Digital Breast Tomosynthesis as a Breast Cancer Screening Tool for Women with Gynecologic Cancer

김다훈,정진,차은숙,이지은,김정현 대한영상의학회 2020 대한영상의학회지 Vol.81 No.4

Purpose The purpose of our study was to evaluate digital breast tomosynthesis as a breast cancer screening modality for women with gynecologic cancer. Materials and Methods This retrospective study included patients with underlying gynecologic malignancies who underwent screening digital breast tomosynthesis for breast cancer. The cancer detection rate, recall rate, sensitivity, specificity, and positive predictive value (PPV) were calculated. PPV1 was defined as the percentage of all positive screening exams that have a tissue diagnosis of cancer within a year. PPV2 was defined as the percentage of all diagnostic exams (and Breast Imaging Reporting and Data System category 4, 5 from screening setting) with a recommendation for tissue diagnosis that have cancer within a year. PPV3 was defined as the percentage of all known biopsies actually performed that resulted in a tissue diagnosis of cancer within the year. For each case of screen-detected cancer, we analyzed the age, type of underlying gynecologic malignancy, breast density, imaging features, final Breast Imaging Reporting and Data System assessment, histologic type, T and N stages, molecular subtype, and Ki-67 index. Results Among 508 patients, 7 with breast cancer were identified after a positive result. The cancer detection rate was 13.8 per 1000 screening exams, and the recall rate was 17.9%. The sensitivity was 100%, and the specificity was 83.2%. The false negative rate was 0 per 1000 exams. The PPV1, PPV2, and PPV3 were 7.7, 31.8, and 31.8, respectively. Conclusion Digital breast tomosynthesis may be a promising breast cancer screening modality for women with gynecologic cancer, based on the high cancer detection rate, high sensitivity, high PPV, and high detection rate of early-stage cancer observed in our study.

T1-Staging for Urinary Bladder Cancer with the Stalk and Inchworm Signs with 3.0 Tesla MRI

김다훈,강병철,정진 대한영상의학회 2020 대한영상의학회지 Vol.81 No.5

Purpose To evaluate the diagnostic utility of the stalk and the inchworm sign on preoperative MRI for detecting superficial bladder cancers, and to compare the diagnostic performance between the stalk and the inchworm sign. Materials and Methods We retrospectively reviewed 240 patients (505 tumors) who had undergone radical cystectomy. The tumors were classified as follows: superficial or invasive tumors indicated by the stalk or inchworm sign on 3.0 Tesla MRI. We evaluated the diagnostic accuracy of the stalk and inchworm signs, by comparing each finding with the postoperative pathologic T stage. We compared diagnostic performance between them statistically. Results The stalk and inchworm signs showed high specificity (93% and 91%, respectively), positive predictive values (89% and 90%, respectively), and acceptable accuracy (70% and 74%, respectively), but low sensitivity (54% and 61%, respectively) and negative predictive values (60% and 63%, respectively). There was no statistically significant difference between the two signs (p > 0.05). Conclusion Superficial bladder cancers could be differentiated from invasive tumors using the stalk or inchworm sign on MRI.

기저질환 및 위험인자가 동반되지 않은 젊은 COVID-19환자에서 발생한 급성신부전 1예

김다훈,유연실,강나리,최재신 대한내과학회 2022 대한내과학회 추계학술발표논문집 Vol.2022 No.2

혼합 정수 선형 계획법을 활용한 단일 버티포트 내 UAM 리소스 최적화

김다훈(DaHoonKim),박준석(JunseokPark),신동혁(YoungjaeShin),신영재(YoungjaeShin),이승운(SeungwoonLee),김정석(JeongseokKim),정설영(SeolyoungJeong) 한국정보기술학회 2024 Proceedings of KIIT Conference Vol.2024 No.5

본 논문은 도심 항공 모빌리티(UAM, Urban Air Mobility) 의 핵심 구성 요소 중 하나인 버티포트(Vertiport)의 효율적인 운영을 지원하기 위한 버티포트 내 리소스 최적화 문제 해결에 초점을 맞추고 있다. 이를 위해 본 논문에서는 단일 버티포트 내 리소스의 혼잡도와 이용률을 정량적으로 정의 후 분석하고, 혼합 정수 선형 계획법을 바탕으로 문제를 해결하는 방안을 제안한다. This paper focuses on solving the problem of resource optimization in Vertiport to support the efficient operation of Vertiport, one of the key components of Urban Air Mobility (UAM). To this end, this paper quantitatively defines and analyzes the congestion and utilization rate of resources in a single Vertiport, and proposes a method to solve the problem based on the Mixed Integer Linear Programming method.

복합가공 과정에 의한 대마 뿌리 추출물의 항염증 활성 증진에 관한 비교 연구

유가람,진혜린,김다훈,노중균,김혁,임동우 대한한의학회 2024 대한한의학회지 Vol.45 No.2

Objectives: Cannabis root is a medicinal plant that has been used in traditional medicine around the world. However, in previous studies using simple extracts, the biological activity was not relatively prominent compared to other herbal medicines. The aim of the present study is to confirm the enhancement of anti-inflammatory activity and bioactive compound of Cannabis root extract prepared by combined processing process. Methods: A series of processes including repeated steam and dry, fermentation, hydrothermal extraction and ethanol extraction was applied to Cannabis root. The antioxidant content of cannabis root extracts obtained through a combined processing process was investigated by analyzing the total phenolic, tannin, and flavonoid contents. Anti-inflammatory effects were tested in LPS-treated RAW264.7 cells. The anti-inflammatory mechanism was examined by western blot. Finally, the component profile of Cannabis root extract was analyzed using High Performance Liquid Chromatography (HPLC) and Thin layer chromatography (TLC). Results: The cannabis root extract prepared by complex processing process had higher antioxidant and anti-inflammatory effects than simple extract. Total phenolic and tannin contents were significantly increased, and DPPH free radical inhibition activity was strengthened by combined processing process. Increased NO production and iNOS expression in LPS-treated RAW264.7 cells were decreased in a concentration-dependent manner upon extract treatment by complex processing process. Additionally, the Stigmasterol content of Cannabis root extract was increased through a complex processing process. Conclusions: Further research is needed on the mechanisms and substances that exhibit the anti-inflammatory effects of Cannabis roots extract prepared by complex processing process.

3DEC을 이용한 무등산국립공원 입석대 대표 주상절리의 거동 분석

노정두,김다혜,박혜수,김다훈,한재승,강성승 대한지질공학회 2022 대한지질공학회 학술발표회논문집 Vol.2022 No.2

Importance of Bone Marrow and Soft Tissue Edema to Improve the Diagnostic Accuracy of Lumbosacral MRI for Transverse Process Fractures and Sacral Fractures

권지아,황지영,김민정,권혜영,김다훈 대한영상의학회 2018 대한영상의학회지 Vol.78 No.2

Purpose: To evaluate the magnetic resonance imaging (MRI) findings to improve the diagnostic accuracy for transverse process fractures and sacral fractures. Materials and Methods: The lumbosacral MRI scans of 214 patients (mean age, 60 years; male-to-female ratio, 85:129), who had spine trauma between January and November 2015 were included. Two radiologists evaluated the presence, number, level, and anatomic site of the fractures on MRI with computed tomography as reference standard. Imaging findings were described as cortical disruption, marrow edema, or soft tissue edema on T1-, T2-, and fat-suppressed T2-weighted images. A statistical analysis was performed to compare the diagnostic accuracy of the MRI pulse sequences for the transverse process and sacral fractures. Results: Of 168 fractures, 26 (15.5%) and 13 (4.9%) were in the transverse processes and sacra, respectively. A paravertebral soft tissue edema occurred in the transverse process fractures (80.8%) and presacral soft tissue and marrow edemas occurred in the sacral fractures (46.1%). The sensitivity for the transverse process fractures was 88% on the T2-weighted image. It was 92% on fat- suppressed T2- and T1-weighted images for sacral fractures. Conclusion: Bone marrow and soft tissue edemas on the MRI could potentially improve the diagnostic accuracy of an MRI for fractures in the transverse process and sacrum.

풍력 및 태양광 기초지반 지지구조물용 스파이럴 파일 비트 개발

강성승,노정두,김다혜,박혜수,김다훈,한재승 대한지질공학회 2022 대한지질공학회 학술발표회논문집 Vol.2022 No.2

Eastern Tamang and the NP/DP Macroparameter

Barrie Michael Jonathan Mathew,김다훈 한국생성문법학회 2024 생성문법연구 Vol.34 No.3

This paper deals with a series of papers by Bošković, who proposes a macroparameter to distinguish between DP languages (or article languages) and NP languages (or articleless languages). This NP/DP Macroparameter has garnered significant attention giving rise to much cross-linguistic research on nominals. Nevertheless, macroparameters have not fared well in recent years, and the NP/DP macroparameter also has problems, as we discussed. We evaluate the diagnostics for this macroparameter with data from Eastern Tamang, a dialect of Tamang, a Sino-Tibetan language. We show that the vast majority of the diagnostics fail to indicate the nominal structure of Eastern Tamang, and the few that do give rise to contradictory results. We discuss some problems with the diagnostics and give some tentative suggestions as to how the NP/DP Macroparameter might dissolve into various microparameters, thereby accounting for at least some of the contradictory results uncovered in Eastern Tamang and in other languages.