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김옥녀,이상복 최신의학사 1978 最新醫學 Vol.21 No.3
Eucommia ulmoides Oliver which belongs to Eucommiaceae family, has been used in the chines medicine as well as in the folk remidies. It is advocated that this herb exerts good therapeutic effects on a large variety of disorders, e.g. neuralgia, hypertension etc. by analgesic, tranquilizing and hypotensive effects. However the basic pharmacology and the mechanism of hypotensive action are not clear. This experiment was carried out in order to evaluate the hypotensive action of Eucommiae cortex methanol extract (EM) and to clarify the mechanism of action in the rats. The results of the experiments were as follows: 1) Blood pressure manifested gradual responses by the fall of -20.1, -29. 8 and -54.2 mmHg in proportion to the administration of 30, 60 and 80 mg/kg of EM respectively. 2) Prior administration of atropine attenuated the decrease in blood pressure induced by EM (60 mg/kg) slightly, but not significantly. 3) Prior administration of diphenhydramine attenuated significantly the decrease in blood pressure induced by EM (60 mg/kg) . 4) Prior administration of dichloroisoproterenol did not blocked the decrease in blood pressure induced by EM (60 mg/kg) . 5) Administration of epinephrine (20 mg/kg) to the rat pretreated with EM (60 mg/kg) did not show difference in the increase of the blood pressure compared with that of normal rat.
김옥녀,강진숙,이진경 한국병원약사회 1994 병원약사회지 Vol.11 No.2
Lithium is indicated in the treatment of recurrent bipolor disorders and mania. Because lithium has a narrow therapeutic range, it needs therapeutic drug monitoring and dosage regimen through serum lithium concentration. The dissolution test and the content uniformity test are necessary to secure safety, efficacy and quality control. These tests were performed to compare their efficacy among preparations with same active ingredient and its amount. Those were used as a method in measuring bioavailability of each product. The materials were four lithium carbonate tablets which were made in four different manufacturers(A. B, C and D). the results were as follows. 1) The dissolution test was performed for an hour using paddle method, in the solution of distilled water and artificial gastric juice. Dissolution rates(%) for 30 minutes(D_(30)min-) of all products were more than 60%. 2) In the content uniformity test, all the content of products were more than 95%. The result showed a nonsignificant difference in the dissolution rate and the content uniformity.
김옥녀,이진경,강진숙,안정순,신가식 한국병원약사회 1992 병원약사회지 Vol.9 No.4
The Dissolution Test and the Content Uniformity Test are necessary to secure safety, efficiency and quality control. These tests were performed to compare their efficiencies among preparations with same active ingredient and its amount. Those were used as a method in measuring bioavailability of each product. The materials were four famotidine tablets which were made in four different manufacturers (A, B, C and D). The results were as follows. 1) The Dissolution Test was performed for an hour using Paddle method, in the solution of pH 4.5 and artificial gastric juice. D_(30) min(Dissolution rates for 30 minutes) of A, C and D products were more than 75%, but the one of B product was much less. 2) In the Content Uniformity Test, all the contents of products(A, B, C and D) were more than 90%. As a result, although the contents of all products were the same, the dissolution rates of B product was not equivalent to A, C and D products. In conclusion, the dissolution rate is one of major factors which can affect the bioavailability of products. It is recommended that the Dissolution Test be disseminated as a method in comparing the bioavailability of each product.
Etoposide의 혼합조제시 희석농도와 시간에 따른 안정성 실험
김옥녀,김운학,이나영 한국병원약사회 1997 병원약사회지 Vol.14 No.4
Etoposide is semisynthetic podophyllotoxin-derivative antineoplastic agent. It has low aqueous solubility and precipitation occurs irregularly and unpredictably. Manufacturer recommends that etoposide should be used below concentration of 400 ㎍/㎖. Aqueous solutions of etoposide in two diluents (5% dextrose water and normal saline) up to 400 ㎍/㎖ are stable up to 24 hours at 25℃. However, precipitation has been reported occasionally in shorter time period in our hospital. We studied the stability of etoposide in different concentration by time course. Etoposide(Vepesid®) was diluted in 5% dextrose water and normal saline at 300, 350 and 400 ㎍/㎖. Physical change was checked by visual and aqueous etoposide samples were collected for HPLC analysis with 0, 3, 6, 10, 24, 48 hour after diluting. A diluted USP etoposide reference standard (350 ㎍/㎖) was used as a standard solutions. The results are as following: 1) At concentration 300 ㎍/㎖, the aqueous solution of etoposide was visually stable for 24 hours. 2) At concentration 350 and 400 ㎍/㎖, there was no change for 10 hours, but precipitation and potency loss were observed for 24 hours. 3) There was no significant difference between diluents for the stability of etoposide.