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선천성 고혈압 쥐에서 시상하부 카테콜아민성 신경계에 미치는 난소 스테로이드 호르몬의 영향
김운자(Oon Ja Kim),고광호(Kwang Ho Ko) 대한약학회 1991 약학회지 Vol.35 No.5
A question whether abnormal responsiveness of hypothalamic catecholaminergic nervous system to ovarian steroid hormones in spontaneously hypertensive rats (SHR) exist was investigated. Four groups of experimental animals were prepared for SHR and normotensive Wistar rats (NW) respectively: 1) intact, 2) ovariectomized (OVX+V), 3) ovariectomized and estrogen treated (OVX+E), 4) ovariectomized and estrogen plus progesterone treated (OVX+E+P) groups. Hypothalami from experimental animals were dissected out and used for determination of alpha-adrenergic receptor binding characteristics and catecholamine contents. Norepinephrine(NE) content and Bmax of alpha1-adrenergic receptors in hypothalami were greater in intact SHR than in intact NW, but dopamine(DA) content was lower in SHR than in NW. Neither contents of NE and DA nor binding characteristics of alpha1-adrenergic receptors were different in OVX+V and OVX+E group from intact group of both SHR and NW. Kd and Bmax of alpha1-adrenergic receptors in OVX+E+P was lower than that in intact SHR but not in NW. DA content was lower in OVX+E+P than in intact group of SHR and NW. The result of the present study indicates that there is an abnormal responsiveness of hypothalamic catecholaminergic nervous system to ovarian steroid hormones in SHR which may be one of genetically-determined factors probably not responsible for the development of hypertension.
노환성,김운자,박건구,조영환,박형섭,Ro, Hwan-Seong,Kim, Oon-Ja,Park, Kun-Ku,Cho, Young-Hwan,Park, Hyung-Sup 한국약제학회 1994 Journal of Pharmaceutical Investigation Vol.24 No.4
Development of hyperlipidemic animal model is prerequisite for the screening of drugs lowering the blood lipoprotein level. In this study, two kinds of diet regimens were tried for the hyperlipidemic effect. The model will be used for the screening of current prescriptions to a variety of diseases related to hyperlipidemia by practioner of traditional herbal medicine. Fifteen male Wister rats of 200g were divided into three groups, and given normal, or either one of the two high cholesterol diets for up to 2 weeks. Regimen HC-1 and regimen HC-2 contained I% and 2% cholesterol in diet, respectively. Total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL) and lower density lipoprotein cholesterol (LDL) levels in the serum were measured before the start of the diet, at 1 week after the start, and at 2 week point. Both regimens resulted in hyperlipidemia with the typical characteristics of increase in TC and LDL, and reduction in HDL, and showed no observable side effects such as diarrhea. In conclusion, both of HC-1 and HC-2 regimens appeared appropriate as diet regimens for the hyperlipidemic rat model.
고지혈증 랫트를 이용한 수종 전통 한약제의 항고지혈 효과
노환성,고우경,김운자,박건구,조영환,박형섭,Ro, Hwan-Seong,Ko, Woo-Kyoung,Kim, Oon-Ja,Park, Kun-Koo,Cho, Young-Hwan,Park, Hyung-Sup 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.4
Three herbal medicine recipes were tried on the animal model of diet induced hypercholesterolemia to screen for the lipid-lowering effect. The recipes adopted were based on the prescription for atherosclerosis-related symptoms by folk-medicine practioners. Hyperlipidemia was induced in rats by giving the high lipid/cholesterol diet for 7 days. Then, the recipes started with the normal diet. Blood was sampled at 1,2,3 and 5 week-points of the treatment, and levels of total cholesterol, triglyceride, high density lipoprotein and lower density lipoprotein were measured. Dae-shiho-tang decreased total cholesterol level significantly. Hwangryun-haedok-tang and Samhwang-sasim-tang slightly decreased total cholesterol level, although it was not statistically significant.
신국현,이은방,송영진,김운자,Shin, Kuk-Hyun,Lee, Eun-Bang,Song, Young-Jin,Kim, Oon-Ja 한국생약학회 1992 생약학회지 Vol.23 No.3
The deodorizing responses of the steam distillate from some medicinal plants(G-3) on three representative malodors were evaluated by estimating the best estimate threshold(BET) of odor responses. With a single spray of G-3, the BETs of malodors such as ammonia, acetic acid, and ethyl acetate were found to increase 4.11, 32.6 and 13.1 fold, respectively, which indicated G-3 possessed a potent deodorizing activity. The deodorizing potency of G-3 was also demonstrated to be as high as and even higher than those of the commercial deodorizing agents.
수종 생약 수증기 증류물이 유기인제 농약에 의하여 저해된 Acetylcholinesterase 활성에 미치는 효과
신국현,이은방,송영진,김운자,Shin, Kuk-Hyun,Lee, Eun-Bang,Song, Young-Jin,Kim, Oon-Ja 한국생약학회 1992 생약학회지 Vol.23 No.2
The acute toxicity and the effect of steam distillate obtained from several plant mixtures (G-3) on the reactivation of brain, lung, and blood acetylcholinesterase (AChE) activity, and recovery from other toxic symptoms following intoxication by organophosphate pesticides were investigated in mice and mudfish. Administration of G-3 $(50{\sim}100\;ml/kg,\;i.p.)$ immediately or 30 min prior to Diazinon or Sumithion treatments, respectively, resulted in a significant reactivation of AChE activity in brain, lung, and blood, their potencies being almost equipotent to those of 2-PAM, one of well-known antidotes. G-3 itself exhibited almost no acute toxicity even at the highest dose employed, and without effect on the inhibition of hepatic drug metabolism function following organophosphate administrations. G-3 showed a significant diminution of the death rate in mudfish as well as in mice intoxicated by Diazinon.
효모에서 발현된 유전자 재조합 GM-CSF의 일반 약리작용
이은방(Eun Bang Lee),김운자(Oon Ja Kim) 대한약학회 1991 약학회지 Vol.35 No.2
The general pharmacological tests with rhGM-CSF indicated that it had no influences on rotarod and locomotor activity tests, but shortened hexobarbital-sleeping time at the large dose of 3mg/kg, s.c. in mice. It elicited no hypothermic, analgesic and antiepileptic action. No influences on blood pressure and respiration in rabbits were observed at the dose of 1mg/kg, i.v. and it did neither affect the receptors of adrenaline, acetylcholine, serotonin, histamine, kinin and oxytocin, nor antagonize the actions of histamine, serotonin and oxytocin at its concentrations of 1X10-6g/ml. However, this substance was demonstrated to stimulate the formation of leucocytes in rats.
감마 인터페론, LBD-001의 Adjuvant 관절염 억제작용 및 기타 일반 약리작용
이은방(Eun Bang Lee),김제현(Jae Hyun Kim),김운자(Oon Ja Kim),김정근(Jung Keun Kim) 대한약학회 1990 약학회지 Vol.34 No.3
The recombinant gamma-interferon (LBD-001) which was produced by yeast as host system was investigated on the pharmacological activities. This gamma-interferon exhibited potent inhibitory effect on adjuvant induced arthritis, but no effect on carrageenin induced paw edema in rats. It did not show any sedative, anticonvulsive, analgesis and hypothermic activities in animals. It also had no influences on isolated tracheal and ileum of guinea pig, isolated uterus and fundus strip of rats, and on blood pressure and respiration in situ experiments of rabbits.
효모에서 발현된 유전자 재조합 인간 성장호르몬의 일반 약리작용
이은방(Eun Bang Lee),신국현(Kuk Hyun Shin),정명숙(Myung Sook Chung),김운자(Oon Ja Kim),윤기영(Ki Young Yoon),김정근(Jung Keun Kim) 대한약학회 1990 약학회지 Vol.34 No.6
The general pharmacological actions of recombinant human growth hormone (rHGH) were investigated. It had hypothermic action but neither sedative nor analgesic action. No pharmacological effects were observed in isolated guinea pig ileum and tracheal muscle and rat fundus and uterus. Slight hypotensive action with no effect on respiration was revealed at a dose of 20 IU/kg i.v. of rHGH in rabbits. The rHGH exhibited a weak inhibitory action of glucose tolerance in normal rats, significantly lowered the blood glucose contents in adrenalectomized rats 20 min after i.v. administration (80IU/kg), and produced a significant inhibitory effect on in vitro glycerol release in epinephrine-stimulated epididymal fat pad segments of rats.
효모에서 발현된 유전자 재조합 탈메치오닌 인간 성장호르몬의 일반 약리작용
이은방(Eun Bang Lee),신국현(Kuk Hyun Shin),김운자(Oon Ja Kim),윤기영(Ki Young Yoon),천선아(Seon Ah Cheon),채윤정(Yun Jung Chae) 대한약학회 1992 약학회지 Vol.36 No.1
The general and some other pharmacological actions of growth hormone without N-terminal methionine(rhGH) were investigated in animals. The hormone had no influenced on the central nervous system and on body temperature at a high oral dose of 40IU/kg in animals. It had neither analgesic nor antiepileptic actions at the High doses. In the isolated ileum and trachea of guinea-pig and isolated stomach fundus and uterus of rat, it showed neither contractive nor relaxing effets at a concentration of 1 X 10-3IU/ml in bath, and no inhibitory action at a dose of 1 X 10-3IU/ml against the contractions produced by histamine (5 X 10-5g/ml), serotonin(1 X 10-5g/ml, acetylcholine(1 X 10-5g/ml) and oxytocin(5 X 10-3IU/ml). Furthermore, the intravenous infection of 20IU/kg rhGH had no influences on the normal blood pressure and respiration in rabbits. These negative results in pharmacological profile are thought that the hormone may not elicit serious side effects On the other hand, the rhGH exhibited a weak inhibitory action of glucose tolerance in normal rats, significantly lowered the blood glucose contents in adrenalectomiglucose tolerance in normal rats, significantly lowered the blood glucose contents in adrenalectomized rats 20 min after i.v. administration of 80IU/kg, and showed a significant inhibitory effect on in vitro glycerol release in epinephrine-stimulated epididymal fat pad segments of rats.