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신이식후 당뇨병의 특성 및 유발인자에 대한 임상적 분석
윤선애(Sun Ae Yoon),김현웅(Hyun Eung Kim),김용수(Yong Soo Kim),윤영석(Young Suk Yoon),방병기(Byung Kee Bang),김희제(Hee Je Kim) 대한내과학회 1991 대한내과학회지 Vol.40 No.1
In order to assess the clinical characteristics and risk factors of post-transplant diabetes, the courses of 437 renal transplants (former nondiabetics), who received transplants between March, 1969 and May, 1990 in Catholic University Medical College, were reviewed retrospectively. 37 (8.5%) of 437 renal transplants manifested posttransplant diabetes. This incidence was much higher than usual incidence of diabetes (3.5%) in Korean population (p=0.000). The hyperglycemia was found in postoperative 1 to 108 months (median; 3 months), and followed up 3 to 103 months (37±26 months). We simultaneously tested the effects of age, sex, type of immunosuppressants and donor relationship on posttransplant diabetes statistically and found female prevalence (p=0.013). Gene frequency of HLA Bw62 antigen in posttransplant diabetics (21.6%) was higher than that (8.5%) in general population (p=0.004). The actuarial patient and graft survivals in post-transplant diabetics were greater than those in Azathio-prine and prednisolone treated patients, and similar to those in Cylosporine A and prednisolone treated patients. We conclude that posttransplant diabetes is of greater prevalence in female and renal transplants expressing HLA Bw62 antigen, and does not ameliorate the patient and graft survivals after renal transplantation.
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