갑상선 수질암 환자에서 칼시토닌 정상화와 관련된 예후인자

김정한,김상욱,남석진,서정민,양정현,Jeong-Han Kim,M.D.,Sang-wook Kim,M.D.,Seok-Jin Nam,M.D.,Jeong-meen Seo,M.D. and Jung-Hyun Yang,M.D. 대한갑상선-내분비외과학회 2003 The Koreran journal of Endocrine Surgery Vol.3 No.2

Purpose: Medullary thyroid carcinoma (MTC) is an uncommon thyroid tumor. Calcitonin (CT) is a very specific marker of this cancer and has a major place in the postoperative follow-up. The aim of this study was to evaluate the outcome of surgical treatment for MTC and to identify the prognostic factors for the normalization of CT after surgery. Methods: Retrospective analysis of 29 patients with MTC from 1994 to 2002 in Samsung Medical Center was carried out. Results: 22 female and 7 male were identified and their mean age was 46.9 years. Mean follow-up was 42.7 months. 5 patients had MEN2a; all had pheochromocytoma and 2 among them had hyperplasia of parathyroid gland. The majority of patients (86.2%) presented with a palpable neck mass and 23 patients were diagnosed with MTC preoperatively. Total thyroidectomy with or without neck dissection was performed in all patients. Cervical lymph node involvement was detected in 34.5% of these patients. Basal CT levels were found to be normal in 15 patients (51.7%) postoperatively. 1 distant metastasis, 6 loco-regional metastases and 1 death were observed during follow-up period. Overall survival rate was 94.7% and disease-free survival rate was 62.9% at 5 years. Univariate analysis showed that extra-thyroidal invasion and involvement of lymph node were significant prognostic factors for normalization of CT after surgery. Conclusion: Considering the high recurrence rate in the thyroid bed and cervical lymph node, more extensive and thorough neck dissection is needed for the treatment of MTC. (Korean J Endocrine Surg 2003;3:121-126)

족근골 유합의 발생 빈도: 단일 기관 자기공명영상 분석

김정한,곽희철,이창락,김영준,김전교,이선주,이정한,박준호,Kim, Jung-Han,Gwak, Heui-Chul,Lee, Chang-Rak,Kim, Young-Jun,Kim, Jeon-Gyo,Lee, Sun-Joo,Lee, Jeong-Han,Park, Jun-Ho 대한족부족관절학회 2016 대한족부족관절학회지 Vol.20 No.3

Purpose: Tarsal coalition results from defects during the developmental stage and produes ankle pain and limitations in the range of motions. Its incidence has been reported to be 1%, but there has not been any reports with respect to Koreans. Therefore, we evaluated the prevalence of tarsal coalition in Koreans. Materials and Methods: Between 2005 and 2014, we analyzed a total of 733 cases of foot and ankle magnetic resonance imaging (MRI) in our hospital. There were 391 men and 342 women. All MRI readings were read by a radiologist in our hospital. We classified the coalitions in accordance with the histological and anatomical characteristics, and calculated the prevalence in each group. Moreover, we tried to determine the prevalence of tarsal coalitions in accordance with sex, age, and proportion of the symptomatic tarsal coalitions. Results: There were a total of 11 MRIs of tarsal coalition - 9 talocalcaneal coalitions, 1 calcaneocuboidal coalition, and 1 calcaneonavicular coalition. Nine tarsal coalitions were observed in men and 2 in women. Conclusion: Through this study, we found that the prevalence of tarsal coalition, including the asymptomatic patients, is similar to the previously known prevalence (1%). By getting more MRIs of the foot and ankle, we could better represent the prevalence of tarsal coalitions in Koreans.

농약의 물리화학적 특성 연구 (II) Flupyrazofos의 수용성, 가수분해, 증기압, 옥탄올/물 분배계수

김정한,김용화,김균,Kim, Jeong-Han,Kim, Yong-Hwa,Kim, Kyun 한국응용생명화학회 1997 Applied Biological Chemistry (Appl Biol Chem) Vol.43 No.1

국내에서 최초로 합성, 개발된 유기인계 살충제인 flupyrazofos(KH-502)의 물리화학적 특성으로 수용성, 가수분해, 증기압, 분배계수를 EPA와 OECD 방법에 준하여 측정하였다. 수용성은 $25^{\circ}C$에서 0.80 ppm으로 낮았고 가수분해 반감기는 $25^{\circ}C$에서 266.5시간(pH 4.0), 180.0시간(pH 7.0), 120.9시간(pH 9.0)으로 알칼리 조건에서 불안정하였으며 $40^{\circ}C$에서는 $25^{\circ}C$보다 $2{\sim}4$배 정도 가수분해가 빠르게 진행되었다. 상은($25^{\circ}C$)에서의 증기압은 $2.81{\times}10^{-5}$ torr로 측정되었고, 다른 두 온도(35, $45^{\circ}C$)에서 증기압을 측정하여 log P=0.673-(1565.4/T)라는 관계식을 구하였다. Flupyrazofos의 상온($25^{\circ}C$)에서의 증기압은 diazinon과 유사한 수준이었고, DDVP보다는 약 1,000배 정도 낮은 수치로 휘발에 의하여 환경에 영향을 미칠 가능성은 낮을 것으로 판단되었다. Flupyrazofos의 옥탄올/물 분배계수치를 보면(log Kow=5.24) 먹이연쇄를 통한 생물농축이 예상되나 비교적 가수분해가 빠르기 때문에 비록 수계에 노출된다고 하여도 그 가능성은 매우 낮을 것으로 사료된다. Several physicochemical properties such as water solubility, vapor pressure, hydrolysis and octanol/water partition coefficient(Kow) of flupyrazofos, the first organophosphorus insecticide developed in Korea, were measured based on EPA and OECD methods. Water solubility was low showing 0.80 ppm at $25^{\circ}C$ and in hydrolysis study, half-life at $25^{\circ}C$ was 266.5 hr(pH 4.0), 180.0 hr(pH 7.0) and 120.9 hr(pH 9.0) demonstrating instability in alkaline solution. At $40^{\circ}C$ hydrolysis rate was $2{\sim}4$ times higher than that at $25^{\circ}C$. The equation log P=0.673-(1565.4/T) was obtained from vapor pressure experiments at three different temperatures (25, 35, $45^{\circ}C$) and $2.81{\times}10^{-5}$ torr was obtained at $25^{\circ}C$. This value is similar to that of diazinon and 1,000 times lower than that of DDVP suggesting it would not give environmental contamination by volatilization. High log Kow(5.24) was observed and this might result in bioconcentration through food chain. However, its possibility is not likely to be high due to its relatively rapid hydrolysis.

ISSUE - 저독성 작물보호제(농약) 시대와 식량 생산

김정한,Kim, Jeong-Han 한국작물보호협회 2015 자연과 농업 Vol.311 No.-

전에는 한말이면 벌레가 모두 죽었는데?

김정한,Kim, Jeong-Han 한국작물보호협회 2006 자연과 농업 Vol.27 No.1

회원작품: 창원시립 문신 원형 전시관

김정한,Kim, Jeong-Han 대한건축사협회 2011 建築士 Vol.2011 No.5

동결과정 중의 어육의 열력학적 특성에 관한 연구 -II 가열 및 동결 과정 중의 어육의 열물성 변화-

김정한,최영준,김민용,공재열,KIM Jeong-Han,CHOI Yeung-Joon,KIM Min-Yong,KONG Jai-Yul 한국수산과학회 1991 한국수산과학회지 Vol.24 No.5

각종 어육의 동결 및 가열과정 중의 이화학적 품질변화의 규명하고 저온저장 및 가열조건의 확립과 장치의 설계를 위하여 필요로하는 열물성과 변성온도를 DSC를 이용 측정함으로서 다음의 결과를 얻었다. 1. 어육의 발열반응개시온도는 냉각속도가 증가할수록 강하하였으며, 활성화에너지, 엔탈피 및 엔트로피는 냉각속도의 증가와는 상반되는 경향을 보였다. 동결잠열은 냉각속도에 관계없이 거의 -정한 값을 나타내었다. 2. 어육의 동결과정 중의 자유에너지의 변화는 냉각속도와 조성성분의 영향보다는 온도에 의한 영향이 큰 것으로 나타났다. 3. 어육속의 지질 및 단백질의 변성온도는 가열속도와 상관관계를 나타내었으며, 지질의 함양이 많을수록 변성온도가 낮게 나타났다. 변성엔탈피는 각각 0.04-0.13, 0.07-0.17cal/g 값을 얻었다. On heating and fleering food-stuffs, it is very important to obtain informations about thermophysical properties of fishes for designing of freezing and heating equipment and analyzing of physico-chemical reaction during storage. It is particularly necessary to measure denaturation enthalpy, temperature, latent heat of freezing, activation energy, enthalpy, entropy and free energy on freezing and heating rate. In this study, DSC was used to study effects of freezing and heating rate on thermophysical properties and denaturation temperature on scanning rate $2.5-10.0^{\circ}C/min$. On increasing scanning rate, denaturation temperature of protein and lipid incresed and freezing point, activation energy, enthalpy, entropy were decreased. In freezing process free energy of fishes were found to be $14.2-18.9 kcal/mol$.

유기인계 화합물의 산화대사중 반응성 중간체와 반응기작에 관한 고찰

김정한,박창규 ( Jeong Han Kim,Robert F . Toia,Chang Kyu Park ) 한국환경농학회 1996 한국환경농학회지 Vol.15 No.2

Organophosphorus pesticides, which are an important part of synthetic pesticides in current use contain sulfur atom in their molecules and can be activated or detoxified by environmental and/or biological metabolism. Among the related metabolic reactions, oxidative processes are particularly important with their final products and the study on the reactive intermediates formed in those reactions is essential to elucidate the metabolic pathways and mechanisms and to understand the toxicological properties. This review dealt with the reactive intermediates formed in various reactions from the structural and mechanistic point of view for organophosphorus pesticides and related compounds.

제초제에 잘 안죽는 잡초도 생겼다는데?

김정한,Kim, Jeong-Han 한국작물보호협회 2006 자연과 농업 Vol.27 No.2

느타리버섯 병재배 면실박 대체배지 선발

김정한,하태문,주영철,Kim, Jeong-Han,Ha, Tae-Moon,Ju, Young-Cheol 한국버섯학회 2005 한국버섯학회지 Vol.3 No.3

톱밥:비트펄프:면실박(50:30:20) 배지의 면실박 대체배지로서 아주까리박, 유채박을 사용한 경우 C/N율은 대조와 유사하였고, 야자박, 코코넛박을 이용한 배지에서는 대조보다 높은 C/N율을 나타났다. 아주까리박, 유채박 사용시 배양일수는 2~5일, 초발이소요일수는 2일 지연 되었고 수량 또한 대조보다 20g이상 낮게 나타났으며 야자박, 코코넛박 사용시 배양일수는 3일 지연되었으나 수량은 관행재배 128g/병과 비슷하게 나타났다. 경제성 분석결과, 미송톱밥:비트펄프:면실박(50:30:20)의 관행재배에서 면실박 대체배지로 야자박, 코코넛박을 이용시 1000병규모로 연간 8.2회 재배 경우 소득이 각각 2,864천원, 2,733천원으로 관행재배의 2,849천원 대비 101%, 96%의 소득지수를 보였다. Main materials used as media for oyster mushroom cultivation are pine sawdust, beet pulp, cotton seed pomace. Increases in the price and the unbalance of demand and supply of cotton seed pomace was often damage to oyster mushroom cultivation farm, so we investigated agricultural by-product to replace the cotton seed pomace for bottle cultivation of oyster mushroom. Treatment of coconut oil meal or coconut pomace delayed incubation period about 3 days compared with cotton seed waste treatment(control), but yield and income index showed similar to each other in three treatment. Consequently coconut oil meal and coconut pomace could select for cotton seed pomace substitute.