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항코린에스테라제 독성에 대한 Histamine길항제의 효과
박은희,양근해,김오션 숙명여자대학교 약학연구소 1997 약학논문집-숙명여자대학교 Vol.13 No.-
This study was designed to examine the effects of antihistamines on the toxicity of neostigmine, a reversible cholinesterase inhibitor, in mice. Diphenhydramine and promethazine pretreatment increased the LD_(50) value of neostigmine by 2.15- and 3.65-fold, respectively. They also increased the onset times of toxic manifestations such as whole body tremor, loss of righting reflex and death. However, chlorcyclizine, chlorpromazine, i antazoline, chlorpheniramine and cimetidine pretreatment did not reduce the toxicities of neo-stigmine.