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천련자 추출물이 간기능(肝機能)에 미치는 영향(影響)(I) -천련자의 분획이 약물대사효소계 및 담즙분비에 미치는 영향-
김부생,최종원,이정규,Kim, Bu-Saeng,Choi, Jong-Won,Lee, Chung-Kyu 한국생약학회 1993 생약학회지 Vol.24 No.1
Meliae toosendan Fructus is the fruit of Melia toosendan $S_{IEB}$. et $Z_{UCC}$. (Meliaceae), which is written in oriental terminology as clearing heat and drying dampness, and also explained using liver, stomach and small intestine for channels entered. Among the five fractions prepared from methanol whole extractive of the herb, the chloroform fraction which suggests the presence of triterpenoid, flavonoid and alkaloid stimulated the activities of drug metabolizing enzymes and bile secretion and lowered the serum transaminase activities of liver damaged by carbon tetrachloride.
김부생,김혜경,최종원,이정규,Kim, Bu-Saeng,Kim, Hye-Kyung,Choi, Jong-Won,Lee, Chung-Kyu 한국생약학회 1996 생약학회지 Vol.27 No.1
A triterpenoid(melianone) and a limonoid(28-deacetyl sendanin) were isolated from the chloroform fraction of Meliae toosendan Fructus, the rippen fruits of Melia toosendan SIEB. et ZUCC.(Meliaceae) and were applied to serial experiments to clarify the liver protective activities. We found that the compounds promoted slightly the drug metabolizing enzyme activities and decreased serum transaminase activities which was elevated by carbon tetrachloride intoxication. And also they slightly increased the secretion of bile juice in rat.
천련자 추출물이 간기능(肝機能)에 미치는 영향 (II) -천련자 종자유(種子油)가 흰쥐의 지질대사(脂質代謝)에 미치는 영향-
류만영,김부생,최종원,이정규,Ryu, Man-Young,Kim, Bu-Saeng,Choi, Jong-Won,Lee, Chung-Kyu 한국생약학회 1994 생약학회지 Vol.25 No.3
Meliae toosendan Fructus, the seed of Pagoda tree, Melia toosendan Sieb. et Zucc. (Meliaceae), has been used as a liver protective herbal drug in the Orient. Administration of seed oil to hyperlipedemic rats revealed the lipid lowering effects in serum and liver tissue without any toxicity in body weight increase and liver function.