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연고제(軟膏劑)의 경도(硬度)에 관(關)한 연구(硏究) 1. 약전수재연고제(藥典收載軟膏劑)의 외견상(外見上)의 대수경도(對數硬度)
김종갑,Kim, Johng-Kap 한국약제학회 1971 Journal of Pharmaceutical Investigation Vol.1 No.1
The ointment, had discovered and used from the ancient, have not ever defined to qualitity as the hardness concerned with the absorned With the absorption of the effect of durg through the skin. Auther, for the first time, suggest the apparent logarithmic hardness against the penetration of ointment registered on the pharmacopeia of the Republic of Korea, the results are as the followings. 1. The speciality of this apparent logarithmic hardness ie in proportion for the solidity on the contrary to the penetration of oiniment, and the distribution range of it are between 1.68 to 3.53 for their ointments examined. 2. The specific gravity of the verious ointments according to the apparent logarithmic hardness may be ignore on the calculaiotn, the mean valve of the samples was 2.9303. 3. The determination of apparent logarithmic hardness(H) by the penetration method follows the under equation. $H=log_{10}({\frac{P-0.545h^3}{0.855h^2}})$ where, the h is the penetrate length described centimeter, and p is the weight of the cone.
연고제(軟膏劑)의 경도(硬度)에 관한 연구(硏究)(III) -수종(數種)의 분말약제(粉末藥劑)가 연고제(軟膏劑)의 대수경도(對數硬度)에 미치는 영향(影響)-
김종갑,김기성,이숙경,Kim, Johng-Kap,Kim, Kie-Sung,Lee, Sook-Kyung 한국약제학회 1975 Journal of Pharmaceutical Investigation Vol.5 No.3
The relationship between powders and apparent logarithmic hardness of ointments were clearly demonstrated. The followings were obtained as the results. 1. Apparent logarithmic hardness of ointment were affected by the powders such as zinc oxide, salicylic acid, soluble starch. and talc. 2. The ointments which are added powder have different two slops, $k_1\;and\;k_2$. 3. The slopes, $k_1\;and\;k_2$ were directly correlated and the critical points, were proportional to $k_1\;and\;k_2$ values. 4. The slope, ka is at least $6{\sim}91$ times more sensitive, than the slope, $k_1$, and 25 times more sensitive in average. It was suggested from the results that the quantity of powers which is added to the ointment must be within the critical point.
연고제(軟膏劑)의 경도(硬度)에 관(關)한 연구(硏究) ( II ) -약전수재연고제(藥典收載軟膏劑)의 외견상(外見上)의 대수경도(對數硬度)-
김종갑,이숙향,Kim, Johng-Kap,Lee, Sook-Kyung 한국약제학회 1974 Journal of Pharmaceutical Investigation Vol.4 No.1
According to previous paper, the hardness of semi-solid as ointments and suppositories causes the tough or skin, the pain and connected with absorption, the state of spread or the efficiency of drug. When the hardening agent or the softening agent is added to ointment whid, is registered on the pharmacopeia of the republic of Korea, the experimertal data by apparent logarithmic hardness are shown is Table 1. The results are as the folloring. 1) In case of the softening agent which is added to ointment base, each has shown two different equation with differnented slope as $K_1$ and $K_2$ value determined (Fig. 1,2). 2) When the hardening agent is added to same ointment base, these studies indicated that there is a direct correlation between $K_1$ and $K_2$. However, in case of softening agent $K_1$ and $K_1$ are not correlated as indicated in Fig. $3{\sim}8$. 3) On condition of same ointment base, the critical poit is proportional to $K_1$ 4) The second effect is at least $3{\sim}17$ times more. sensitive than the first effect or in average 8.3 times more sensitive, Therefore, the results presented in this paper. Suggest that, when the drug is added to a certain ointment base, it should be added within this first effect before the critical point is reached.
Piroxicam - Cyclodextrin 포접화합물의 Suspension 에 대한 Bioavailavility 의 연구
김종갑(Johng - Kap Kim),박선희(Sun - Hee Park),김형민(Hyung - Min Kim) 한국약제학회 1988 Journal of Pharmaceutical Investigation Vol.18 No.4
Inclusion complexes of piroxicam with α, β and γ-cyclodextrins were prepared and suspended to enhance the bioavailavility of piroxicam. A HPLC analysis was employed for the determination of piroxicam in the rabbit serum after a single oral dose in suspension of piroxicam and each of inclusion complexes of piroxicam with α, β and γ-cyclodextrins. The bioavailability and serum level of piroxicam from β-cyclodextrin inclusion complexes was higher than those of piroxicam and the other complexes administered, and the total area under the curve of serum concentration versus time for their inclusion complexes were larger than that of piroxicam.
Fenbufen 좌제의 물리화학적 특성 및 생체이용률에 관한 연구
김종갑 ( Kim Johng Kap ),홍순억 ( Hong Soun Uk ) 한국약제학회 1984 Journal of Pharmaceutical Investigation Vol.14 No.1
Suppositories containing Fenbufen were made by the Fusion method with Witepsol H-15, Wecobee and PEG 1540 bases. In order to produce an exact dosage form, displacement value-and other values were determined. The release rates were determined with the K. P. dissolution apparatus and with cellophane tube dialysis device and they were found to be; PEG 1540> Witepsol H-15> Wecobee. The bioavailability of Fenbufen after rectal administration was PEG 1540> Witepsol H-15> Wecobee which correlates with the in vitro release.
Methampicillin Lysinate의 합성 및 항균작용
김종갑(Johng Kap Kim),이숙경(Sook Kyung Lee) 대한약학회 1977 약학회지 Vol.21 No.4
Since ampicillin, one of the important semi-synthetic derivatives of penicillins, is restricted in use because of its unfavorable physico-chemical and pharmacological properties, the author synthesized a new derivative, methampicillin lysinate and its physical and characteristics were determined. The antibacterial activity of this compound against ten species of Gram positive and negative bacteria in vitro showed that it was more active to Gram negative bacteria than the positive and that was three times more potent than ampicillin trihydrate.
Oil-Water Interface Transfer of Cefoperazone Pivaloyloxymethyl Ester
최영욱,김종갑,Choi, Young-Wook,Kim, Johng-Kap 한국약제학회 1989 Journal of Pharmaceutical Investigation Vol.19 No.1
Kinetic and thermodynamic aspects of the interface transfer of cefoperazone and its pivaloyloxymethyl ester were studied in a two-phase system composed of aqueous buffers and n-octanol by using the absolute reaction rate theory. In terms of the net thermodynamic parameters for the process, ${\Delta}S$ increased and ${\Delta}F$ decreased as the lipophilicity increased. With the increased ratio of forward $(k_f)$ to backward rate constants $(k_b)$, the ester was more lipophilic than cefoperazone, but the aqueous solubility was reduced.