눈운동장애 없이 시력 저하를 보인 해면정맥동 내경동맥류 1예

김승훈,김선웅,김범태,장지호,Seung Hoon Kim,Sun Woong Kim,Bum-Tae Kim,Jee Ho Chang 대한안과학회 2012 대한안과학회지 Vol.53 No.3

Purpose: Oculomotor disturbance is the common manifestation of intracavernous carotid aneurysm cases. Intracavernous carotid aneurysms causing compressive optic neuropathy with no oculomotor disturbance are relatively rare due to their anatomical characteristics. We experienced a case of intracavernous carotid aneurysm which resulted in a shifted supraclinoid segment of the internal carotid artery, presenting with visual loss and visual field defect with no oculomotor disturbance. Case summary: A 40-year-old woman presented with loss of vision in the right eye. A relative afferent pupillary defect was observed in this eye. Visual field test showed quadranopsia in the right eye. Magnetic resonance imaging revealed that the intracavernous carotid aneurysm had shifted the supraclinoid segment of the internal carotid artery to the superomedial position. The right optic nerve was directly molded by the shifted supraclinoid segment of the internal carotid artery at the point of the bifurcation between the anterior cerebral artery and the middle cerebral artery. A Guglielmi detachable coil (GDC) embolization was performed successfully with no operational complications. Six months after coiling, best corrected visual acuity of the right eye was 1.0, and the visual field defect had recovered in all except the superior temporal field. Conclusions: Oculomotor disturbance is frequently associated with intracavernous carotid aneurysms. Nevertheless, optic neuropathy without oculomotor disturbance may be the only sign in patients with an intracavernous carotid aneurysm that causes shifting of the supraclinoid segment of the internal carotid artery. J Korean Ophthalmol Soc 2012;53(3):486-491

스펙트럼 영역 빛간섭단층촬영기를 이용한 근시 정도에 따른 황반 구조의 정량적 분석

김승훈,박주연,박태관,온영훈,Seung Hoon Kim,Joo Youn Park,Tae Kwann Park,Young-Hoon Ohn 대한안과학회 2011 대한안과학회지 Vol.52 No.11

Purpose: To investigate the correlation of macular retinal thickness and refractive error using spectral-domain optical coherence tomography (SD-OCT). Methods: A total of 120 eyes with no posterior abnormalities were enrolled in the present study. Subjects were divided into 3 groups based on their spherical equivalent. Visual acuity, refraction, slit lamp examination, tonometry and fundus examination were performed. Retinal thickness between the RPE and IS/OS junction was measured at the fovea, 1 mm (inner ring) and 2 mm (outer ring) superiorly, inferiorly, nasally and temporally using SD-OCT. Overall average thickness, average foveal thickness, and the inner and outer ring macular thickness were measured. Results: The average foveal thickness was significantly greater in the high myopic eyes than in the low to moderate myopic and emmetropic eyes (p = 0.001). However, the RPE-IS/OS junction thickness of the foveola and the outer macular thickness were significantly lower (p = 0.001, p = 0.002) in the high myopic eyes. There was a weak, but significant negative correlation between refractive error and average foveal thickness (r = -0.38, p = 0.001). A positive correlation was found between refractive error and the RPE-IS/OS junction thickness (r = 0.40, p = 0.001). Conclusions: Macular retinal thickness is related to refractive error in normal subjects. Effects of eyeball elongation are more apparent in high myopic eyes than in low to moderate myopic eyes. A significant decline in the RPE-IS/OS junction thickness suggests the photoreceptor outer segments in the foveola are damaged in high myopic eyes. J Korean Ophthalmol Soc 2011;52(11):1286-1295

$(HF)_2(CO)$ 분자착물에 관한 Ab Initio 연구

김승훈,Kim, Seung Hoon 대한화학회 1998 대한화학회지 Vol.42 No.6

$6-31+G^{\ast}^{\ast}와\;6-311+G^{\ast}^{\ast}$의 기본조를 사용해서 이합체 분자착물 FH…FH, FH…CO, FH…OC 뿐만 아니라 $(HF)_2(CO)$의 형성가능한 두가지 삼합체 분자착물들에 대해서 HF-SCF, MP2 그리고 B3LYP 계산을 수행했다. 이 삼합체 분자착물들에 대한 여러 가지 바닥상태 성질들을 구하였으며, 대응하는 단위체들과 이합체들의 성질들과 비교하였다. FH…CO가 FH…OC에 비해 평균 0.85 kcal/mol 만큼 안정했고, F-H…F-H…C≡O가 F-H…F-H…O≡C 보다 1∼2 kcal/mol 만큼 안정한 것으로 계산되었다. 삼합체 분자착물 형성에 따른 C≡O stretching band 는 그들의 이합체들(FH…CO, FH…OC)에 비해 각각 24, $37\;cm^{-1}$만큼, H-F stretching band는 각각 $54, 353\; cm^{-1}$만큼 red shift 되는 것으로 평가되었다. The HF-SCF, MP2 and B3LYP calculations have been performed on the two conceivable clusters $(HF)_2(CO)$ trimers as well as their dimer complexes FH…FH, FH…CO and FH…OC applying $6-31+G^{\ast}^{\ast}$, and $6-311+G^{\ast}^{\ast}$ basis sets. A variety of ground state properties of these trimer complexes have been listed, and compared with corresponding properties of isolated monomers and combined dimers. It was calculated that FH…CO is more stable than FH…OC by average 0.85 kcal/mol and F-H…F-H…C≡O is more stable than F-H…F-H…O≡C by 1-2 kcal/mol. The C≡O stretching bands of the F-H…F-H…C≡O and F-H…F-H…O≡C were red shifted by 24, $37\;cm^{-1}$ compared with the FH…CO and FH…OC respectively. Also, H-F stretching bands were red shifted by 54 and $353\;cm^{-1}$.

마이크로파를 이용한 급속 가열 연신 공정의 동역학 모델링과 정상상태 특성 해석

김승훈,백영남,허유,Kim, Seung-Hoon,Paik, Yeong-Nam,Huh, You 한국섬유공학회 2006 한국섬유공학회지 Vol.43 No.6

Fiber forming is an important technology for producing multi-functional goods that have a flexible and structured plane form by using raw material with special properties. This research reports on the metal fiber manufacturing technology that adopted induction heating and drawing, but without use of dies that are now installed in the conventional wire drawing processes. Heating wires allows the drawing process to build up necking and to shorten the process by reducing the process steps so that a new and efficient production method of metal fibers is to be conceived and developed. A new device that can process a single wire consists of three major parts: the drawing part comprised of capstans, that is, feeding roll and take-up roll with specially hardened circumferential surface, the change gear part with continuously controllable draw ratio, and the heating part that includes a heating source and an energy propagation channel and an electromagnetic wave absorber With this device feasibility of the induction heating method is tested and the characteristics of the metal wire drawing process is analyzed. Results show that the microwave can be applied to attenuate the metal wire as a heating source and the experimental profiles of the cross-sectional area in the heated drawing zone under a steady state condition coincide well with those from theoretical model. The diametric variation of the drawn wires increased, however, as the drawing ratio increased.

류마티스 관절염 환자에서 Conserved T 세포 수용체의 CDR3 motif를 표현하는 제2형 콜라겐 특이 T세포주의 형성과 유지

김승훈,조미라,윤지희,박성환,조철수,황수연,김호연,Kim, Seung-Hoon,Cho, Mi-La,Youn, Jeehee,Park, Sung-Hwan,Hwang, Sue-Yun,Cho, Chul-Soo,Kim, Ho-Youn 대한면역학회 2001 Immune Network Vol.1 No.1

Background: To determine the molecular structure of type II collagen-specific T-cell receptors associated with rheumatoid arthritis (RA). Methods: We generated CII-specific T-cell lines of 8 RA patients by prolonged in vitro culture with bovine CII (bCII) and the immunogenic peptide (256-270) of human CII. The proliferation response towards CII stimulation was measured from the uptake of 3H-thymidine. Changes in the secretion of Th 1 and Th2 cytokines in the culture supernatent were measured by ELISA. The TCR clonotypes of these T-cells were examined by RT-PCR/SSCP analyses of all 22 $V_{\beta}$ chains. Results: T-cells from patients' tissue exhibited strong proliferation index upon CII stimulation, which was maintained up to 6 months in the culture. The secretion of INF-$\gamma$from these T-cells increased along with the duration of culture time, while the amount of IL-4 production did not show significant changes. The SSCP band patterns of patients' T-cells appear as discrete bands unlike the smeary streak produced from normal samples. Some SSCP bands, each representing selected expansion of a TCR containing certain subtype of $V_{\beta}$ peptides, appeared to be identical in more than one patients. Among these, the expansion of SSCP band representing the $V_{\beta}$ 14 CDR3 region persisted after switching the antigen to the immunogenic human peptide (256-270). Conclusion: CII-reactive T-cells expressing distinct CDR3 motifs are selectively expanded in the peripheral blood and synovial fluid of RA patients, and their persistent proliferation upon CII stimulation, as well as the production Th 1-type cytokines, may play pivotal roles in RA pathogenesis.

정시안에서 스펙트럼영역 빛간섭단층촬영기를 이용한 연령과 성별에 따른 황반 두께의 변화

김승훈,최경식,이성진,Seung Hoon Kim,Kyung Seek Choi,Sung Jin Lee 대한안과학회 2011 대한안과학회지 Vol.52 No.3

Purpose: To evaluate the changes in macular thickness with regard to age and gender in normal subjects with emmetropia using spectral domain optical coherence tomography. Methods: The present study consisted of 90 healthy subjects (162 eyes) with no ophthalmic evidence of retinopathy and who had emmetropic eyes. The data from macular measurements using spectral domain optical coherence tomography was analyzed according to the groups divided by age (Group 1: 0 to 19 years of age, Group 2: 20 to 39 years of age, Group 3: 40 to 59 years of age, Group 4: 60 to 80 years of age) and gender. Results: Macular thickness of the central circle was 253.40 ± 23.03 μm in all subjects. There was no significant change with age (p > 0.05). However, the measurements at the inner (3 mm) and outer circle (6 mm) showed a reduction of macular thickness with age (p < 0.05). The macular thickness at the central and inner circle was significantly lower in the female subjects (p < 0.05). In group 3 and 4, macular thickness at the central circle in males was greater than in females. In group 3, the average inner macular thickness in males was significantly greater than in females (p < 0.05). Conclusions: In normal subjects with emmetropia, there are statistically significant differences in macular thickness between subjects of different age and gender. The results from the present study can be expected to provide a reference value for evaluating macular disease. J Korean Ophthalmol Soc 2011;52(3):299-307

가족복지를 위한 남북이산가족상봉

김승훈(Seung-Hoon Kim) 大韓赤十字社 人道法硏究所 2005 人道法論叢 Vol.- No.25

가족은 인류역사에 있어서 모든 제도 중 가장 끈질기고 강력한 제도로서 인간의 양육 및 성장과 함께 가족 구성원의 생물학적 생존과 재생산, 사회화 기능을 담당하고 있다. 복지국가를 지향하고 있는 우리나라에서는 ‘모든 국민은 인간다운 생활을 할 권리를 가진다’라고 헌법에 명시하고 있으며, 이것은 복지사회의 기초 단위인 가족의 행복을 위해서 이산가족문제를 해결하고자 하는 이유가 되는 것이다. 그러나 남과 북의 특수한 상황을 고려하여 볼 때 이러한 노력에는 일방적인 주장보다는 당위성과 법률적 근거가 있어야 한다. 이것은 크게 직접적 근거와 간접적 근거로 대별할 수 있는데, 직접적 근거에는 남북 사이의 화해와 불가침 및 교류 · 협력에 관한 합의서와 이에 대한 부속서가 있으며 간접적 근거에는 국제연합 헌장, 세계인권선언, 제네바협약, 7 · 4남북공동성명, 국제적십자회의의 결의, 휴전협정, 남북조절위원회 합의서 등이 있다. 이러한 여러 가지의 근거에도 불구하고 이에 대하여 의무적 이행을 강제할 수 없기 때문에 이산가족상봉의 어려움이 따르고 있는 것이다. 이에 본 연구는 이산가족의 상봉이나 교류 자체를 목적으로 보기 보다는 가족 기능의 회복을 향해 가는 과정으로 파악하였다. 남북이산가족이 서로 만나고 재결합을 이루거나 또는 재결합을 이루지 못한 채 가족의 회복 또는 가족의 정상화를 위해 나가는 과정에 국민적 관심이 증대되기를 바란다. 더욱이 이러한 국민적 관심속에서 이산가족의 고통을 경감하는데 우리 민족은 물론 국제적 공감대 형성과 북한 측의 성의 있는 자세를 다시 한번 촉구하는 바이다. Family, the most persistent and steadfast system among all systems existing in human history, is playing the roles of raising and developing humans as well as preserving, reproducing and socializing the family members. In Korea as a country pursing a welfare state, the Constitution declares that 'All people reserve the right to live a decent life.' This is why the problem of separated families must be solved for the happiness of families, which are the basic unit of welfare society. Considering the special situation of South and North Korea. however, such an effort must not be an one-sided insistence but be supported by sound legal grounds. Such grounds are largely divided into direct and indirect ones. Direct grounds include the Agreement on Reconciliation, Nonaggression, Exchange and Cooperation between South and North Korea and its annexed documents, and indirect ones include the United Nations Charter, Universal Declaration of Human Rights, the Geneva Conventions, 7/4 South-North Korea Joint Declaration, the Resolution of International Conference of the Red Cross and Red Crescent, the Armistice Agreement, the Agreement of the South-North Coordinating Committee, etc. Despite these grounds, however, the reunion of separated families cannot be forced as an obligation. Thus the present study understood the reunion of separated families or exchange between them as a process toward the restoration of the family functions rather than as a goal. It is necessary for people to take more interest in the process of restoring or normalizing families with or without the reunion of separated families in South and North Korea. Thus the author urges that, in addition to our efforts, there must be international consensus and North Korea's sincere attitude to reduce separated families' pains.

사내근로복지기금이 성장성과 노동생산성에 미치는 영향 : KOSPI 200 제조기업

김승훈 ( Seung-hoon Kim ),윤병섭 ( Byung-seop Yoon ) 한국금융공학회 2020 금융공학연구 Vol.19 No.1

본 연구는 2002년부터 2018년까지 17년 동안 KOSPI 200 제조기업 159개를 대상으로 사내근로복지기금을 형성한 기업 87개와 사내근로복지기금을 형성하지 않은 기업 72개로 양분하여 사내근로복지기금이 성장성과 노동생산성 등 재무성과에 미치는 영향을 분석하였다. 실증분석 결과는 다음과 같다. 첫째, 사내근로복지기금을 형성한 기업이 고정효과에서 성장성인 매출액 증가율에 유의한 양(+)의 영향을 미치고 있음을 발견하였다. 둘째, 사내근로복지기금을 형성한 기업이 고정효과에서 노동생산성인 종업원 1인당 매출액 증가율에 유의한 양(+)의 영향을 미치고 있음을 발견하였다. 셋째, 사내근로복지기금을 형성한 기업이 고정효과에서 노동생산성인 종업원 1인당 부가가치생산성 증가율에 유의한 양(+)의 영향을 미치고 있음을 발견하였다. 넷째, 사내근로복지기금 기본자산 총액 변수, 경제성장률의 대용변수로 사용한 전년 대비 GDP 증가율 등이 매출액 증가율, 종업원 1인당 매출액 증가율, 종업원 1인당 부가가치생산성 증가율에 각각 체계적으로 유의한 양(+)의 영향을 미치고 있음을 발견하였다. 다섯째, 인건비 비율을 사내근로복지기금과 상호작용하였을 경우 매출액 증가율, 종업원 1인당 매출액 증가율, 종업원 1인당 부가가치생산성 증가율에 각각 체계적으로 유의한 양(+)의 영향을 미치고 있음을 발견하였다. 본 연구는 기금제도가 근로자의 근로의욕을 증진시켜 이직률을 낮추고 장기근속 유도로 숙련된 노동력이 불량률 감소, 원가절감 등으로 생산성을 높인다는 점을 시사한다. 즉 성장성, 노동생산성 등 재무성과가 향상되어 출연하는 기금액이 증가하는 선순환 구조를 이루므로 사내근로복지기금제도를 유용하게 활용할 필요성이 있다. This study analyzed the effects of the company labor welfare fund on financial performance, including growth and labor productivity, by dividing the total number of company work welfare funds into 87 companies that formed company work welfare funds and 72 companies that did not form company work welfare funds for 17 years from 2002 to 2018. The results of the empirical analysis are as follows. First, it was found that the comapnies that formed the company work welfare fund had a significant amount (+) effect on the growth rate of value added productivity per employee, which is labor productivity, in fixed effect. Second, it was found that the gross amount of the basic assets of the company work welfare fund and the year-on-year GDP growth rate used as a substitute for economic growth have systematically significant effects on sales growth, sales growth per employee and value added productivity growth per employee, respectively. Third, it was found that interaction of the labor cost ratio with the company work welfare fund affects systematically significant amounts (+) of increase in sales, increase in sales per employee, and increase in value added productivity per employee, respectively

아동권리협약 채택 20주년의 의미와 과제

김승훈(Seung-Hoon Kim) 大韓赤十字社 人道法硏究所 2009 人道法論叢 Vol.- No.29

아동은 앞으로 미래를 이끌어갈 중요한 자원이며 자산이다. 아동은 잘 성장하고 자신의 잠재력을 최대한 발달시키면서 성장할 권리를 가지며, 사회나 성인들은 이를 지원할 의무를 가지는 것이다. 따라서 이들에게도 독립적인 인간으로서 성인과 동등한 권리가 있다는 것이 유엔 아동권리협약의 지향점이다. 아동의 권리보장 문제는 아직 우리 사회에서 그리 익숙한 개념은 아니지만 국제적으로는 아동권리에 대한 관심이 매우 높은 것이 현실이다. 특히 아프리카 일부 국가에서의 아동이 처한 모습을 보면, 그 나라의 사회문화적인 수준을 알 수 있을 정도이다. 현대사회에서는 수동적인 아동보호에서 능동적인 아동권리 보장이라는 적극적인 아동권리사상이 발달하였지만 아동이 보호의 대상에서 권리의 주체로 인식되기까지 높은 벽을 지나야 했으며 앞으로도 무한한 인내가 필요할 것이다. 아동의 인권을 침해하는 것은 헌법에서 보장하는 국민의 기본권을 위반하는 것이다. 동시에 정부가 아동의 인권 보호를 소홀히 하는 것은 명백히 국제법의 위반이기도 하다. 아동권리협약’ 제19조 제1항은 “당사국은 아동이 부모, 후견인, 기타 아동 양육자의 양육을 받고 있는 동안 모든 형태의 신체적 · 정신적 폭력, 상해나 학대, 방임 또는 유기, 성적 학대를 포함한 혹사나 착취로부터 아동을 보호하기 위하여 모든 적절한 입법적 · 행정적 · 사회적 및 교육적 조치를 취하여야 한다”라고 규정하였다. 따라서 정부는 아동권리협약이 채택된 20주년을 기념하고 그 숭고한 이념을 보급하기 위하여 협약에서 규정한 권리 내용을 전 국민들에게 보급할 수 있는 방안의 마련과, 기존 국내법이 아동권리협약의 내용과 배치될 경우에는 개정을 위하여 노력하여야 할 것이다. 아동의 권리를 지키고 실현시키는 일은 정부, 비정부, 국제기구, 가정, 학교를 망라한 우리 모두의 책임이기 때문이다. Children are important resources and assets to lead the future. Responsibility for the rights of children will ultimately hinge on the translation of agreed principles into national laws, plans of action, and allocation of resources. Children have a privilege to develop their potential capacities while growing up, so that the society or adults will have the obligation to support them. Therefore they are also independent humans what shall enjoy same privileges as adults. This is the convention on the Rights of the Child. The problem with the rights of the child is the society not being familiar with the concept in which it only draw interests in the international scene. In particular, if you see a child in a critical condition in any country in Africa, it could be associated with culture. In modem society, protecting children from passive to active rights of children that rights of child idea is developed positively. However, it must pass through high walls and it will need infinite perseverance before the target of protection of child recognizes to the subject of rights. Infringing the constitutional rights of child is to guarantee people's basic rights are violated. At the same time, the governments neglect of the child's human rights protection is clearly a violation of international law. The Convention on the Rights of the Child, article 19 para. 1, clearly states that, "States Parties shall take all appropriate legislative, administrative, social and educational measures to protect the child from all forms of physical or mental violence, injury or abuse, neglect or negligent treatment, maltreatment or exploitation, including sexual abuse, while in the care of parents, legal guardians or any other person who has the care of the child." Therefore, the government should stipulate right information and action plan to all people, and exert more efforts if the existing laws placed with contents of convention on the rights of child for revision, as well as celebrating 20th anniversary the convention on the rights of child for which was adopted by governments to bring about noble ideas. To protect and work to realize the rights of a child is not only our responsibilitybutalsothegovemments, non-government and international organizations, home and school.

가습기 살균제 연구의 교훈과 의생명과학연구에서의 적용 가능성 ― 연구 관련 이해상충의 해결을 중심으로 ―

김승훈 ( Kim Seung Hoon ) 연세대학교 법학연구원 의료·과학기술과 법센터 2018 연세 의료·과학기술과 법 Vol.9 No.1

It has been over a decade since Hwang Woo-suk's stem cell research, which showed the problem of conflict of interest(COI) in scientific research. However, there is still no system for management of COI. This study starts from recognizing the possibility that the study of humidifier disinfectants can be distorted by COI. The purpose of this study is to review the COI related to the study of humidifier disinfectants and to examine whether the lessons learned here can be applied to biomedical research. The problem of COI in the study of humidifier disinfectants was found to occur in all the research stages (study design, performance, analysis of results, and presentation of results) except the hypothesis setting in the five stages of the study. In order to solve these problems, we analyze the laws and institutions of the United States, which have been aware of COI related to researches from the earliest awareness and have managed policy conflicts. In the United States, an independent organization called the ‘Conflict of Interest Committee’ and ‘Conflict of Interest Officers’ were established to make concrete plans for management of COI in the design phase of the study and to manage them accordingly. Procedures for managing COI include supervision to resolve issues that may arise from COI at the pre-research stage, such as design, performance and reporting of research, and ways to sanction violations of regulations regarding conflicts of interest . In the case of South Korea, where there is little conflict of interest in scientific research, the US policy is worthy of reference. In addition, this study examines how COI are managed in South Korea's biomedical research centered on the role of the Institutional Review Board(IRB), which is a characteristic institution of biomedical research and the Bioethics and Safety Act. In legal issues, the lack of objective criteria and definition of COI has been recognized as a problem, and the IRB has been partially responsible for managing conflicts of interest, but has not exercised its influence throughout the all stages of the study. Therefore, this study suggests a method to maintain the protection of the subjects and enhance the reliability of the biomedical research through the regulation of the definition of COI and the strengthening IRB’s role.