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Prostaglandin A₂-induced Apoptosis is Not Inhibited by Heme Oygenase-1 in U2OS Cells
Kyoung-Won Ko(고경원),Sun-Young Lee(이선영),Ji-Hyun Ahn(안지현),Jaetaek Kim(김재택),In-Kyung Kim(김인경),Ho-Shik Kim(김호식) 한국생명과학회 2008 생명과학회지 Vol.18 No.11
Prostaglandin A₂ (PGA₂)는 사람 골육종 세포인 U2OS 세포주에서 apoptosis와 heme oxygenase (HO)-1의 발현을 함께 유도하였다. PGA₂에 의한 apoptosis는 HO-1의 과도한 발현이나 HO-1에 대한 small interfering RNA에 의한 발현저하에 의하여 변동되지 않았으나 H₂O₂에 의한 세포사망은 HO-1의 발현 수준에 반비례하여 변동되었다. 또한 thiol antioxidant인 N-acetyl-L-cysteine (NAC)은 PGA₂에 의한 세포사망과 HO-1의 발현 증가를 모두 차단하였지만, non-thiol antioxidant인 butylated hydroxyanisole (BHA)과 ascorbic acid는 세포사망과 HO-1의 발현 유도를 차단하지 않았다. 이와 같은 결과들은 PGA₂는 산화성 손상에 의해서가 아니라 PGA₂의 thiol-reactivity에 의하여 apoptosis와 HO-1의 발현을 유도하며, HO-1의 발현은 PGA₂에 의한 apoptosis와는 독립적인 현상이거나 기능적으로 apoptosis 유도의 하부에 위치하고 apoptosis의 진행에는 기여하지 않을 것이라는 것을 시사해 준다. Prostaglandin A₂ (PGA₂), one of cyclopentenone PGs, induced both apoptosis and heme oxygenase (HO)-1 expression in U2OS cells. PGA₂-induced apoptosis was not perturbed by either over-expression or knock-down of HO-1, whereas H₂O₂-induced cell death was inversely modulated by the expression level of HO-1. In addition, N-acetyl-L-cysteine (NAC), a thiol antioxidant, blocked both apoptosis and HO-1 expression induced by PGA₂. But, non-thiol antioxidants like butylated hydorxyanisole (BHA) and ascorbic acid did not block either apoptosis or HO-1-induction. Taken together, these results suggest that PGA₂ induces both apoptosis and HO-1 expression, which are critically related to the thiol-reactivity of PGA₂, but not oxidative stress, and HO-1 expression may be independent or functionally located downstream of apoptosis by PGA₂ without contribution to apoptosis progression.
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김주필(Joo Pil Kim),예성훈(Seong Hun Ye),이준기(Jun Gi Lee),이준호(Jun Ho Lee) 한국거미연구소 2015 한국거미 Vol.31 No.1
한국산 거미 목록을 최근 분류체계와 새롭게 추가된 분류군을 총망라하여 재정리하였다. 그 결과, 한국산 거미류의 수는 총 48과 281속 795종으로 조사되었으며, 이전 김과 김(2010)의 발표보다 2과 16속 69종이 많았다. 이전의 김과 김(2010)의 목록에서 이용된 분류체계와 비교해 크게 변동된 사항으로는 기존의 코리나거미과(Family Corinnidae)에 속하는 3개 속(Genus Cetonana 괴물거미속(개칭), Genus Paratrachelas 어리괭이거미속, Genus Trachelas 괭이거미속)과 2개 속(Genus Orthobula 십자삼지거미속, Genus Phrurolithus 도사거미속)이 각각 괭이거미과(Family Trachelidae)(신칭)와 도사거미과 (Family Phrurolithidae)(신칭)로 분리, 신설되었으며(Ramírez, 2014), 밭고랑거미과(Family Liocranidae)의 족제비거미속(Genus Itatsina)이 미투기거미과(Family Miturgidae)의 1속(Genus Prochora)에 하위 동종이명(synonymy)으로 편입됨(Bosselaers & Jocqué, 2013)에 따라 Prochora 속의 국명이 족제비거미속으로 개칭되었다. 또한 오소리거미과(Family Zoridae)가 미투기거미과(Family Miturgidae)에 하위 동종이명으로 편입되었으며(Ramírez, 2014), 기존에 미투기거미과에 속해 있던 1속(Genus Cheiracanthium 어리염낭거미속)이 미투기거미과로부터 분리, 신설된 장다리염낭거미과(Family Eutichuridae)(신칭)로 분류되었다(Ramírez, 2014). 그 밖에 속, 종의 단위에서 분류군 신설, 동종이명, 오동정 등의 분류 체계 변동 사항이 있었으며, 이를 본 목록에서 확인할 수 있다. 더불어 근래에 추가된 2종의 무자격명(Nomen nudum) 처리된 종과, 국립공원 생물종 목록집(2012)에 기재되었으나 논문으로 정식 발표되지 않은 미기록종 22종을 별도로 기술하였다. 한국산 거미류는 접시거미과(101종), 꼬마거미과(84종), 왕거미과(79종), 깡충거미과(73종), 그리고 늑대거미과(57종) 이하 순으로 종수가 많았으며, 위의 5과가 전체 종수의 약 50%(394종)을 차지하였다. 전체 795종 중 한국산 고유종은 173종(21.8%)이었고, 일본산 거미류와 512종(64.4%), 중국산과 497종(62.5%), 러시아산과 360종(45.3%), 대만산과 103종(13.1%) 동일종이었다. 또한, 구북구산(Palearctic region)이 80종(10%), 전북구산(Holarctic region)이 37종(4.7%), 그리고 세계공통종(Cosmopolitan species)이 13종(1.6%)으로 분석되었다. A revised new-version of the check list of Korean spiders, including recent systematic systems and new taxa, is presented in this paper. According to additional references in the last 5 years, a total of 795 species of 281 genera belonging to 48 families were checked in Korean spider fauna, and there are 69 species of 16 genera belonging to 2 families more than the previous check list(Kim & Kim, 2010). Typical examples of some changes in systematic systems of Korean spiders compared with the previous check list(Kim & Kim, 2010) are as follows : Two families, the family Trachelidae and the family Phrurolithidae, previously in the family Corinnidae are raised to family status(by Ramírez, 2014). In Korea, the family Trachelidae includes 3 genera(Gen. Cetonana, Gen. Paratrachelas, Gen. Trachelas) and the family Phrurolithidae includes 2 genera(Gen. Orthobula, Gen. Phrurolithus); The family Eutichuridae is raised to family status, which was previously in the family Miturgidae(by Ramírez, 2014). There is one genus(Gen. Cheiracanthium) in the family Eutichuridae in Korea; The family Zoridae is included as a junior synonym of the family Miturgidae(by Ramírez, 2014); The genus Itatsina is included as a junior synonym of the genus Prochora in the family Miturgidae(Bosselaers & Jocqué, 2013). One Pisaurid species(Dolomedes jirisanensis) and a Sparassid genus(Gen. Joopilia, Joopilia joopilis) are nomina nuda. Additionally, There are 22 unrecorded species, which was found by Korean National Park Research Institute(2012) but was not described as papers, check list of them is presented separately from the check list of Korean spiders in this paper. Linyphiidae(101 sp.), Theridiidae(84 sp.), Araneidae(79 sp.), Salticidae(73 sp.), and Lycosidae(57 sp.) spiders are the most in the Korean spider fauna, and species in that 5 families formed about 50%(394 sp.) of the whole Korean spiders. In zoogeographical distribution, Korean spider fauna was found containing 80 Pa, 37 Holarctic, 13 Co, and 173 Korean endemic species. And comparison with faunas of neighboring countries, 512 species of Korean spiders also live in Japan(64.4%), 497 species live in C(62.5%), 360 species live in Russia(45.3%) and 103 species live in Taiwan(13.1%).
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慕齋 金安國의 ‘北學’ - ‘다시, 실학이란 무엇인가?’를 묻는다 -
김호 ( Kim Ho ) 서울대학교 국사학과 2024 한국사론 Vol.70 No.0
Today, South Korea has achieved global success in science, technology, and popular culture, but it also faces serious social challenges, including a declining birthrate, aging population, regional decline, and wealth polarization. How can Korea maintain a “descent community” in the 21st century? The purpose of this article is to explore “practical learning in contemporary Korea” based on the academic theory of Kim An-guk, who prepared for the “age of neo-Confucianism” in the 16th century. Kim criticized exam-oriented study for career advancement and emphasized the practice needed for the new era. The new academic movement aimed to demonstrate public mindedness for the well-being of the community beyond oneself and family. To put it more simply, the preceding research on practical learning was shaped by the rejection of Neo-Confucianism as a ‘useless discipline’. Is the identity of Neo-Confucianism inherently ‘hypocritical’? What practices are necessary for the sustainability of Korea as a community today? Recalling Professor Han Young-woo’s lifelong question, “What is true learning?”, I wanted to ask “practical learning for now” to address the various social challenges facing contemporary Korea.
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김호동 ( Ho Dong Kim ) 한국행정사학회 2008 한국행정사학지 Vol.23 No.-
If Dokdo is a Korean territory and is a subordinate island to Ulleungdo, this is written from the perspective that we need to discuss what historical status Dokdo and Ulleungdo have had from ancient times in the local administrative system. From 512 when Usanguk surrendered to Shilla, to the early of the 11th century when was the reign of King Hyeonjong in Goryeo, Usanguk belonged to Shilla and Goryeo, it did not belong to the local administrative unit, but it was a country which had an originality. Usanguk collapsed after the invasion of the Jurchen, after that, it was the object of Goryeo`s management and the people movement to the other area. So, it has the name of Ulleungdo, Mureungdo which included in the local administrative system. However, it was from Usan-mureung-deungcheo-Anmusa dispatched in King Taejong that Dokdo belonged to the local administrative system. At the result, Sejongsillokjiriji had Ulleungdo and Usando(Dokdo) as a subordinate island of Uljin Prefecture, Samcheokdohobu, Gangwondo. Ulleungdo and Dokdo were subordinate islands under the direction of Kangwon governor, it did not set up Eup after all. They were not a county and prefecture unit because they were under the Swaehwan management or Sunsim policy. After establishing the system of territory defence in the middle of the 17th century, the reign of King Sukjong, Ulleungdo was protected the territory every three years by Samcheokcheomsawa and Wolsongmanho. Matters concerned affairs transferred the central government to Kangwondo. However, the governor of territory defence in Ulleungdo has not discovered the trace of searching in Dokdo until now. Even though Ulleungdo reclaimed in 1883, it was not a county and prefecture unit because Ulleungdo belonged to Uljin-hyeon, or Pyeonghae-gun. Korea issued Imperial Decree No. 41 of Oct. 15, 1900, which Ulleungdo elevated to Uldo county and was one of 27 independent counties and prefectures in Kangwondo. Seokdo or Dokdo was under the jurisdiction of Ulleungdo, Dokdo settled as a subordinated island of Ulleungdo. On the other hand, in case of Japan, Dokdo belonged to Shimane Prefecture by Shimane Prefectureal Notice in 1905. It takes notice that the decisive power on the establishment of county and prefecture and the transfer of the servants in county and prefecture was the affairs of a central government, not the competence of a local government.
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김만일 ( Man Il Kim ),박영규 ( Young Gyu Park ),김을영 ( Eul Young Kim ),김양빈 ( Yang Bin Kim ),용환호 ( Hwan Ho Yong ),지원현 ( Won Hyun Ji ) 대한지질공학회 2010 지질공학 Vol.20 No.4
This study assessed the hydrogeological characteristics of a seepage area of white leachate. The geological characteristics of the leachate were determined by a surface survey, and an electrical resistivity survey and borehole image processing system (BIPS) were applied to estimate the distribution of discontinuities, to assess the geological structure of the seepage areas. Fluctuations in groundwater level within boreholes were measured during periods of precipitation in the dry and wet seasons. The results show that electrical resistivity is lower in the seepage section than in non-seepage sections. The distribution of fracture zones and limestone cavities was inferred from the logging data and BIPS data. Variations in groundwater level and groundwater recharge, related to rainfall events, show the direct effect of rainfall events during the rainy season. We obtained a strong relationship between seepage amount and rainfall (correlation coefficients of 0.83-0.97).
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