Virus-like Particle (VLP) Mediated Antigen Delivery as a Sensitization Tool of Experimental Allergy Mouse Models

김주형,오지인,강천식,최윤수 대한면역학회 2020 Immune Network Vol.20 No.4

Antigen delivery systems play critical roles in determining the quality and quantity of Ab responses in vivo. Induction of protective antibodies by B cells is essential in the development of vaccines against infectious pathogens, whereas production of IgE antibodies is prerequisite for investigation of allergic responses, or type 1 hypersensitivity reactions. Virus-like particles (VLPs) are efficient platforms for expression of proteins of interest in highly repetitive manners, which grants strong Ab responses to target antigens. Here, we report that delivery of hen egg lysozyme (HEL), a model allergen, through VLP could provoke strong HEL specific IgE Ab responses in mice. Moreover, acute allergic responses were robustly induced in the mice sensitized with VLPs that express HEL, when challenged with recombinant HEL protein. Our data show that antigen delivery in the context of VLPs could function as a platform for sensitization of mice and for subsequent examination of allergic reactions to molecules of interest.

Deep Inside #1608 Thermal transper printing on polyester fabric, 140×285cm, 2016

김주형 서울여자대학교 조형연구소 2016 조형연구 Vol.22 No.-

신앙생활이 건강에 미치는 영향에 대한 체계적 접근

김주형 한국개혁신학회 2012 한국개혁신학 Vol.33 No.-

Christians living in the post-modern period should be able to view the world and its cultures with multi-perspectives. It will help us to understand the world we are living in and to change it in a biblical way. Likewise, Approaching the issue of health at different perspectives will bring us to promoting the health of people in a more holistic way. In the modern medicine, different modalities to deal with mental and physical diseases have been developed, that even includes psychosocial interventions. However, christianity and the applications of its contents, that have traditionally been considered to be effective and well accepted in handling diseases among the believers , were relatively neglected and treated as a non-scientific method for preventing and treating diseases. In the current article, the author showed the association of mental health and social relationship among general people with physical health using articles published in scientific journals. Christian lifestyles such as participating in the church worship, private prayer, and bible reading appeared to greatly influence physical health among the church goers in a health promoting way. It seemed that the christian lifestyles affect the physical health through improved mental health and strengthened social support among the practitioners. This finding was also explained theologically. Holy Spirit can affect cognition, affection, and volition of christians through its power, bearing the fruit of the Spirit, which is closely associated with positive mental health and social relationship. It is, then, logically possible to mention that Holy Spirit may affect the physical health of the christians by promoting mental health and social support. In a word, the holistic change of health among the christians take place through "Unio cum Christo" and "Duplex Gratia". Implications of the findings were addressed. 포스트모더니즘 시대에서 기독교 신자들은 종교개혁에서 출발한 개혁주의 세계관을 담지하고 세상과 문화를 다관점적으로 바라보아야 한다. 즉, 세상을 보는 눈을 여러 각도에서 보는 것은 세상을 이해하고 변화시키는데 필요하다는 것이다. 건강을 접근하는 데 있어서도 다양한 관점은 건강의 증진을 위해 꼭 필요하다. 국민 건강에 대한 다관점적인 접근이라는 측면에서 현대 의학과 보건학에서 상대적으로 소홀하게 취급한 분야가 있다. 그것은 종교이며 특별히 기독교 신앙생활이다. 본 논문에서는 의과학연구에서 밝혀진 대로 정신건강과 사회적 건강이 신체적 건강에 영향을 주는 것을 고찰하였고 기독교 신앙생활이 정신과 신체적 건강을 향상시켜 신체적 건강을 증진할 수 있음을 객관적인 자료를 통해 제시하였다. 또한 성령의 역사를 통하여 신자들이 예수와의 연합됨으로 개인의 칭의와 성화가 이루어지고 삶에서 성령의 열매가 형성된다는 관점은 신앙생활과 건강의 긍정적인 관계의 존재가 신학적으로도 충분한 근거가 있다는 것을 보여주는 것이라고 할 수 있다. 요약하면 필자는 이 논문에서 하나님과의 관계를 증진하는 신앙생활은 정신건강과 사회적 관계의 증진 등 전인건강에 기여할 수 있다는 논지를 객관적인 자료와 신학적인 근거를 통해 그 타당성을 보여주었다고 사료된다.

생각이 비로 내리는 날

김주형 서울여자대학교 조형연구소 2017 조형연구 Vol.23 No.-

스마트시티와 도시계획

김주형 (사)한국도시계획가협회 2017 Urban planners Vol.4 No.2

Al-Cu 다결정 리본의 응고거동에 미치는 휠조건의 영향

김주형,이상목,홍준표 ( Ju Hyung Kim,Sang Mok Lee,Chun Pyo Hong ) 한국주조공학회 1997 한국주조공학회지 Vol.17 No.3

N/A The effect of wheel surface condition on solidification behavior of Al-Cu ribbon was investigated in order to establish extreme levels of heat extraction. The condition of wheel surface was changed either by heating the wheel surface up to 200℃ or by coating boron nitride(BN) onto the rim of a wheel. Heating the wheel surface up to 200℃ improved the wetting behavior between the molten metal and the rotating wheel, leading to an increase in the ratio of columnar structure to the entire thickness of Al-4.3wt%Cu and Al-33.2wt%Cu ribbons. For Al-4.3wt%Cu ribbon, assuming one grain as a single heterogeneous nucleation event at the contact point, the nucleation density with the wheel surface heated to 200℃, was 4×10^6/㎟, and in the cases of BN coating with thin and thick layers, 10^5/㎟ and 5×10⁴/㎟, respectively. The largest cooling capacity of the wheel corresponded to the heated wheel surface, and as the thickness of BN coating layer increased, the cooling capacity of the wheel gradually decreased.

A Robust Approach for Efficient Sodium Storage of GeS₂ Hybrid Anode by Electrochemically-driven Amorphization

김주형 한국공업화학회 2021 한국공업화학회 연구논문 초록집 Vol.2021 No.0

민주적 혁신의 정치이론: 역동적 민주주의를 향하여

김주형,서현수 한국정치학회 2023 한국정치학회보 Vol.57 No.1

The concept of democratic innovations refer to the institutions, processes, and movements which seek to renovate and reconstruct the traditional forms of representative politics through the widening and deepening of citizen participation. In this article, we try to lay the theoretical ground for such innovative practices. We make two arguments. First, and at the level of democratic institutions, we suggest a model of dynamic democracy that creatively combines instances of representation, participation, and deliberation. Second, and at the level of citizenship, we argue that democratic innovations should aim to foster critical and participatory citizenship as a long-term goal rather than remain fixated on achieving immediate policy goals at hand.

CNF의 내부 기공에 Zn-Mg의 친리튬 촉매를 적용하여 가역적 리튬을 유도하는 CNF 집전체가 적용된 리튬 금속 배터리 개발

김주형,조민기,최재홍,이채원,오필건,손윤국 한국공업화학회 2022 한국공업화학회 연구논문 초록집 Vol.2022 No.-

액상 유기 레이져 (Liquid Organic Lasers)

김주형 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0

Liquid organic semiconductors present strong advantages over conventional semiconductors in solid state, such as solvent-free device processing, ultimate mechanical flexibility and uniformity, and tunable optoelectronic responses. In a lasing context, these fluidic semiconducting materials can provide an excellent framework for flexible and tunable lasers. Particularly since distributed feedback (DFB) structures show outstanding properties for lasing such as low threshold, high optical mode confinement, and high reflectivity, the compact integration of DFB grating structures into optofluidic organic light-emitting devices is of strong interest for the development of tunable solvent-free liquid lasers. Here optically-pumped low-threshold blue, green and red liquid DFB lasers using solvent-free fluidic organic semiconductors and flexible polymeric substrates with DFB gratings are presented. Experimental results also indicate that a tuning of the flexible liquid DFB laser emission peak can be achieved under mechanical bending, due to the highaspect- ratio DFB grating pattern which causes diversified periods according to the mechanical deformation. Overall, the results strongly suggest great potential for a wide range of optoelectronic applications.