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      • KCI등재SCOPUS

        상피성 난소암에 있어서 증식세포핵 항원의 예후인자로서의 의의

        신승화 ( Seung Hwa Shin ),안준모 ( Joon Mo Ahn ),김동휘 ( Dong Hwai Kim ),박은동 ( Un Dong Park ) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.12

        Proliferating cell nuclear antigen(PCNA) is a stable cell cycle related antigen. PCNA is considered to be a marker of cell proliferation. The aim of this study was to evaluate the possible correlation between the expression of PCNA and grade, stage and survival in epithelial ovarian cancers. The expression was investigated by immunohistochemical method(ABC) on 50 cases of epithelial ovarian cancer. The material consisted of serous cystadenocarcinoma 60%(30/50), mucinous cystadenocarcinoma 36%(18/50) and endometroid carcinoma 4%(2/50). The PCNA labelling index(LI) ranged from 7.5% to 92.5% with a median value of 44.9%. In the grade 1 tumor, PCNA LI was 37.5% and in the grade 2 & 3 tumors PCNA LI were 58.6% and 78%, retrospectively(p<0.05). Also, a positive correlation was found between PCNA LI and clinical stages(p<0.05). For patients with PCNA LI greater than the median(high proliferation group), the estimated 3-year survival rate was 44.4% ; for patients with PCNA LI below the median(low proliferative group), the estimated 3-year survival rate was 73.9%(p<0.05). In conclusion, PCNA LIis one of the valuable prognostic factors of epithelial ovarian cancer.

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