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김정우,김병각,최응칠,심미자,김하원,김경제,이승희 한국균학회 1985 韓國菌學會誌 Vol.13 No.4
Of 450 strains isolated from the soil microbes collected in various locations in Korea, a strain had a strong inhibitory activity against bacterial α-amylase and was named strain DMC-72 of the genus Streptomyces. The amylase inhibitory metabolite produced by this strain was purified by means of acetone precipitation, adsorption on Amberlite IRC-50 and SP-Sephadex C-25. The inhibitor was found to be a derivative of oligosaccharides by spectral and chemical data. The inhibitor was stable at the pH range of 1∼13 and at 100℃ for half an hour, also inhibited other amylases such as salivary α-amylase, pancreatic α-amylase, fungal α-amylase and glucoamylase. However, it showed no inhibitory activity against α-glucosidase, β-glucosidase, dextranase, and β-amylase. The kinetic studies of the inhibitor showed that its inhibitory effects on starch hydrolysis by α-amylase were noncompetitive.
알파-아밀라제 저해제 생산 방선균 Streptomyces minoensis DMCJ-144 의 균주개량
강동희,이재우,김병각,최응칠,김숙경 한국응용약물학회 1993 Biomolecules & Therapeutics(구 응용약물학회지) Vol.1 No.1
Strain of Streptomyces minoensis DMCJ-144 was tried to be improved so that it produces much more the α-amylase inhibitor. Streptomyces minoensis DMCJ-144 was treated with 1 ㎎/㎖ (pH 9.0) of N-methyl-N'-nitro-N-nitrosoguanidine at 30℃ for 60 min and irradiated with UV light distanced 30 cm for 20 min. After mutagenesis, surviving colonies were cultured on the CM contaning acriflavine (10㎍/㎖) three times in order to enhance the mutability. And then through multi-level screening, colonies that α-amylase inhibitor productibility was improved were selected by modified-blue value method. After third acriflavine treatment, α-amylase inhibitory activities of selected colonies were found to be much better as compared with that of parent strain. One mutant strain showed 5.4 time inhibitory activity than the parent strain.