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사염화탄소로 유발한 흰쥐의 간독성에 대한 Silymarin과 Biphenyl Dimethylene Dicarboxylate 및 그 혼합 투여시의 억제 효과
김옥경,이은방,Kim, Ock-Kyung,Lee, Eun-Bang 한국생약학회 1998 생약학회지 Vol.29 No.2
The increased AST and ALT activities of rat serum disturbed by $CCl_4-intoxication$ intoxication were significantly inhibited by silymarin and biphenyl dimethylene dicarboxylate at the oral doses of 150 and 5 mg/kg, respectively. The combined administration of the drugs showed remarkable inhibition of the enzyme activities. This fact may suggest that the two drugs have potentiative action in this experiment.
재조합 인간 상피세포 성장인자(DWP 401)의 흰쥐 위액분비 및 궤양에의 작용
이은방(Eun Bang Lee),천선아(Seon Ah Cheon),이은심(Eun Shim Lee),김옥경(Ock Kyung Kim) 대한약학회 1996 약학회지 Vol.40 No.4
The effects of human epidermal growth factor(EGF) which was produced by recombinant DNA technique was investigated on gastric secretion, gastric lesion and ulcer models in rats. The EGF showed significant inhibition of secretion of gastric juice and total acid output, at 0.4mg/kg, id and also inhibited Shay ulceration at 0.4mg/kg, id in rats. The lesion induced by absolute ethanol was significantly reduced by oral administration of EGF at 0.4mg/kg. Likewise, EGF caused significant inhibition of indomethacin induced gastric ulcer at oral doses of 0.2 and 0.4mg/kg. The EGF produced dose-dependent inhibition of gastric ulcer induced by acidified aspirin, but showed no significant inhibition at oral doses of 0.1, 0.2 and 0.4mg/kg. The chronic gastric ulcer induced by injection of 20% acetic acid solution was significantly reduced by oral doses of 0.1 and 0.4mg/kg of EGF. Duodenal ulcer induced by mepirizole was dose-dependently inhibited by oral doses of 0.1, 0.2 and 0.4mg/kg of EGF. These data suggest that EGF possesses pronounced inhibitory action in gastric ulcer and duodenal ulcer of rats.