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뇌 허혈시 Nimodipine 의 뇌신경손상 예방효과에 대한 실험적 연구
김해규,정규섭,김인세,김성수,유시정 대한마취과학회 1990 Korean Journal of Anesthesiology Vol.23 No.4
Cerebral autoregulation is the mainternance of a constant cerebral blood flow over a wide range of cerebral perfusion pressure. But irreversible hypoxic brain damage may occur as a consequence of such diverse conditions as lung and heart disease, shock, seizure or an episode of severe hypotension, and is potential hazard to any patient undergoing general anesthesia. The ultimate degree of neurological recovery may range from brain death and vegetative state to minor psychiatric disturbance and even normality, and is determined by the severity of the initial stress and wheather or not adequate resuscitation was commenced before irreversible brain damage. We performed an experiment to determine the protective effect of the calcium channel blocker nimodipine on the neuronal injury following cerebral ischemia in a rat model. The result were as follows: 1) Mean arterial pressure decreased more significantly in the nimodipine-treated group than the saline-treated group (p$lt;0.01). 2) With respect to the degree of neuronal damage following cerebral ischemia, it decreased more significantly in the nimodipine-treated group than the saline-treated group (p$lt;0.01).
기관내 삽관시 혈역학적 변화에 대한 Nicardipine의 효과
김해규,변경조 부산대학교 병원 암연구소 2007 부산대병원학술지 Vol.- No.21
Background: Laryngoscopy and tracheal intubation often provoke an undesirable increase in blood pressure and heart rate. Nicardipine-induced reduction in blood pressure was greater with inhalational anesthetics than nicardipine alone. This study was designed to determine the optimal dose of nicardipine for acceptable hemodynamic change during inhalation with sevof1urane. Methods: Forty ASA physical status I patients were randomly allocated into three groups, control, NIC15, and NIC30. After intravenous thiopental 5 mg/kg, vecuronium 0.13 mg/kg 15 ㎍/kg (NIC15) or 30 ㎍/kg (NIC30) of nicardipine or same amount of normal saline (Control) was given intravenously followed by mask ventilation of three minutes with sevoflurane, nitrous oxide and oxygen. Tracheal intubation under direct laryngoscopy was performed after then. Heart rate, blood pressure, and cardiac output were measured at the period of baseline, preintubation, immediately after intubation until time of peak value. Results: After tracheal intubation, the increase of systolic blood pressure was suppressed significantly by NIC30 and NICl5 group compared with the control group. The increase of heart rate after tracheal intubation was least in the NIC15 group. The cardiac output was significantly increased only in NIC15 group. Conclusions: These results suggest that both 15 and 30 ㎍/kg of nicardipine are the appropriate dose of nicardipine during induction with sevoflurane for attenuation of pressor responses to laryngoscopy and intubation in healthy patients.
김해규,0,현정,정진우 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.23
Purpose: In 1922 in the United States, Edward Link presented his homemade flight simulator, which became common place in both military and civilian aviation, known as the "Link Trainer". Mter then simulators were also introduced in medical education as a tool to make advanced training standardized, less expensive, and without danger to those involved. Mannequin simulators used for medical simulation education, training, and research is developed, tracing the motivations, evolution to commercial availability, and efforts toward assessment of efficacy of those for teaching cardiopulmonary resuscitation (CPR) for medical personnel and emergency medical technicians (EMT), cardiology skills,anesthesia clinical skills, and crisis management. Subject and Methods: This study aimed to investigate the efficacy of use of simulation on the education of hospital emergence system. We randomly divided 40 nurses into two groups, one had a debriefing and the other did not have a debriefing after simulation. We measured the score for three educational objects, evaluation of the patient (diagnosis), proper management of airway (airway), and proper cardiopulmonary resuscitation (CPR). Results: All the objects were improved after debriefing or no-debriefing but the group of debriefing was much highly improved than that of no-debriefing except CPR score. Conclusion: From these results simulation education with debriefing may be a better method for the education of emergency system in hospital.