI등재

        불확정성의 기호로서의 프레임

        김호영 ( Kim Ho Young ) 한국기호학회 2017 기호학연구 Vol.53 No.-

        회화에서 프레임은 단순한 틀과 한계 이상의 기능을 수행한다. 그림의 영역을 한정하고 그것의 내적 질서와 의미작용을 보장해주는 절대적 경계가 아니라, 이미지와 실재 사이의 끊임없는 틈입, 치환, 확장을 지향하는 비-결정적 경계이다. 프레임은 분리이자 연결이고, 한정이자 위반이며, 닫힘이자 열림인 이중적 속성의 경계다. 또 자신의 내재적 결핍 뿐 아니라 그림 내부의 결핍을 지시함으로써, 혹은 자신의 내재적 불확정성 뿐 아니라 그림 내부의 불확정성을 드러냄으로써 회화 전체를 불확정성의 텍스트로 만드는 ‘불확정성의 기호’이다. 즉 프레임은 그 자체의 불확정성을 통해 회화의 불확정성을 나타내고 작품의 의미 고정을 끊임없이 지연시키며, 그에 따라 회화를 영원히 의미 생성 중인 영역으로 만드는 기호이다. 본 논문에서는 이러한 관점들을 바탕으로 불확정성의 경계 또는 기호로서의 프레임의 특성들에 대해 살펴본다. 먼저, 기호적 절단 혹은 기호적 재봉으로서의 프레임의 특성에 주목하면서 그 내부에 바깥과 열림을 지향하는 ‘위반’이 본질적 속성으로 내재되어 있음을 고찰한다. 또한 데리다의 파레르곤 개념을 재검토하면서 오브제로서의 프레임에도 ‘안이자 바깥’으로서의 이중적 속성이 근원적으로 내포되어 있음을 논한다. 나아가, 프레임이 그림 내부의 결핍과 불확정성을 지시하는 기호이자 그 스스로 불확정성을 내포하고 있는 기호임을 밝히면서, 궁극적인 의미와 힘의 방향 자체가 바깥을 향해 있는 일종의 ‘탈영토화’의 기호임을 살펴본다. Immanuel Kant has determined the concept of parergon as an extra appetizer that comes in addition, outside the field clean, namely incidental business, activity or operation that comes next or everything against ergon. He cited as examples the frames of the paintings, the clothes of the statues or the columns around the architectures. But Jacques Derrida considered that as a parergon, the frame in painting works not only as frame-object, frame-limit and frame-window, but also as edge which, neither simply outside nor simply inside, separates the inside from outside into same time does not stop linking them. Then, it emphasizes that the frame is not an addition hors d’oeuvre that will eventually be forced to disappear, to sink, to fade and merge into the realm of significance, at the moment when it deploys his greatest energy. The framework must therefore be considered as an edge of indecidablility, or as a sign of difference, whose general principle is no longer a mechanical law of the nature, of the agreement, or of the harmony of the immanent signs, but a certain repeated dislocation or a regulated and irrepressible deterioration which makes it crack in general, the corner abyss in its angles and its articulations, returns its internal limit in external limit.

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