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- 저자 : 김민범(Min-Bum Kim) (검색결과 11 건)
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이강욱(Gang Wook Yi),이정호(Chung Ho Lee),김민범(Min Bum Kim),박헌진(Hyun Jin Park),김삼용(Sam Yong Kim),신영태(Young Tai Shin),노흥규(Heung Kyu Ro),이복희(Bok Hee Lee) 대한내과학회 1989 대한내과학회지 Vol.37 No.6
N/A To investigate cell mediated immunity in chronic renal failure, delayed cutaneous hypersensitivity responses to 7 microbial antigens and peripheral blood T cell subsets using monoclonal antibodies against T helper-inducer, T cytotoxic-suppressor and total T cell subsets were measured in 23 uremic patients and 17 healthy controls. IgG production by peripheral blood lymphocytes in response to PWM triggering was evaluated. The results were summarized as follows: 1) Total peripheral blood lymphocyte counts were significantly decreased in patients with chronic renal failure. 2) T cell subsets in uremic patients were not different from those in healthy controls. 3) Delayed cutaneous hypersensitivity was significantly depressed in uremic patients, 4) IgG production by peripheral blood lymphocyte culture in response to PWM triggering was significantly decreased in patients with chronic renal failure. In conclusion, decreased peripheral blood lymphocyte counts and impairment of T cell function other than T cell subsets are thought to be involved in depressed cell mediated immunity in chronic renal failure.
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김민범,이정호,신영태,김삼용,노흥규 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.1
To investigate the thyroid hormonal changes and their mechanisms in patients with chronic renal failure (CRF), the author measured serum levels of the thyroid hormones using radioimmu-noassay and calculated each ratio of serum thyroid hormones in 17 patients with CRF. Ten patients were on hemodialysis therapy and seven patients had not undergone hemodialysis. The following results were obtained. 1) The serum T3 and T4 concentrations were significantly lower in patients with CRF(0.7±0.47㎍/1 and 5.53±2.95㎍/dl, respectively) than in normal subjects(1.21±0.18㎍/1 and 9.46±1.92㎍/dl, respectively. 2) The serum FT4(free T4) concentration was significantly lower in patients with CRF(1.20±0.50μu/dl) than in normal subjects(1.01±0.48μu/dl). 4) The serum rT3(reverse T3) concentration in patients with CRF(285.7±148.1pg/ml) tends to be greater than normal subjects(204.6±43.3pg/ml). But is was not significant statistically. 5) The calculated serum concentration ratio of T3/T4 in patients with CRF(0.17±0.04: presented as Mean±SEM) did not differ significantly from that of normal subjects(0.13±0.01). But the serum concentration ratio of rT3/T4 in patients with CRF(78.78±18.98) was significantly greater than in normal subjects(21.90±1.04). 6) There was no significant difference in thyroid functions between male and female patients with CRF, and also between patients on hemodialysis and non-dialyzed uremic patients. It was concluded that the serum T3, T4, FT4 concentration were significantly decreased in patients with CRF, while the serum TSH concentration was significantly increased. The calculated serum concentration ratio of rT3/T4 was also significantly increased in patients with CRF. Thus is appears that abnormalities found in patients with CRF may reflect both the possible intrathyroidal abnormalities and alteration of serum rT3 metabolism with increased peripheral generation of rT3 from T4.
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신영태,김민범,이정호,김상용 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2
To elucidate the hematologic alterations in Korean hemorrhagic fever(KHF), hemoglobin concentration, reticulocyte percent, platetet count, fibrinogen concentration, fibrin degradation product(FDP), prothrombin time(PT) and partial thromboplastin time(PTT) were measured in 27 patients with KHF who were admitted to Chungnam National University Hospital from Oct. 1986 to Sept. 1988. The results were as follows 1. 19 patients(70.4%) out of 27 patients with KHF revealed petechial hemorrhage on axilla and soft palate. UGI bleeding, epistaxis and gross hematuria were also observed in 2, 2 and 2 patients, respectively. 2. In early phase of KHF, hemoglobin concentration showed normal in 21 patients (77.8%), reduced in 5 patients (18.5%)'and elevated in 1 patient. In late phase of KHF, it showed normal in 16 patients(59.3%) and reduced in 11 patients (40.7%). 3. Reticulocyte percent was significantly lower in early phase than late phase of KHF. 4, In early phase of KHF, peripheral blood leukocyte count was elevated in 23 patients(81.2%). In late phase, it became to normal in most patients. 5. In early phase of KHF, peripheral blood platelet counts was decreased in 24 patients (88.9%). In late phase, it became to normal in most patients. 6. In early phase of KHF, fibrinogen concentration was decreased in 3 (13.6%) out of 22 patients. In late phase it became to normal in all patients. FDP showed increased in 9 (40.9%) out of 23 patients in early phase of KHF and 2 (18.2%) out of 11 patients in late phase of KHF 7. PT showed normal range in all patients of early and late chase of KHF. In early phase, PTT was prolonged in 7 (29.2%) out of 24 patients and it became to normal in late phase of KHF.
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충청지방에서 발생한 한국형 출혈열 104예의 임상적 고찰
이정호,신승훈,김민범,신영태 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.1
A clinical study was carried out on 104 cases of Korean Hemorrhagic Fever who were admitted to Chungnam National University Hospital from Januray 1982 to December 1988. 104 cases among the patients were confirmed -by serologic test. The resutls were as follows: 1. The peak monthly incidence was November. The peak age incidence were 5th and 6th decade and male to female ratio was 2.5:1. The occupation of the patients were variable, but farmer was the most prevalent. 2. Most patients entered hospital in oliguric stage and the mean duration from onset of symptoms to admission was 5 days. 11 OUT OF 104 patients were non-oliguric stages. 3. The reguent and pertinent symptoms and signs were fever, chills, general myalgia, abdomical patin, back pain, abdominal and costovertebral angle tendernes sand bleeding tendencies. 4. The important laboratory findings for diagnosis were leukocytosis, thrombocytoenia, elevated blood urea nitorgen and creatinin. 5. Hypertension was noticed transiently in 42 cases(40.4%). Other complications were infection, melena, pleural effusion, convulsion and premature repture of membrane in pregnancy in 4, 3, 3, 2 and 1 cases respectively. 6. 26 patients who showed severe acute renal failure were treated with acute hemodialysis while 78 patients with conservative treatment. All patients except one who developed unidentified cerebral dysfunction were discharged with improvement.
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急性骨髓性 白血症에서의 試驗管內 集落細胞 形成에 관한 연구
고석만,조덕연,박철신,강원권,김민범,김삼용,노흥규 忠南大學校 癌共同硏究所 1991 癌共同硏究所 硏究誌 Vol.1 No.1
To evaluate the in vitro granulocyte-macrophage colony formation in acute myeloblastic leukemia and the prognostic implications of these results, the author performed the in vitro agar culture of bone marrow cells in 10 patients with acute myeloblastic leukemia (AML) and 5 control subjects. Culture medium was composed of 20% fetal calf serum(FCS), 50% Iscove's medium, 0.3% agar, 10% colony stimulation factor (CSF), and 2×105 cells/ml. Human placental conditioned medium (HPCM) and phytohemagglutinin-leukocyte conditioned medium (PHA-LCM) were used as colony stimulating factor. Colony counting was done on 7th day of culture. Colony was defined as containg 20 or more cells, and cluster was defined as containing 3 - 19 cells. The results were as followings, 1. In control subjects, the number of clusters formed was 3-47/2×10^(5) cells (20±19)and that of colonies was 5-24/2×10^(5) cells (14±9) when stimulated with HPCM. When stimulated with PHA-LCM, the number of clusters formed 5-39/2×10^(5) cells(18±16) and that of colonies was 6-13/2×10^(5) cells (9±3). 2. In AML patients, 3 groups were recognized according to pattern of colony formation : 1) non-forming 2) cluster forming 3) both cluster and colony forming. Of 10 cases, 5 cases were 'non-forming', 2 cases were 'cluster forming'; and 3cases wer cluster and 'colony forming'; 3. All 5 cases 'non-forming' cases, one of 2 cases of 'cluster forming'; and none of 3 cases of 'cluster and colony forming' achieved complete remission. So, there was significant difference in remission rate in the different growth types. These results suggest that granulopoiesis in AML patients is impaired and the pattern of in vitro CFU-L(colony forming unit-leukemia) formation has prognostic significance.
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急性骨髓性 白血病에서의 試驗管內 集落細胞 形成에 관한 연구
고석만,조덕연,박철신,강원권,김민범,김삼용,노흥규 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2
To evaluate the in vitro granulocyte-macrophage colony formation in acute myfloblastic leukemia and the prognostic implications of these results, the author performed the in vitro agar culture of bone marrow cells in 10 patients with acute myeloblastic leukemia (AML) and 5 control subjects. Culture medium was composed of 20% fetal calf serum(FCS), 50% Iscove's medium, 0.3% agar, 10% colony stimulation factor (CSF), and 2 × 10 exp (5) cells/ml. Human placental conditioned medium (HPCM) and phytohemagglutinin-leukocyte conditioned medium (PHA-LCM) were used as colony stimulating factor. Colony counting was done on 7th day of culture. Colony was defi ned as containg 20 or more cells, and cluster was defined as containing 3-19 cells. The results were as followings, 1. In control subjects, the number of clusters formed was 3-47/2 × 10 exp (5) cells (20±19)and that of colonies was 5-24/2 × 10 exp (5) cells (14±9) when stimulated with HPCM. When stimulated with PHA-LCM, the number of clusters formed 5-39/2 × 10 exp (5) cells(18±16) and that of colonies was 6-13/2 × 10 exp (5) cells (9±3). 2. In AML patients, 3 groups were recognized according to pattern of colony formation: 1) non-forming 2) cluster forming 3) both cluster and colony forming. Of 10 cases, 5 cases Were `non-forming', 2 cases were `cluster forming'; and 3cases wer cluster and `colony forming'; 3. All 5 cases 'non-forming' cases, one of 2 cases of `cluster forming'; and none of 3 cases of `cluster and colony forming' achieved complete remission. So, there was significa nt difference in remission rate in the different growth types. These results suggest that granulopoiesis in AML patients is impaired and the pattern of in vitro CFU-L(colony forming unit-leukemia) formation has prognostic significance.
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