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김성록 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4
There have been numerous trials of screening test for early diagnosis without much satisfactory yield in all kinds of cancers. However, some screening tools including tumor markers were found to be useful and recommended to apply in certain sorts of cancers. The author reviewed in this article recently updated screening tests abroad as well as in Korea, where consensus meetings for the screening were held lately for the early diagnosis in several cancers. In conclusion, more prudent use of the screening tests on the basis of updated knowledge is required for the early diagnosis of cancers.
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김성록,윤종보,조용호 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.2
In patients with end-stage renal disease, depressed taste acuity may often affect their food intake and causes malnutrition. We measured mean recognition thresholds for the four primary tastes before and after hemodialysis to evaluate the efficacy of hemodialysis on taste acuity and measured serum zinc concentrations to determine the relationship between taste acuity and zinc status in 21 patients undergoing hemodialysis. The results were as follows : 1) Mean taste recognition thresholds of sour(0.0034±0.0021 N), sweet(0.027±0.012 M), and salty(0.027±0.014 M) were significantly higher than those of controls(0.0012±0.0007 N, 0.016±0.008 M, and 0.015±0.008 M, respectively)(P$lt;0.05). 2)After hemodialysis, mean taste recognition thresholds of sour(0.0014±0.0011 N), sweet(0.015±0.011 M), and salty(0.020±0.011 M) were significantly decreased(P$lt;0.05) but were not different from those of controls. 3) The mean recognition threshold for bitter was not improved after hemodialysis and was not different fromcontrols. 4) The serum zinc concentration of patients with chronic renal failure was not different from that of controls. Finally, the mean taste recognition thresholds for sour, sweet, and salty were decreased in patients with end-stage renal disease and were improved after hemodialysis. The mean taste recognition threshold for bitter was not improved after hemodialysis and was not different from that of controls.
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복부 초음파검사 및 간주사를 통한 위암 환자의 기 및 수술 여부 결정
김성록,정해철,문기석,최원락,김병제,박주열 인제대학교 1986 仁濟醫學 Vol.7 No.2
저자들은 1981년 1월부터 1985년 6월까지 인제의과대학 부산백병원에 입원하여 위내시경검사 및 직시하 생검에서 위선암으로 확인된 총 130예를 대상으로 근치적 절제술의 효과를 높이기 위하여 수술 전에 간주사법 및 복부초음파 검사를 시행한 61예와 둘 다 시행하지 않았던 69예를 대상으로 개복수술 시행 후 아래와 같은 성적을 얻었기에 문헌 고찰과 함께 이를 보고한다. The reliablity of physical examination, liver scan and abdominal ultrasonography in detecting Cancer metastasis has been evaluated 130 patients with histologically proven stomalch Cancer(61 cases was performed Liver scan and abdominal ultrasonography.) who had admitted to InJe Medical College, Pusan Paik Hospital from January 1981 to June 1985. Confirmation on Laparotomy showed the following results. 1) Ninety nine cases out of one hundred and thirty were over the age of 41 years (76.2%). 2) Liver scan and abdominal ultrasonography were 93.4% accurate and 90.2% accurate, respectively, in detecting liver metastasls. 3) Abdominal ultrasonography were 39.3% accurate in detecting lymph node Metastasis. 4) Abdominal ultrasonography were 65.6% accurate in detecting other organs' metastasis. 5) In a composite analysis on hepatic metastasis, the diagnostic accuracy was not improved by combining abdominal ultrasonography and liver scan examination. 6) The additional benefit of abdominal ultrasonography when liver scan was in error was an increase in accuracy of 9.8% for liver scan alone. 7) Borrmann's type IV had the highest incidence of TMN classification stage IV(75.7%). Those who had palpable epigastric mass show higher incidence of TMN classification stage IV compaired with these who had not. 8) Comparison of TMN classification between normal and not taken group of Liver scan and ultrasonograpny showed the highest incidence of TMN classification stage IV in broth groups.
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위장관계 종양의 Estrogen 수용체 및 병리임상학 연구 : 위암을 중심으로 in Stomach Cancer Cases
김성록,조혜제,김홍용 인제대학교 1992 仁濟醫學 Vol.13 No.2
저자는 위장관계 암, 특히 위암에서의 호르몬의 역할과 호르몬요법의 가능성을 추구하기 위하여 21명의 위절제수술을 받은 환자의 위암조직에서 면역조직화학검사를 통하여 에스트로젠 수용체를 검색하여 그 임상병리적 양상과 함께 보고하는 바이다. The estrogen receptors were examined by immunohistochemical analysis(IHA) on 21 cases of resected stomach cancel. The results Were: 1.Seven out of 21 cases showed positive reaction ; Grade (G) 3 staining in 1 case, G2 in 3 and G1 in 3 cases. 2.Among positives, 1 G2 had poorly differentiated tumor (PD), 2 G2 had moderatly differentiated (MD) and 1 G2 had PD, and 3 G2 had all MD. 3.Among all 21 cases, there were 2 well differentiated tumors that were ER negative ; 5 were positive among 11 MD cases ; 2 were positive among 8 PD cases. 4.Five out of the 6 evaluable ER positives and 11 out of the 13 evaluable negatives showed NED (no evidence of disease) or responses to chemotherapy. 5.Two out of 7 patients at or older than 60 year old and 1 out of 3 patients below 40 year old were ER positve. 6.IHA was good to discern ER positive area in tumor tissue, but needed more objective parameter to assess the degree of ER positivity. 7.Concommitant assay of the other sex hormone receptors like progesterone or androgen receptor as well as further trial of ER assay, and trial with, tamoxifen and / or progesterone seemed to be necessary as further investigations for more accurate assessment of the roles of the sex hormones in the pathogenesis and the basis of the treatment of stomach cancer.
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김성록,김두순 한국국토정보공사 2018 지적과 국토정보 Vol.48 No.2
It is very important to understand the factors affecting the occurrence of vacant houses in research on them. The purpose of this study is to analyze the factors affecting the rural vacancy occurrence. This study set 121 research areas and selected eight independent variables (Aged house rate, housing transaction rate, house diffusion ratio, local extinction index, net migration rate, regional aging index, the ratio of the number of employees to population and financial independence rate) and one dependent variable (vacant house rate). As a result of the study, first, both Model 1 for the entire general agricultural fishing village area and Model 2 for the county (gun) area were statistically significant, there was no problem with the independence of residual. Second, local extinction index and aged house rate had a statistically significant positive (+) relationship in both Model 1 and Model 2. Third, diffusion ratio of house had a statistically significant positive (+) relationship only in Model 1, and housing transactions rate had a statistically significant negative (-) relationship in Model 2. The implications of the study were drawn as follows: First, the increase in the house diffusion ratio without growth in households and population suggests the increase of the probability of the vacancy occurrence in the area, and the higher the aged house rate, the higher the probability of the vacancy occurrence. Second, for the revitalization of housing transactions, it is necessary to have an investment inflow in the area for mid- to long-term development. Third, local extinction index has a significant relationship with vacant house rate, it is necessary to introduce a local revitalization policy from a long-term perspective for the permanence of the area. 빈집 연구에 있어 발생 영향 요인 파악은 매우 중요하다. 연구의 목적은 농촌 지역의 빈집 발생에 영향을 주는 요인을 분석하는 것이다. 121개 연구 대상 지역을 설정하고, 8개의 독립변수(노후 주택 비율, 주택 거래 비율, 주택 보급률, 지역 소멸 지수, 순 이동률, 지역 노령화 지수, 인구 대비 종사자 수, 재정자립도)와 1개 종속변수(빈집 비율)를 선정하였다. 연구 결과, 첫째, 일반농산어촌 지역 전체를 대상으로 하는 모형 1과 군 지역을 대상으로 하는 모형 2는 모두 통계적으로 유의미하였으며, 잔차의 독립성에 문제가 없었다. 둘째, 지역 소멸 지수 및 노후 주택 비율의 경우 모형 1과 모형 2에서 모두 통계적으로 유의미한 정(+)의 관계가 있는 것으로 분석되었으며, 셋째, 주택 보급률의 경우, 모형 1에서만 통계적으로 유의미한 정(+)의 관계가 있는 것으로 분석되었고, 주택 거래 비율의 경우, 모형 2에서 통계적으로 유의미한 반(-)의 관계가 있는 것으로 분석되었다. 연구의 시사점가 도출되었다. 첫째, 가구 및 인구 증가가 없는 주택 보급률의 상승은 지역 내 빈집의 발생 확률을 높이는 것을 시사하고, 노후 주택 비율이 높을수록 빈집 발생 확률이 높아진다. 둘째, 주택 거래 활성화를 위해서는 지역의 중장기 발전을 위한 투자 유입이 필요하다. 셋째, 지역 소멸 지수는 빈집 비율과 유의미한 관계를 가지므로, 지역의 영속성을 위해 장기적인 시각에서 지역 활성화 정책이 도입되어야 한다.
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진행성 위장관 암에 대한 5-Fluorouracil, Leucovorin 및 Mitomycin-C 복합 화학요법
김성록 인제대학교 1990 仁濟醫學 Vol.11 No.4
진행성 위장관의 악성종양에 대한 약물 치료는 아직도 만족스럽지 못하며, 유효한 경우에도 약물 치료에 따른 독성 등으로 계속 치료하기가 곤란한 경우가 많았다. 이에 저자는 아직도 위장관암의 주된 치료제인 5-Fluorouracil과 Mitomycin-C에 5-FU의 효력 증강제인 Leucovorin을 첨가하여 제2위상 시험을 한 후 그 효과와 독성을 관찰하였다. A phase II study was conducted to determine the efficacy and toxicity of 5-fluorouracil (5-FU), low dose leucovorin (LV) and mitomycin-C (MMC) in patients (pts) with advanced gastrointestinal tract cancer. The treatment regimen consisted of 5-FU 375 mg/m2 IV over 15 minutes daily for 5 days, just after IV bolus of LV 20 mg/m2 each, and MMC IV bolus 9 mg/m2 which was reduced to 7 mg/m2 from the second cycle. The treatment was repeated every 3-4 weeks, 21 eligible pts have been entered on study. 18 pts are presently evaluable for response and toxicity ; 3 pts were lost to follow up after chemotherapy. Among 18 evaluable pts, there were 111 pts with stomach cancer, pancreas 2, bile duct 1, gall bladder 1, and colon 3. 17 patients had adenocarcinoma ; 1 bile duct cancer was not confirmed pathologically. The median alee was 57 (Range 37-84) years. 3 pts had 5-FU containing chemotherapy previously. The pts on this trial received a median of 2 cycles (range 1-7). 1pt (bile duct) had radiotherapy of 800 cGy after chemotherapy. There were partial reponses (stomach 7, pancreas 1) tasting 1-7+months and 3 objective responses (for "evaluable disease". stomach 2, bile duct 1) lasting 1-4+months. 2 pts with stable disease or progressive disease on prior 5-FU containing chemotherapy had partial responses. 5 pts were in stable disease and 2 in progressive desease. 2 pts died so far ; one in one month with progressive disease and the other in 6 months after treatment, with the remission duration of 4 months. Toxicities were tolerable ; no one was hospitalized due to toxicity. Grade (G) 1 nausea / emesis was observed in 4 pts and G 2 in 1 pt. G 2 mucositis in 3 pts, diarrhea G 1 in 2 pts and G 2 in 1 pt were noted. Granulocytopenia G 1 in 4 pts, G 3 in 2 pts and G 4 in 1 pt (who had radiotherapy), and G 1 thrombocytopenia in 2 pts were observed. This appears to be a well tolerated regimen having comparable effects. The study continues to accrue pts to better define the response rates and effects on survival.
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