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가정의학과 외래 우울증환자에서 moclobemide의 안전성 및 유효성 평가를 위한 시판후조사
김영식,이근미,김병성,신호철,성은주,이상엽,문유선,송상욱,김철환,선우성,Kim, Young-Sik,Lee, Keun-Mi,Kim, Byung-Sung,Shin, Ho-Cheol,Sung, Eun-Ju,Lee, Sang-Yeoup,Moon, Yoo-Sun,Song, Sang-Wook,Kim, Cheol-Hwan,Sunwoo, Sung 대한임상약리학회 2002 臨床藥理學會誌 Vol.10 No.1
Background : Depression is quite a common disease in primary care however, studies for the safety and effectiveness of antidepressants in primary care setting are rare in Korea. Objectives : This multi-centered post-marketing study was performed to evaluate the safety and effectiveness of Moclobemide and to find out the factors related to the adherence among patients with depression in family practice. Methods : A total of 386 patients were enrolled from July 1999 to January 2000 by twenty family doctors from fifteen family practice centers. They were prescribed Moclobemide and were reevaluated at the 4th, 8th, and l2th week. Evaluation of compliance, safety and effectiveness were performed with pre-made, structured self-reported questionnaires. Evaluation of effectiveness was also performed utilizing self-rating depression scale (SDS). Results : Among 386 patients, safety was evaluated in 310 patients and effectiveness was evaluated in 239 patients. During the first 12 weeks, the number of subjects continuing with Mocclobemide was 136(37.1%). 141 subjects (38.4%) discontinued taking the drug and 90 subjects (24.5%) dropped out at the 12th week. Considering drop-out patients as ineffective cases, overall effectiveness was estimated to be 84.5%. Symptoms improved with time in patients whose follow-up were completed (P<0.01). The SDS score decreased by an average of ${6.8{\pm}9.1(12.2{\pm}19.1%)}$ after 12 weeks(p<0.01). During the study, 33(10.6%) subjects reported adverse events. The most commonly reported adverse events, in descending order, were dizziness(2.3%), headache(1.6%), insomnia(1.3%), facial edema(1.3%), constipation(1.0%), nausea(1.0%) and tremor(1.0%). The main reasons for discontinuing antidepressants were attributed to improvement of symptoms and manifestation of adverse events. Conclusion : The percentage of adherence at 12th week of Moclobemire among patients suffering from depression in the family practice outpatient clinic was shown to be 49%. The antidepressant effect and safety of Moclobemide was relatively superior.
레토르트 및 감마선 조사에 의한 화닭 덮밥 소스의 미생물 제어 효과 비교
김영식,김현주,윤요한,신명곤,김천제,신미혜,이주운,Kim, Young-Sik,Kim, Hyun-Joo,Yoon, Yo-Han,Shin, Myung-Gon,Kim, Cheon-Jei,Shin, Mee-Hye,Lee, Ju-Woon 한국축산식품학회 2010 한국축산식품학회지 Vol.30 No.1
This study evaluated the antimicrobial effects of retort process and gamma irradiation on reduction of total bacterial populations in spicy chicken sauce, which is served on top of the steamed rice. Commercial spicy chicken sauce was treated with retort and gamma ray at 0, 1, 3, 5, and 10 kGy. Total aerobic bacterial populations were then enumerated on plate count agar and isolated bacteria from the test samples were identified using PCR analysis. Moreover, gamma ray sensitivity of identified bacteria was evaluated by $D_{10}$ values, and genotoxicity of gamma-irradiated samples was examined. Gamma irradiation at 3 kGy reduced total aerobic bacterial cell counts in spicy chicken sauce below detection limit, but total aerobic bacterial cell counts in test samples treated with retort were 2.1 log CFU/g. Identified bacteria from the samples were Bacillus subtilis, B. amyloiquefaciense, and B. pumils, and the $D_{10}$ values for B. subtilis and B. cereus were 0.39 ($R^2\;=\;0.921$) and 0.28 log CFU/g ($R^2\;=\;0.904$), respectively. The SOS chromotest showed that the gamma-irradiated spicy chicken sauce did not cause mutagenicity. These results indicate that gamma irradiation of spicy chicken sauce could be useful in ensuring microbial safety.
초내열합금분말에 의한 PTA 오버레이부의 연삭 마모 특성 연구
김영식,최영국,임창훈,김종도,Kim, Young-Sik,Choi, Young-Gook,Lim, Chang-Hoon,Kim, Jong-Do 대한용접접합학회 2009 대한용접·접합학회지 Vol.27 No.3
The Plasma Transferred Arc (PTA) overlay welding method is lately introduced as one of the most useful surface overlay method of the engine component. In this paper, the overlay welding on the SNCrW heat resisting alloy was conducted by the PTA overlay welding process using the super alloy powder. The characteristics of the overlay layers were investigated through the metallurgical and abrasive test. Experimental results showed that the overlay on the SNCrW heat resisting alloy surface was successfully made without hot cracking. The friction wear characteristics of the Co-base Stellite 6 overlayer were most superior. However the abrasive wear characteristics were most inferior in the Co-base Stellite 6 overlayer.
김영식,Kim Young-Sik 한국환경보건학회 2004 한국환경보건학회지 Vol.30 No.5
In this study, lots of methods have been studing to utilize energy and decrease contaminated effluents. There has been great progress on IGCC (Integrated gasification combined cycle) to reduce thermal energy losses. The following results have been conducted from desulfurization experiments using waste shell to remove $H_{2}S$. Unreacted core model ior desulfuriration rate prediction of sorbent was indicated. These were linear relationship between time and conversion. So co-current diffusion resistance was conducted reaction rate controlling step. The sulfidation rate is likely to be controlled primarily by countercurrent diffusion through the product layer of calcium sulfide(CaS) formed. Maximum desulfurization capacity was observed at 0.631 mm for lime, oyster and hard-shelled mussel. The kinetics of the sorption of $H_{2}S$ by CaO is sensitive to the reaction temperature and particle size at $800^{\circ}C$, and the reaction rate of oyster was faster than the calcined limestone at $700^{\circ}C$.
김영식,장성수,이선영,진원혁,조일주,남효진,부종욱,Kim Young-Sik,Jang Seong-Soo,Lee Caroline Sun-Young,Jin Won-Hyeog,Cho Il-Joo,Nam Hyo-Jin,Bu Jong-Uk 정보저장시스템학회 2006 정보저장시스템학회논문집 Vol.2 No.2
In this research, a wafer-level transfer method of cantilever away on a conventional CMOS circuit has been developed for high density probe-based data storage. The transferred cantilevers were silicon nitride ($Si_3N_4$) cantilevers integrated with poly silicon heaters and piezoelectric sensors, called thermo-piezoelectric $Si_3N_4$ cantilevers. In this process, we did not use a SOI wafer but a conventional p-type wafer for the fabrication of the thermo-piezoelectric $Si_3N_4$ cantilever arrays. Furthermore, we have developed a very simple transfer process, requiring only one step of cantilever transfer process for the integration of the CMOS wafer and cantilevers. Using this process, we have fabricated a single thermo-piezoelectric $Si_3N_4$ cantilever, and recorded 65nm data bits on a PMMA film and confirmed a charge signal at 5nm of cantilever deflection. And we have successfully applied this method to transfer 34 by 34 thermo-piezoelectric $Si_3N_4$ cantilever arrays on a CMOS wafer. We obtained reading signals from one of the cantilevers.