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The proteomic landscape shows oncologic relevance in cystitis glandularis
김준용,한도현,김혜윤,정민선,유한석 대한병리학회 2023 Journal of Pathology and Translational Medicine Vol.57 No.1
Background: The relationship between cystitis glandularis (CG) and bladder malignancy remains unclear. Methods: We identified the oncologic significance of CG at the molecular level using liquid chromatography-tandem mass spectrometry-based proteomic analysis of 10 CG, 12 urothelial carcinoma (UC), and nine normal urothelium (NU) specimens. Differentially expressed proteins (DEPs) were identified based on an analysis of variance false discovery rate < 0.05, and their functional enrichment was analyzed using a network model, Gene Set Enrichment Analysis, and Gene Ontology annotation. Results: We identified 9,890 proteins across all samples and 1,139 DEPs among the three entities. A substantial number of DEPs overlapped in CG/NU, distinct from UC. Interestingly, we found that a subset of DEP clusters (n = 53, 5%) was differentially expressed in NU but similarly between CG and UC. This “UC-like signature” was enriched for reactive oxygen species (ROS) and energy metabolism, growth and DNA repair, transport, motility, epithelial-mesenchymal transition, and cell survival. Using the top 10 shortlisted DEPs, including SOD2, PRKCD, CYCS, and HCLS1, we identified functional elements related to ROS metabolism, development, and transport using network analysis. The abundance of these four molecules in UC/CG than in NU was consistent with the oncologic functions in CG. Conclusions: Using a proteomic approach, we identified a predominantly non-neoplastic landscape of CG, which was closer to NU than to UC. We also confirmed a small subset of common DEPs in UC and CG, suggesting that altered ROS metabolism might imply potential cancerous risks in CG.
김준용,김진태 한국도로학회 2015 한국도로학회 학술발표회 논문집 Vol.2015 No.3
국내에서는 19990년대 초반 혼잡, 비혼잡 등 으로 표현 가능한 접근로별 교통조건에 따라 신호현시를 동적으로 조정 가능한 실시간신호제어시스템을 개발하였다. 실시간신호제어시스템 내에서 주기결정 및 신호현시 배분을 위한 핵심 분석지표로 사용되고 있는 변수가 포화도(DS, Degree of Saturation)이다. 포화도는 전체 녹색시간 중 차량 통행에 사용된 시간의 비율을 의미한다. 포화도에 대해 일반적으로 교통 조건이 혼잡해 짐에 따라 포화도도 비례하여 증가할 것이라는 개념을 가지고 있으나 현장자료를 바탕으로 한 정량적인 분석은 현재까지 이루어진 바가 없다. 본 연구에서는 교통조건에 따른 포화도 변화에 대한 정량적 분석을 수행하였다. 포화차두시간의 변동성을 확인하기 위하여 본 연구에서는 실시간 신호제어시스템 COSMOS(Cycle, Offset, Split Model of Seoul)의 운영결과자료를 활용하였다. COSMOS가 운영되었던 포스코사거리의 2 개월에 걸친 운영 결과자료를 사용하였으며(2006.9~2006.10) 해당 자료는 신호주기별/접근로별 자료로 구분되어 있다. 수집자료에 포함된 지표들 중 포화차두시간의 변동성을 판단하기 위하여 V/g(교통량/녹 색시간)과 DS(Degree of Saturation)의 관계를 분석 하였다. V/g(교통량/녹색시간)은 주어진 신호조건 과 교통조건을 반영한 지표이며, DS는 COSMOS 내부에서 포화교통류율을 도출하기 위하여 사용되는 지 표로서 유효녹색시간당 손실시간을 제외한 실점유시간의 합으로 설명할 수 있다. V/g-DS 관계를 회귀분 석 의하여 선형, 2차, 파워, 대수 형태로 분석한 결과는 다음과 같다.
김준용,Jin-Yong Joung,강지영,손창규,조정효 대한한의학회 2015 대한한의학회지 Vol.36 No.4
More and more patients suffering from hepatitis A, the number of patients representing symptoms that are uncharacteristic to hepatitis A is also increasing. There are occasions of serious complications among adult hepatitis A patients that can cause fulminant hepatitis or cirrhosis which can be fatal. A 43-year-old male was diagnosed as acute hepatitis A and was treated at a Western hospital over the course of three months, which included two months of hospitalization. However, his symptoms did not improve, so he was admitted to Oriental hospital. We prescribed Chunggan extract (CGX) four times a day. Acupuncture was performed twice a day. From the twenty-fourth day of admission, the total bilirubin fell under 10 mg/dL for the first time and next day he was discharged. Following his discharge, he consistently took CGX three times a day. 21 days after discharge all of his symptoms disappeared. This study demonstrated that traditional Korean medicine (TKM) for acute viral hepatitis with cholestatic hepatitis might be effective and safe with no adverse effects.
Building a Private Cloud-Computing System for Greenhouse Control
김준용,이춘구,박동혁,박현동,이중용 한국농업기계학회 2018 바이오시스템공학 Vol.43 No.4
Purpose: Cloud-computing technology has several advantages, including maintenance, management, accessibility, and computing power. A greenhouse-control system utilizing these advantages was developed using a private cloud-computing system. Methods: A private cloud needs a collection of servers and a suite of software tools to monitor and control cloud-computing resources. In this study, a server farm, operated by OpenStack as a cloud platform, was constructed using servers, and other network devices. Results: The greenhouse-control system was developed according to the fundamental cloud service models: infrastructure as a service, platform as a service, and software as a service. This system has four additional advantages - security, control function, public data use, and data exchange. There are several considerations that must be addressed, such as service level agreement, data ownership, security, and the differences between users. Conclusions: When the advantages are utilized and the considerations are addressed, cloud-computing technology will be beneficial for agricultural use.