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필치가 혈중 알코올농도와 간세포내 알코올대사 효소 활성에 미치는 영향
이오미(O Mi Lee),예충민(Choong Min Ye),최병철(Byung Chul Choi),이지윤(Ji Yun Lee),강혜정(Hye Jeong Kang),최윤경(Yun Kyung Choi),김창종(Chang Jong Kim),심상수(Sang Soo Sim) 대한약학회 2005 약학회지 Vol.49 No.4
To investigate the effect of Feelch on alcohol metabolism, we measured both blood alcohol concentration in human and hepatic alcohol metabolizing enzyme activity in rats. The blood alcohol concentration in Feelch-ingested group was significantly lower than that in water-ingested group at 0, 40, and 80 minute after alcohol intake. The blood alcohol concentration between male and female taken 300 ㎖ of 21% alcohol showed the significant differences; the peak value of blood alcohol concentration in male and female were 0.0837±0.014% and 0.108±0.018%, respectively, In alcohol-fed rats, aldehyde dehydrogenase (ALDH) activity was significantly increased, whereas alcohol dehydrogenase (ADH) activity was not changed. In both Feelch-fed group and Feelch plus alcohol-fed group, ADH and ALDH activity were significantly increased as compared with each control group. Feelch decreased phospholipase A₂ activity and lipid peroxidation in hepatic tissue and activities of serum aminotransferases as compared with control. These results suggest that Feelch may have a hepato-protective effects and this is likely due to lower blood alcohol concentration via the increment of hepatic ADH and ALDH activity.
흰쥐에서 HELIKITTM의 급성 및 아급성 경구독성시험
김창종(Chang Jong Kim),조철형(Chul Hyung Cho),최현호(Hyun Ho Choi),심상수(Sang Soo Sim),김정례(Jeong Rye Kim) 대한약학회 1999 약학회지 Vol.43 No.2
Acute and subacute oral toxicity of HELIKITTM (13C-urea) were carried out in Sprague-Dawley rats of both sex. The toxicity of HELIKITTM was compared with urea (12C-urea which is used for control). In acute toxicity studies, we daily examined number of deaths, clinical signs, body weights and pathological examination for 14 days after single oral administration of HELIKIT or urea (12C-urea) at a dose of 5000mg/kg. The subacute oral toxicity was investigated in Sprague-Dawley rats treated with HELIKITTM at a dose of 40, 200 and 1,000mg/kg/day or 12C-urea at a dose of 1,000mg/kg/day for 4 weeks. In acute toxicity studies, HELIKITTM and urea did not show any toxic effect in rats and oral LD50 value was over 5,000mg/kg in rats. In subacute toxicity studies, no death occurred and no drug-related changes were found in clinical observations: body weight, food consumption, opthalmoscopy, auditory test, urinalysis, hematology, blood chemistry, gross pathological examination or organ weight between HELIKITTM, urea and control groups. In histopathological examinations, the slight thickening of mucosa of the limiting ridge in the stomach was noted in the animals treated with HELIKITTM at a dose of 1,000mg/kg/day and also the changes in urea group at a dose of 1,000mg/kg/day was found, but all of these changes in the stomach regressed after withdrawal of the test article for 2 weeks and reversibility of the effect was revealed. These results indicate that the non toxic dose level of HELIKITTM was 1,000mg/kg/day in the 4 weeks-repeated dose study, suggesting that the substitution of 13C for carbon in urea molecule has no effect on the toxicity of urea and changes in stomach are reversible.