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견관절의 화농성 및 결핵성 복합 관절염의 관절경적 치료 - 증례보고 -
고상봉,김신근,최원기,박재현,최창혁,Ko, Sang-Bong,Kim, Shin-Keun,Choi, Won-Kee,Park, Jae-Hyun,Choi, Chang-Hyuk 대한관절경학회 2008 대한관절경학회지 Vol.12 No.2
결핵은 새로운 항결핵제의 개발, 생활 여건의 향상, 예방 대책의 발달로 유병률이 적어진 질환으로 알려지고 있으나, 최근 예방 접종률의 저하와 항결핵제에 내성을 보이는 균주가 출연하는 등 다시 증가하는 추세이며 또한, 견관절 질환에 대한 관심이 높아지며 일차 치료로써 다양한 견관절내 주사 치료가 시행되면서 화농성 견관절염 역시 증가하는 추세이다. 이에 저자들은 견관절의 결핵과 화농성 관절염이 동반 감염된 증례를 경험하여 만족할 만한 결과를 얻었기에, 관련 문헌과 함께 보고하는 바이다. Although the incidence of tuberculosis has been decreased due to new anti-tuberculous agents, improved socioeconomic status and development of multimodal preventive methods, in recent that is increased due to low vaccination rate and appearance of multidrug resistence organism. And the incidence of pyogenic shoulder joint arthritis is increasing due to frequent injection therapy as primary treatment. We have managed the mixed shoulder joint arthritis-pyogenic and tuberculous-with arthroscopic debridement and antituberculous medication successfully and then we report this case with relevant literatures.
병태동물(病態動物)에서의 약물(藥物)의 Hepatic Clearance에 관한 연구(硏究) I -병태가토(病態家兎)에서의 Bromphenol Blue의 간담수송(肝膽輸送)-
우종학,김신근,이민화,한건,Woo, Chong-Hak,Kim, Shin-Keun,Lee, Min-Hwa,Han, Kun 한국약제학회 1980 Journal of Pharmaceutical Investigation Vol.10 No.1
Bromphenol blue (BPB) was studied with rabbits in normal and disease states to understand the basic principles of hepato-biliary transport process, and the effect of disease states on the drug disposition. The time course of plasma concentration and of biliary excretion was studied in normal and $CCl_4$ intoxicated rabbits. A conspicuous retention of BPB clearance from the plasma was observed, and the slope of the first-phase of plasma curve was decreased in the intoxicated rabbits. The shape of biliary excretion was same in normal and intoxicated states, but the amount of BPB excreted into bile in the intoxicated states was much smaller than in normal states. A relationship was found which enables one to predict the pattern of uptake of BPB by the liver, and the pattern of excretion into the bile in normal states, but was not in $CCl_4$ intoxicated states. It may be that the application of this experiments would extend the effect of disease states on the drug disposition.
雙和湯이 四鹽化炭素에 의한 肝障害 Rat에서 Sulfobromophthalein의 體內動態에 미치는 영향
안병락,김신근,심창구,정연복,Ann, Byung-Nak,Kim, Shin-Keun,Shim, Chang-Koo,Chung, Youn-Bok 대한약학회 1984 약학회지 Vol.28 No.4
Effects of Ssang Wha Tang (SWT), a blended Chinease traditional medicine, on the pharmacokinetics of sulfobromophthalein (BSP) in the rats of hepatic failure induced by carbon tetrachloride were examined. The disposition of plasma BSP in carbon tetrachloride-treated rats (Group I) and in carbon tetrachloride+SWT-treated rats (Group II) followed a three-compartment model, while those in control group followed two-compartment model. GOT, GPT level and some pharmacokinetic paramiters like plasma clearance but except distribution volume (Vdss) recovered in Group II compared to Group I. Therefore, SWT seemed to have an apparent restoring effect of hepatic function damaged by carbon tetrachloride treatment. From the fact that Vdss of BSP in Group II was considered as an one of the probable mechanisms. More intensive increase in BSP-free fraction ($f_p$) in Group II than that in Group I might also explain the increases of BSP clearance and Vdss in Group II compared to Group I. Assuming no changes in hepatic plasma flow(Q) in each group, hepatic intrinsic clearance($CL^h_{int}$) decreased in Group I did not recovered not at all in Group II. Therefore SWT seemed not to have any restoring effect of true hepaticfunction to biotransform and excrete BSP, and the apparent restoring effect of SWT might be due only to the replacement of BSP-plasma protein binding. Whether $f_p$ is actually higer in Group II than in Group I, and Q is constant in each group are being examined in our laboratory. The changes of Q, which might lead to another conculusions, also should be taken into consideration to clarify the apparent hepatorestoring effect of SWT.
Knee Arthroscopy in the Obese: A Case Report
백승훈,김신근,Baek, Seung-Hoon,Kim, Shin-Keun Korean Arthroscopy Society 2010 대한관절경학회지 Vol.14 No.1
비만환자에서 유용한 수술적 술기와 증가된 술전 및 술후 위험성에 대한 보고들은 있으나, 비만이 관절경적 시술에 미치는 영향에 대한 보고는 거의 없는 실정이다. 저자들은 체중 120kg의 17세 남자환자에서 반월상연골 부분절제술을 시행한 후, 현재까지 출간된 문헌들을 고찰하고 비만환자들에서 슬관절 관절경술 시행시 발생할 수 있는 합병증과 수술적 술기에 대한 정보를 제공하고자 한다. Several reports have described the increased perioperative risks as well as surgical techniques for performing various procedures in obese patients. However, few reports have addressed the effects of obesity on routine arthroscopic procedures known to be common and safe. Describing the case of a partial meniscectomy performed in a 17-year-old male with a body weight of 120 kg, we review literatures published to the present and provide technical problems and possible complications that can occur when performing routine knee arthroscopy in bariatric patients.
전인구,이민화,김신근,Jeon, In-Koo,Lee, Min-Hwa,Kim, Shin-Keun The Korean Society of Pharmaceutical Sciences and 1976 Journal of Pharmaceutical Investigation Vol.6 No.3
It is well established that dissolution is freruently the rate limiting step in the gastrointestinal absorpton of a drug from a solid dosage from. The relationship between the dissolution rate and absorption is particularly distinct when considering drugs of low solubility. Consequently, numerous attempts have been made to modify the dissolution characteristics of poorly water soluble drugs. Since dissolution rate is directly proportional to surface area, one may increase the rate by decreasing the particle size of the drug. Levy has considered a number of methods by which a drug may be presented to the GI fludids in finely divided from. The direct method is the utilization of microcrystalline or micronized particles. A second method involves the administration of solutions from which, upon dilution with gastric fluids, the dissolved drug will precipitate in the form of very fine particles. A more unique way of obtaining microcrystalline dispersions of a drug has been ercently suggested by Sekiguchi et al. They have first proposed the formation of a eutectic mixture of a poorly water soruble drug with a physiologically inert, easily soluble carrier. When such systems are exposed to water or GI fluids, the soluble carrier will dissolve rapidly and the finely dispersed drug particles will then be released. It has been suggested by Shefter and Higuchi that the formation of crystalline solvate could be a powerful tool in affecting rapid disslution of highly insoluble substances. Goldberg et al. have noted that the formation of solid solution could reduce the particle size to a minimum and increase the dissolution rate as well as the solubility of the durgs. It has also been shown that the rates of solution of drugs were appreciably increased by coprectipitating the drug with soluble polymers. The increase was found to be sensitive to the method of preparation, the molecular weight of polymer and the particular ratio of drugs to polymer. Although several investigations have demontrated that the solubility and/or dissolution rates of drugs can be increased in this manner, little information is available in the literature related to the in vivo absorption pattern of drugs orally administered as PVP coprecipitates. Recently, however, it was demonstrated that both the rate and extent of absorption of the insoluble drug could be markedly enhanced when orally administered to rats in the form of a coprecipitate with PVP. The purpose of the present investigation was to ascertain the general appility of soluble polymer coprectation technique as a method for enhancing the in vitro dissolution rate of hydrophobic indomethacin. To accomplish this aim, the dissolution characteristics of pure indomethacin, indomethcin-polymer physical mixtures and indomethacin-polymer coprecipitates were quantitatively studied by comparing their relative dissolution rates. The solubility and dissolution behavior of these systems were also examined.
수용성 폴리파라시클로판류와 약물과의 상호작용 (제1보) -디페닐에텔을 골격으로 하는 수용성 폴리파라시클로판류의 설계 및 합성-
전인구,이민화,김신근,Chun, In-Koo,Lee, Min-Hwa,Kim, Shin-Keun 한국약제학회 1988 Journal of Pharmaceutical Investigation Vol.18 No.2
A series of novel water-soluble paracyclophanes containing two diphenyl ether skeletons and two bridging aliphatic chains of various length were designed and prepared to develop artificial host compounds which might provide efficient hydrophobic field. They were 1,5,19,23-tetraaza-12,30-dioxa[5,1.5.1] paracyclophane (6), 1,6,20,25-tetraaza-13,32-dioxa[6.1.6.1]paracyclophane (7), 1,7,21,27-tetraaza-14,34-dioxa[7.1.7.1]paracyclophane (8) and 1,8,22,29-tetraaza-15,36-dioxa[8.1.8.1]paracyclophane (9). As the corresponding acyclic analogue, 4,4'-dimethylaminodiphenyl ether (11) was synthesized for the comparative study of further host-guest interaction.
한건,이민화,김신근,Han, Kun,Lee, Min-Hwa,Kim, Shin-Keun 한국약제학회 1984 Journal of Pharmaceutical Investigation Vol.14 No.1
The pharmaceutical characteristics of solid indoprofen inclusion complex such as dissolution, permeation through a cellophane membrane, model analysis of interfacial tranesfer, absorption behaviors in rat intestine, and the plasma concentration of indoprofen after oral administrations to rabbits were examined in comparison with those indoprofen alone. The inclusion complex obtained by freeze-drying method showed the higher dissolution rate and membrane permeability among the test powders, and increased significantly the amont of indoprofen absorbed in rat intestine and the levels of plasma concentration of indoprofen after oral adminstrations to rabbits. The increase of bioavailability of $indoprofen-{\beta}-cyclodextrin$ complex was considered due to the increased solubility and dissolution rate of solid powder form.
수용성 폴리파라시클로판류와 약물과의 상호작용(제 2보) -수용액중 수용성 폴리파라시클로판류와 형광 소수 나프탈렌 유도체류와의 상호 작용-
전인구,이민화,김신근,Chun, In-Koo,Lee, Min-Hwa,Kim, Shin-Keun 한국약제학회 1988 Journal of Pharmaceutical Investigation Vol.18 No.3
A series of water-soluble polyparacyclophanes bearing two diphenylmethane or two diphenyl ether skeletons were investigated to develop useful host compounds by using 1-anilinonaphthalene-6-sulfonate (ANS) and 2-p-toluidinylnaphthalene-6-sulfonate (TNS) as fluorescent hydrophobic substrates in aqueous solution. It was noteworthy that remarkable fluorescent enhancements and blue shifts of ANS and TNS were observed only in the presence of 1,6,20,25-tetraaza[6.1.6.1] paracyclophane (CPM 44) and 1,6,21,27-tetraaza [7.1.7.1] paracyclophane (CPM 55) for diphenylmethane skeleton, and 1,7,21,27-tetraaza-14,34-dioxa [7.1.7.1] paracyclophane (CPE 55) and 1,8,22,29-tetraaza-15,36-dioxa [8.1.8.1] paracyclophane (CPE 66) for diphenyl ether skeleton, comparing with ${\alpha}-\;and\;{\beta}-cyclodextrins$. However, their acyclic analogues such as 4,4'-dimethylaminodiphenylmethane and 4,4'-dimethylaminodiphenyl ether, and paracyclophanes whose cavities were smaller showed only small effects under the same conditions. These facts suggested that hosts and substrates were in an intimate contact which would not occur without larger structures, and thus that guest molecules were strongly incorporated in the hydrophobic cavities of these larger paracyclophanes. The effects of pH on the fluorescent intensity of ANS-CPM 44, ANS-CPM 55, ANS-CPE 55, ANS-CPE 66, TNS-CPM 44, TNS-CPM 55, TNS-CPE 55 and TNS-CPE 66 systems were not significant below pH 2.0, but their fluorescent intensities were markedly reduced with increasing ionic strength.