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해양 홍조류 에탄올 추출물의 RAW 264.7 세포와 HEKn 세포에서 항염증 효과
김세율 ( Se Yul Kim ),이숙영 ( Sook Young Lee ),김일철 ( Il Chul Kim ) 대한미용학회(구 대한미용과학회) 2020 대한미용학회지 Vol.16 No.4
The current study investigated the anti-inflammatory effects of ethanol extracts from marine red algae, namely Gracilaria verrucosa, Gracilaria vermiculophylla, Chondracanthus tenellus, and Gloiopeltis furcata in RAW 264.7 cells and HEKn cells. RT-PCR and Western blot analysis were used to confirm the mRNA expression and protein expression patterns of the major factors. Both the cells did not show cytotoxicity to the four red algae extracts. In the LPS-induced inflammatory cell model, iNOS production decreased with increasing concentration of the extracts. At 100 μg/mL concentrations of the extracts, G. verrucose showed the highest inhibitory activity (63.6%). COX-2 also showed an inhibitory effect of 85% or more in the four extracts. TNF-a and lL-1B showed the strongest inhibitory activities in the G. vermiculophylla (73.9%) and G. furcate (94.7%) extracts. In HEKn cells, the COX-2 production decreased significantly with increasing concentration. At 100 μg/mL extract concentration of iNOS and MMP-2, the most potent inhibitory effect was shown by the G. furcate (73.9%), and in both TNF-α and IL-1β, the G. verrucosa extract showed the strongest inhibitory effects at 47.8% and 41.7%, respectively. The ethanol extracts of the four domestic marine red algae are not cytotoxic, and contain effective substances with high anti-inflammatory properties, making them a functional natural material for cosmetics and pharmaceuticals. The value of their use is expected to be very high.
화장품 소재로서의 꽃 10 종 에탄올추출물 생리활성 특성연구
이태범(Tae Bum Lee),소양강(Yang Kang So),김세율(Se Yul Kim),황지영(Ji Young Hwang) 한국약용작물학회 2020 한국약용작물학회지 Vol.28 No.4
Background: We investigated the antioxidant, anti-wrinkles, whitening, and moisturizing properties and amounts of phenolic compounds of ethanol extracts from flowers of 10 resource plants from Namwon and Mt. Jiri., Korea. Methods and Results: We measured antioxidant efficacy based on the total polyphenol, and total flavonoid content, and the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. We evaluated the inhibitory effect on melanin synthesis and tyrosinase activity for the whitening effect. Furthermore, we analyzed the elastase and matrix metalloproteinase-1 (MMP-1) inhibition activity for anti-wrinkle capacity. To evaluate the moisturizing effect, we examined hyaluronan synthase (HAS) mRNA expression. In addition, the 19 phenolic compounds were detected using high performace liquid chromatography (HPLC). Among the 10 flowers, the antioxidant effect was high in the order of Rosa multiflora, Nelumbo nucifera, and Elsholtzia splendens. Whitening effect was high in the order of N. nucifera, R. multiflora, and Dendranthema zawadskii. As for the anti-wrinkle property, N. nucifera was the most effective followed by R. multiflora. Taraxacum coreanum was the best for moisturizing effect, followed by D. zawadskii, and E. splendens. Seven phenolic compounds were detected in the extracts of the 10 flowers. Conclusions: Overall, the extracts of five flowers extracts showed strong potential as antioxidant, whitening, anti-wrinkle, and moisturizing functional cosmetic agents.