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6-Amino-2-N-(n-propionylamino)selenazolo[4,5-f]indan의 합성
김민겸,마은숙,Kim, Min-Kyeom,Ma, Eun-Sook 대한약학회 2008 약학회지 Vol.52 No.1
2-Aminothiazole ring as a bioisoster of catechol in dopamine has provided with good oral availability and lipophilic property. Selenium was reported to have an improved antioxidant ability and to reduce the loss of dopamine. 2-Aminoindan, is a rigid form of dopamine, was evaluated as a dopamine agonist with low neurotoxocity. In order to develop a novel dopamine agonist, we tried to synthesize the selenazoloaminoindan derivative that is a hybrid structure of aminoindan and aminoselenazole instead of aminothiazole. 2-Indanone-2-oxime was reduced with $TiCl_4$ and $NaBH_4$ to form 2-aminoindan, which was reacted with propionyl chloride to give 2-N-n-propionylaminoindan (2). Compound 2 was reduced with $TiCl_4$ and $NaBH_4$ to afford 2-N-n-propylaminoindan (3) and it was nitrated and reduced to form 5-amino-2-N-n-propylaminoindan (5), which was reacted with KSeCN, $Br_2$, and glacial acetic acid to give 4,6-dibromo-5- amino-2-N-n-propylaminoindan (7) instead of selenazole ring formation. Otherwise, compound 2 was nitrated and hydrogenated to form 5-amino-2-N-n-propionylaminoindan (9), which was treated with KSeCN, $Br_2$, and glacial acetic acid to give 4,6-dibromo-5-amino-2-N-n-propionylaminoindan (10). Compound 9 was cyc1ized with KSeCN and glacial acetic acid in the absence of $Br_2$ to give 6-amino-2-N-(n-propionylamino)selenazolo[4,5-f]indan (11).
김민겸 ( Min-kyeom Kim ),김승현 ( Seunghyun Kim ),윤재원 ( Jae-won Yun ),정효균 ( Jeong-hyo Gyun ),곽민준 ( Min-jun Kwak ),안예린 ( Yea-lin Ahn ),박찬욱 ( Chan-wook Park ),김윤철 ( Youn-chul Kim ),서종환 ( Jonghwan Suhr ) 한국복합재료학회 2021 Composites research Vol.34 No.4
적층제조 기술의 발전으로 복잡한 구조의 제조가 용이해짐에 따라, 기존에 존재하지 않은 특성을 지닌 메타물질에 대한 관심이 커지고 있다. 기존에 존재하지 않은 기계, 음향, 열, 전자기 및 광학 특성을 지닌 메타물질은 높은 공학응용(Engineering applications) 가능성을 보여, 새로운 메타물질 개발 및 설계방안에 대한 연구를 지속적으로 진행하고 있다. 이에 본 논문에서는 메타물질의 여러 특성 중 기존에 존재하지 않은 기계적 특성을 지닌 메타물질의 특성, 거동 및 물성을 소개하고 설계방안을 제시하고자 한다. 또한 설계한 메타물질을 제조하기 위해 여러 적층제조 방식별 메타물질 제조특성 들을 검토하여, 메타물질의 산업에서의 활용 가능성을 제시하고자 한다. As an additive manufacturing achieves technological advances, it enables to manufacture complex structures with saving a cost and time. Therefore, metamaterials, which has geometric complexity, have gradually gathered attention due to the unprecedented properties: the unprecedented mechanical, thermal, electromagnetic, and optical properties. The metamaterials could exhibit a high potential in engineering applications, and thus it has been steadily investigated to design or/and develop novel metamaterials. Here, mechanical metamaterials, which had been reported, were reviewed to suggest the way to design and fabricate the metamaterials for industrial applications.
레이저로 적층 제조한 금속 기지재 복합재료의 설계 및 제조 연구동향
김민겸 ( Min-kyeom Kim ),김태환 ( Taehwan Kim ),김주원 ( Ju-won Kim ),김동원 ( Dongwon Kim ),방영젠 ( Yongjian Fang ),노종환 ( Jonghwan No ),서종환 ( Jonghwan Suhr ) 한국복합재료학회 2021 Composites research Vol.34 No.4
금속 기지재 복합재료들(MMCs, Metal matrix composites)은 우수한 기계적 물성(강성, 강도, 마모 저항성, 경도 등)과 뛰어난 특성(열전도, 전기전도도, 부식 저항 등)으로 다양한 산업군에 활용되고 있다. 적층제조 기술이 발달함에 따라 복잡한 형상을 시간과 비용을 절약하여 제조할 수 있다는 이점으로, 적층 제조한 MMCs에 관한 연구가 활발하게 이루어지고 있다. 하지만 MMCs를 적층 제조할 경우, 다양한 원인들에 의해 여러 문제들이 발생할 수 있다. 따라서 본 연구에서는 다양한 MMCs의 특징들을 소개하고, 위의 문제들이 발생하는 원인을 고찰하여 소재와 Powder bed fusion (PBF) 공정 설계 관점에서 해결책을 제시하고자 한다. 본 논문은 향후 PBF 방식으로 적층 제조한 MMCs를 개발할 때 설계 및 제조 가이드라인을 제시하여 줄 수 있을 것이다. Metal matrix composites (MMCs) were widely used in various industries, due to the excellent properties: high strength, stiffness, wear resistance, hardness, thermal conductivity, electrical conductivity, etc. With additive manufacturing (AM) technology rapidly developed, AM MMCs have been actively investigated thanks to the cost- and time-saving manufacturing. However, several issues still need to be addressed before fabricating AM MMCs. Here, several types of MMCs were introduced and MMCs’ design methods to tackle the issues were suggested in a powder bed fusion (PBF) technique. The paper could come up with a guideline for the material and process design of MMCs in the PBF technique.